Intestinal Cell News 2.21 June 10, 2016 | |
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TOP STORYResearchers identified secreted phospholipases A2 (sPLA2s) as stem cell niche factors with context-dependent functions in the digestive tract. They showed that group IIA sPLA2, a known genetic modifier of mouse intestinal tumorigenesis, is expressed by Paneth cells in the small intestine, while group X sPLA2 is expressed by Paneth/goblet-like cells in the colon [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)INTESTINAL CANCERS & DISEASESMyeloid Translocation Genes Differentially Regulate Colorectal Cancer Programs Investigators hypothesized that loss of MTGR1 or MTG16 would modify Apc1638/+-dependent intestinal tumorigenesis. [Oncogene] Abstract MicroRNA-375 Suppresses Human Colorectal Cancer Metastasis by Targeting Frizzled 8 Researchers investigated the impact of microRNA-375 (miR-375) on colorectal cancer (CRC) metastasis. Specifically, miR-375 expression was significantly decreased in human CRC tissues compared with their matched noncancerous tissues, and low levels of miR-375 predicted tumor metastatic potential. [Oncotarget] Full Article Down-Regulated and Commonly Mutated ALPK1 in Lung and Colorectal Cancers Researchers determined whether the expression of ALPK1 has an influence on tumorigenesis and to further scrutinize its gene polymorphism in order to better understand its clinical importance. In lung and colorectal cancer tissues, the ALPK1 RNA level of the normal part was higher than that of the tumor part using the RT-qPCR analysis. [Sci Rep] Full Article KLF4 Deletion Alters Gastric Cell Lineage and Induces MUC2 Expression Krüppel-like factor 4 (KLF4) was deleted by Rosa-Cre in the gastric epithelia cells or by Lgr5-Cre in the antral stem cells in the adult mice. KLF4 deletion resulted in increased proliferating cells and decreased pit mucous cells. The intestinal goblet cell marker, MUC2, which is not expressed in normal gastric tissues, was strongly induced at the base of the KLF4-deleted antral glands. [Cell Death Dis] Full Article Using mammalian reovirus as a model enteric virus, researchers found that the intermediate subviral particles, which are formed in the gut during the natural course of infection by proteolytic digestion of the reovirus virion, trigger reduced innate antiviral immune response in intestinal epithelial cells. [Cell Microbiol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCHThe authors investigated the relationship between aminoacyl-tRNA synthetase interacting multifunctional proteins (AIMPs) and Wnt/β-catenin signaling in a murine model of intestinal homeostasis and tumorigenesis. [Cancer Res] Abstract | Full Article Scientists identified a nuclear long non-coding RNA, termed WiNTRLINC1, as a direct target of TCF4/β-catenin in colorectal cancer cells. WiNTRLINC1 positively regulated the expression of its genomic neighbor ASCL2, a transcription factor that controls intestinal stem cell fate. [Cell Rep] Full Article | Graphical Abstract Heterogeneity in Readouts of Canonical Wnt Pathway Activity within Intestinal Crypts Investigators describe a novel Axin2-CreERT2-tdTomato allele that efficiently marks both WntHigh columnar stem cells and radioresistant reserve intestinal stem cells. [Dev Dyn] Abstract | |
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REVIEWSNoncoding RNA and Colorectal Cancer: Its Epigenetic Role The authors primarily focus on the epigenetic effects modulating noncoding RNA in colorectal cancer. [J Hum Genet] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
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SCIENCE NEWSBristol-Myers Squibb Company announced the first presentation of interim data from the Phase II CheckMate -142 trial evaluating Opdivo alone or in combination with Yervoy in patients with previously treated metastatic colorectal cancer, including those with high microsatellite instability (MSI-H). [Press release from Bristol-Myers Squibb Company (Business Wire) discussing research presented at the 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago] Press Release | |
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INDUSTRY NEWSTheravance Biopharma, Inc. announced positive results from the Company’s Phase I clinical trial of TD-1473, a novel, potent, and orally administered GI-targeted pan-JAK inhibitor. [Theravance Biopharma] Press Release Ironwood Pharmaceuticals, Inc. and Allergan plc announced that the U.S. Food and Drug Administration (FDA) has accepted for review the supplemental New Drug Application for the 72 mcg dose of linaclotide for use in the treatment of adults with chronic idiopathic constipation. [Ironwood Pharmaceuticals, Inc.] Press Release NIH Awards Brown $11.5 Million for Computational Biology Research Brown University will launch a Center for Biomedical Research Excellence in Computational Biology of Human Disease to expand its research using sophisticated computer analyses to understand and fight human diseases. [Brown University] Press Release
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EVENTSNEW Gordon Research Conference – Tissue Niches & Resident Stem Cells in Adult Epithelia Visit our events page to see a complete list of events in the intestinal cell community.
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JOB OPPORTUNITIESNEW Research Technician – Preclinical and Translational Research (Qu Biologics) NEW Postdoctoral Scientists – Regenerative Medicine (Cedars-Sinai) Technical Sales Representative (STEMCELL Technologies Inc.) Program Director and Professor – Immune Mechanisms at Epithelial Surfaces (University of Arizona) Associate Director – Intestinal Microbiota (Institute for Basic Science/POSTECH) Postdoctoral Fellow – Norovirus-Intestinal Microbiota Interactions (University of Florida) PhD Studentship – Gut Bacterial Metabolism (Katholieke Universiteit Leuven) Research Assistant – Autoimmune/Cell Biology (Immunocore Ltd) Faculty Positions – Clinical Immunology (Oklahoma Medical Research Foundation) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Intestinal Cell News Volume 2.21 | Jun 10 2016