Intestinal Cell News Volume 2.22 | Jun 17 2016

TOP STORY

Study Resolves Long-Disputed Theory About Stem Cell Populations

Researchers identified key characteristics that distinguish reserve stem cells from other stem cell populations that had been purported to have similar properties. The work, which employed single-cell gene expression analyses as well as other cutting-edge techniques, demonstrated that, in the intestines, reserve stem cells are a distinct population from so-called “label-retaining cells”. [Press release from the University of Pennsylvania discussing prepublication in Gastroenterology] Press Release | Abstract

(Ranked by impact factor of the journal)

INTESTINAL CANCERS & DISEASES

Reduced CD146 Expression Promotes Tumorigenesis and Cancer Stemness in Colorectal Cancer through Activating Wnt/β-Catenin Signaling

Researchers showed that CD146 knockdown induces stem cell properties in colorectal cancer cells through activating canonical Wnt signaling. [Oncotarget] Full Article

A Novel TP53 Pathway Influences the HGS-Mediated Exosome Formation in Colorectal Cancer

The features of exosomes secreted from HCT116 TP53-wild type, TP53-knockout and constructed TP53-mutant cells were assessed. [Sci Rep] Full Article

Expression of μ-Protocadherin Is Negatively Regulated by the Activation of the β-Catenin Signaling Pathway in Normal and Cancer Colorectal Enterocytes

Researchers showed that expression of mu-protocadherin is negatively regulated by functional activation of the β-catenin signaling pathway. [Cell Death Dis] Full Article

Characterization of V. cholerae T3SS-Dependent Cytotoxicity in Cultured Intestinal Epithelial Cells

Investigators examined the role of bile, sought to identify the mechanism, and evaluated the contributions of Type 3 Secretion System translocated effectors in in vitro cell death. Their results suggest that Caco2-BBE cytotoxicity does not proceed by apoptotic or necrotic mechanisms, but rather displays characteristics consistent with osmotic lysis. [Cell Microbiol] Abstract

Rad51C-ATXN7 Fusion Gene Expression in Colorectal Tumors

Scientists found a fusion gene between DNA repair gene Rad51C and neuro-cerebral ataxia Ataxin-7 gene in colorectal tumors. [Mol Cancer] Full Article

HOTAIRM1 as a Potential Biomarker for Diagnosis of Colorectal Cancer Functions the Role in the Tumor Suppressor

Investigators found that expression of HOTAIRM1 was reduced in colorectal cancer (CRC) tissues compared with matched normal tissues, and plasma HOTAIRM1 levels in CRC patients were less than in controls. [J Cell Mol Med] Abstract

Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine

Researchers analyzed the intestinal phenotype of GSK3 knockin mice in which N-terminal serines 21/9 of glycogen synthase kinase 3α/β have been mutated to non-phosphorylatable alanine residues. [PLoS One] Full Article

The Role of Probiotics in Lipopolysaccharide-Induced Autophagy in Intestinal Epithelial Cells

The authors assessed the effect of probiotics on lipopolysaccharide-induced physical barrier dysfunction and the underlying mechanism of probiotic action in intestinal epithelial cells with a focus on autophagy. [Cell Physiol Biochem] Abstract

hPSC-Derived Lung and Intestinal Organoids as Models of Human Fetal Tissue

The authors discuss current methods for differentiating lung and intestinal tissue from human pluripotent stem cell (hPSCs) into individual 3-dimensional units called organoids. [Dev Biol] Full Article

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Cellceutix Starts Phase II Trial of Brilacidin as a Novel Therapy for Ulcerative Proctitis

Cellceutix Corporation announced that patients have been screened and the administration of Brilacidin to patients is expected to begin in the Phase II Proof of Concept trial of Brilacidin for the treatment of ulcerative proctitis. [Cellceutix Corporation] Press Release

Health Canada Approves INFLECTRA^® (Biosimilar Infliximab) for Three Additional Indications: Crohn’s Disease, Fistulising Crohn’s Disease and Ulcerative Colitis

Hospira announced that INFLECTRA^® has been approved by Health Canada for three additional indications, Crohn’s disease, fistulizing Crohn’s disease and ulcerative colitis. [Pfizer Canada Inc.] Press Release

NEW Nordic Life Science Days 2016
September 14-15, 2016
Stockholm, Sweden

Visit our events page to see a complete list of events in the intestinal cell community.

NEW Postdoctoral Researcher – Cancer Stem Cells (Institut d’Investigació Biomèdica de Girona)

NEW PhD Student – Intestinal Epithelial Cell Death and Barrier Function (University of East Anglia)

NEW Postdoctoral Fellow – Intestinal Microbiota (University of Florida)

NEW Faculty Position – Phage Biology and Microbiome Research (McMaster University)

Technical Sales Representative (STEMCELL Technologies Inc.)

Research Technician – Preclinical and Translational Research (Qu Biologics)

Postdoctoral Scientists – Regenerative Medicine (Cedars-Sinai)

Postdoctoral/Research Associate – Epigenetics of Immunology and Mucosal Immunity (University of Texas Health Science Center)

Program Director and Professor – Immune Mechanisms at Epithelial Surfaces (University of Arizona)

Postdoctoral Fellow – Norovirus-Intestinal Microbiota Interactions (University of Florida)

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