Intestinal Cell News Volume 2.14 | Apr 22 2016

Relationship Between Increased Fucosylation and Metastatic Potential in Colorectal Cancer
The authors examined the requirement of L-fucose in colorectal cancer (CRC) cells and developed fucose-bound nanoparticles as vehicles for delivery of anticancer drugs specific to CRC. [J Natl Cancer Inst] Abstract

Gastric Lgr5⁺ Stem Cells Are the Cellular Origin of Invasive Intestinal-Type Gastric Cancer in Mice
Researchers deleted Smad4 and PTEN in murine gastric Lgr5⁺ stem cells by the inducible Cre-LoxP system and marked mutant Lgr5⁺ stem cells and their progeny with Cre-reporter Rosa26^tdTomato. [Cell Res] Full Article

Neonatal Colonization of Mice with LGG Promotes Intestinal Development and Decreases Susceptibility to Colitis in Adulthood
Scientists developed an approach to colonize conventionally raised mice with a model probiotic bacterium, Lactobacillus rhamnosus GG (LGG), and to determine the effects of LGG colonization on intestinal development and prevention of colitis in adulthood. [Mucosal Immunol] Abstract

Ablating the Aryl Hydrocarbon Receptor (AhR) in CD11c⁺ Cells Perturbs Intestinal Epithelium Development and Intestinal Immunity
Investigators report that Cre-mediated deletion of AhR in CD11c-expressing cells in C57/BL6 mice is associated with altered intestinal epithelial morphogenesis in vivo. [Sci Rep] Full Article

Curcumin Mediates Oxaliplatin-Acquired Resistance Reversion in Colorectal Cancer Cell Lines through Modulation of CXC-Chemokine/NF-κB Signaling Pathway
The authors showed that NF-κB was hyperactivated in in vitro models of oxaliplatin-acquired resistance but was attenuated by the addition of Curcumin, a non-toxic NF-κB inhibitor. [Sci Rep] Full Article

Posttranscriptional Regulation of Wnt-Coreceptor LRP6 and RNA-Binding Protein HuR by miR-29b in Intestinal Epithelial Cells
Researchers report that mRNAs, encoding Wnt coreceptor LRP6 (LDL receptor-related protein 6) and RNA-binding protein HuR, are novel targets of microRNA-29b (miR-29b) in intestinal epithelial cells and that expression of LRP6 and HuR is tightly regulated by miR-29b at the posttranscriptional level. [Biochem J] Abstract

MicroRNA-204 Modulates Colorectal Cancer Cell Sensitivity in Response to 5-Fluorouracil-Based Treatment by Targeting High Mobility Group Protein A2
Investigators identified high mobility group protein A2 (HMGA2) as a novel direct target of miR-204 and showed that miR-204 expression was decreased while HMGA2 expression was increased in colorectal cancer cell lines. [Biol Open] Full Article

INTESTINAL STEM CELL & ORGANOID RESEARCH

In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment
Colonic organoids derived from cultured, multicellular organoid fragments or single stem cells were exposed in culture to steep linear gradients of two Wnt-signaling ligands, Wnt-3a and R-spondin1. [PLoS One] Full Article

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AbbVie, University of Chicago Collaborate to Advance Cancer Research
The University of Chicago and AbbVie have entered into a five-year collaboration agreement designed to improve the pace of discovery and advance medical research in oncology at both organizations. [The University of Chicago] Press Release

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NEW Clinical Fellow – Cancer Immunotherapy (Fred Hutchinson Cancer Research Center)

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