Intestinal Cell News 2.24 July 8, 2016 | |
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TOP STORYStem Cell Points the Way to Individualized Treatment of Cystic Fibrosis Researchers have now demonstrated in a proof of principle study among a small number of patients that the efficacy of a medicine can be demonstrated for a particular patient using that patient’s intestinal stem cells. This enables the physician to select the medicine or combination of medicines that is most likely to be efficacious in that particular patient. [Press release from UMC Utrecht discussing online prepublication in Science Translational Medicine] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)INTESTINAL CANCERS & DISEASESHemidesmosome Integrity Protects the Colon against Colitis and Colorectal Cancer Researchers developed new mouse models inducing intestinal epithelial cells-specific ablation of α6 integrin either during development or in adults. [Gut] Full Article The authors demonstrated that SARI deficiency facilitates AOM/DSS-induced colonic tumorigenesis in mice. They showed that SARI is a novel inhibitor of colon tumor growth and angiogenesis in mice. [Nat Commun] Full Article To elucidate mechanisms by which p40 regulates mucosal immunity to prevent inflammation, scientists aimed to determine the effects and mechanisms of p40 on regulation of a proliferation-inducing ligand (APRIL) expression in intestinal epithelial cells for promoting immunoglobulin A (IgA) production. [Mucosal Immunol] Abstract Primary intestinal epithelial cells were isolated from small intestine of C57BL/6J mice fed a low-fat diet or high-fat diet for 12 weeks. [Sci Rep] Full Article Investigators aimed to investigate the expression and the potential mechanisms of miR-203 in colorectal cancer. [Sci Rep] Full Article Development of an ultra-sensitive laser-capture microdissection/RNA-seq approach for studying the epithelial and stromal compartments of aberrant crypt foci is described. [Mol Cancer Res] Abstract Investigation of JAKs-STAT 3 in Lipopolysaccharide-Induced Intestinal Epithelial Cells To elucidate the different roles of Janus-activated kinases (JAKs) in the activation of signal transducer and activator of transcription 3 (STAT3), the lipopolysaccharide-induced primary intestinal epithelial cell acute inflammatory model was established. [Clin Exp Immunol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCHGastric Lgr5+ Stem Cells Are the Cellular Origin of Invasive Intestinal-Type Gastric Cancer in Mice Scientists deleted Smad4 and PTEN in murine gastric Lgr5+ stem cells by the inducible Cre-LoxP system and marked mutant Lgr5+ stem cells and their progeny with Cre-reporter Rosa26tdTomato. [Cell Res] Abstract The authors studied normal fission in tissue in three dimensions using high-resolution imaging and used intestinal organoids to identify underlying mechanisms. [PLoS Biol] Full Article Functional Characterization of Cholera Toxin Inhibitors Using Human Intestinal Organoids Investigators used intestinal organoids to quantitatively study the potency of multivalent cholera toxin inhibitors. [J Med Chem] Abstract | |
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REVIEWSSporadic Colorectal Cancer: Microbial Contributors to Disease Prevention, Development and Therapy The authors discuss recent advances in the understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoral immune response. [Br J Cancer] Full Article Visit our reviews page to see a complete list of reviews in the intestinal cell research field.
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SCIENCE NEWSMerck will present data from the pivotal Phase III TAILOR study in patients from China, the first prospective trial to evaluate an anti-EGFR antibody in the first-line therapy of patients with RAS wild-type metastatic colorectal cancer. [Press release from Merck (PR Newswire Association LLC.) discussing research presented at ESMO 18th World Congress on Gastrointestinal Cancer, Barcelona] Press Release | |
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INDUSTRY NEWSTakeda Pharmaceutical Company Limited and TiGenix NV announced that the companies have entered into an exclusive ex-U.S. license, development and commercialization agreement for Cx601, a suspension of allogeneic adipose-derived stem cells injected intra-lesionally for the treatment of complex perianal fistulas in patients with Crohn’s disease. [Takeda Pharmaceutical Company Limited] Press Release ColonaryConcepts, LLC announced positive topline results from a randomized, colonoscopist-blinded Phase II clinical study of the company’s novel investigational colonoscopy prep kit. [ColonaryConcepts, LLC] Press Release
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POLICY NEWSU.K. Research Charity Will Self-Publish Results from Its Grantees Starting sometime this fall, the Wellcome Trust will launch its own open-access online journal. Publication will be limited to the thousands of scientists worldwide working on research funded by a Wellcome grant, and it will be free not only for readers, but authors—the charity is covering the costs charged by the company that will provide the journal’s software and online platform. [ScienceInsider] Editorial Canada’s Health Funder Agrees to Meet with Researchers Outraged by Peer-Review Changes Canadian Institute of Health Research (CIHR) President Alain Beaudet said the agency will heed Jane Philpott’s request to “convene a working meeting in the very near future with key representatives of the research community, including those who have raised this issue publicly, to find common ground and move forward with solutions that address the issues raised with regard to the quality and integrity of CIHR’s peer review system. [ScienceInsider] Editorial
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EVENTSNEW AACR’s Colorectal Cancer: From Initiation to Outcomes Visit our events page to see a complete list of events in the intestinal cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Training Fellow – Intestinal Stem Cell (Francis Crick Institute) NEW Postdoctoral Researcher – Colon Cancer (German Cancer Research Center) Technical Sales Representative (STEMCELL Technologies Inc.) Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center) PhD Student – Intestinal Epithelial Cell Death and Barrier Function (University of East Anglia) Research Technician – Preclinical and Translational Research (Qu Biologics) Postdoctoral Scientists – Regenerative Medicine (Cedars-Sinai) Program Director and Professor – Immune Mechanisms at Epithelial Surfaces (University of Arizona) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Intestinal Cell News Volume 2.24 | Jul 8 2016