INTESTINAL CANCERS & DISEASES Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells The authors assessed the significance of prolyl hydroxylase (PHD) enzymes during the metastatic spread of colorectal cancer. PHD expression analysis in 124 colorectal cancer patients revealed that reduced tumoral expression of PHD3 correlated with increased frequency of distant metastases and poor outcome. [Cancer Res] Abstract MACC1 Mediates Acetylcholine-Induced Invasion and Migration by Human Gastric Cancer Cells Researchers demonstrated that acetylcholine acts via M3 muscarinic receptor to promote gastric cancer cell invasion and migration as well as expression of several markers of epithelial-mesenchymal transition. [Oncotarget] Full Article Thymic Stromal Lymphopoietin (TSLP) Inhibits Human Colon Tumor Growth by Promoting Apoptosis of Tumor Cells Investigators found significantly decreased TSLP levels in tumor tissues compared with tumor-surrounding tissues of patients with colon cancer and TSLP levels negatively correlated with the clinical staging score of colon cancer. [Oncotarget] Full Article Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix Researchers investigated the biochemical and physical diversity of extracellular matrix in pair-wised comparisons of healthy, perilesional and colorectal carcinoma specimens. [Sci Rep] Full Article PS341 Inhibits Hepatocellular and Colorectal Cancer Cells through the FOXO3/CTNNB1 Signaling Pathway Scientists demonstrated that PS341 negatively regulated hepatocellular carcinoma and colorectal cancer both in vitro and in vivo, including the inhibition of cell proliferation, epithelial-mesenchymal transition, the expression of stemness-related genes, cell migration and invasiveness. [Sci Rep] Full Article Targeted CFTR Gene Disruption with Zinc-Finger Nucleases in Human Intestinal Epithelial Cells Induces Oxidative Stress and Inflammation Intestinal Caco-2/15 cells with CFTR deletion, displayed innate oxidative and inflammatory features while being more sensitive to pro-oxidant and pro-inflammatory stimuli. [Int J Biochem Cell Biol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH Stem Cell-Specific Endocytic Degradation Defects Lead to Intestinal Dysplasia in Drosophila Researchers showed that UVRAG deficiency in Drosophila intestinal stem cells leads to uncontrolled proliferation and impaired differentiation without preventing autophagy. [Dis Model Mech] Abstract | Full Article Cyclophilin A Is a New M Cell Marker of Bovine Intestinal Epithelium Investigators developed a 2H5-F3 monoclonal antibody through its binding to bovine M cells, and identified the antibody reactive molecule as cyclophilin A. [Cell Tissue Res] Abstract A Novel Culture System for Adult Porcine Intestinal Crypts Jejunal crypts were isolated from murine, human, and juvenile and adult porcine small intestine, suspended in Matrigel, and co-cultured with syngeneic intestinal subepithelial myofibroblasts or cultured without feeder cells in various culture media. [Cell Tissue Res] Abstract |