Intestinal Cell News Volume 2.26 | Jul 22 2016

TOP STORY

Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules

Researchers describe derivation of human induced endodermal progenitor cells from gastrointestinal epithelial cells using a cocktail of defined small molecules along with support from tissue-specific mesenchymal feeders. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

INTESTINAL CANCERS & DISEASES

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

Scientists showed a critical role for autophagy in the intestine, a major metabolic tissue, to ensure lifespan extension of dietary-restricted eat-2 mutants. [PLoS Genet] Full Article

SOX9 Is an Atypical Intestinal Tumor Suppressor Controlling the Oncogenic Wnt/ß-Catenin Signaling

The authors report a heterozygous L142P inactivating mutation of SOX9 in the DLD-1 colorectal cancer cell line and they demonstrated that the conditional expression of a wild type SOX9 in this cell line inhibits cell growth, clonal capacity and colonosphere formation while decreasing both the activity of the oncogenic Wnt/ß-catenin signaling pathway and the expression of the c-myc oncogene. [Oncotarget] Full Article

Accumulation of Arachidonic Acid-Containing Phosphatidylinositol at the Outer Edge of Colorectal Cancer

Researchers aimed to seek out the cancer cell-autonomous acquisition of cancer outer edge-characterizing lipids in colorectal cancer by analyzing phospholipids in cancer tissue-originated spheroids derived from colorectal cancer patients with matrix-assisted laser desorption/ionization-imaging mass spectrometry. [Sci Rep] Full Article

Induction of Cell Differentiation Activates Transcription of the Sarco/Endoplasmic Reticulum Calcium-ATPase 3 Gene (ATP2A3) in Gastric and Colon Cancer Cells

Investigators demonstrated that Sarco/Endoplasmic Reticulum Ca²⁺-ATPase (SERCA) 3 mRNA is upregulated up to 45-fold in two epithelial cancer cell lines, KATO-III and Caco-2, induced to differentiate with histone deacetylase inhibitors and by cell confluence, respectively. [Mol Carcinog] Abstract

Redox Control of Cas Phosphorylation Requires Abl Kinase in Regulation of Intestinal Epithelial Cell Spreading and Migration

Scientists evaluated the role of Abl regulation of Cas at the level of cell spreading and migration during wound closure. As a model, they used intestinal epithelial cells exposed to H₂O₂ or scratch-wounded to assess the Abl-Cas signaling pathway. [Am J Physiol Gastrointest Liver Physiol] Abstract

Clitocine Potentiates TRAIL-Mediated Apoptosis in Human Colon Cancer Cells by Promoting Mcl-1 Degradation

Scientists found that pretreatment with clitocine dramatically enhances TRAIL lethality in its resistant human colon cancer cells by inducing apoptosis. [Apoptosis] Abstract

The ANXA1 Released from Intestinal Epithelial Cells Alleviate DSS-Induced Colitis by Improving NKG2A Expression of Natural Killer Cells

The expression of ANXA1 in intestinal epithelial cells from DSS treated mice was increased, and more natural killer cells were recruited to intestinal mucosa. [Biochem Biophys Res Commun] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells

Scientists applied human induced pluripotent stem cell-derived enterocytes in pharmacokinetic studies by investigating the characteristics of drug transport into enterocyte-like cells. [Drug Metab Dispos] Abstract | Full Article

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

The authors review the current understanding of complex interactions between the intestinal epithelium and immune cells, with a focus on pathologic mucosal inflammation and mechanisms of epithelial repair. [Gastroenterology] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Seres Therapeutics and Emulate Announce Collaboration to Support the Development of Novel Microbiome Therapeutics for Inflammatory Bowel Disease and other Serious Conditions

Seres Therapeutics, Inc. and Emulate, Inc. announced a new collaboration. Under the terms of the agreement, Seres and Emulate will work to further advance Emulate’s Intestine-Chip platform, a micro-engineered, living-tissue-based system that models the human intestine. [Seres Therapeutics] Press Release

Ionis Pharmaceuticals Licenses First Oral Antisense Drug Acting Locally in the GI Tract to Janssen

Ionis Pharmaceuticals, Inc. announced that it has earned $10 million from Janssen Biotech, Inc. upon licensing IONIS-JBI1-2.5Rx, an orally delivered antisense drug designed to locally inhibit an undisclosed target in the gastrointestinal (GI) tract for the treatment of a GI autoimmune disease. [Ionis Pharmaceuticals] Press Release

Regeneron Announces 2016 Winners of the Regeneron Prize for Creative Innovation

Regeneron Pharmaceuticals, Inc. announced the winners of the fourth annual Regeneron Prize for Creative Innovation, an award designed to acknowledge, reward and foster talented early-career biomedical scientists. This year, Regeneron awarded $155,000 in prize money to 10 awardees and two institutions. [Pharmaceuticals, Inc.] Press Release

Dutch Agency Launches First Grants Program Dedicated to Replication

The Netherlands has launched what researchers say is the world’s first national fund dedicated to replication studies: a pot of €3 million over the next 3 years for Dutch scientists to test whether they can reproduce important research results in social and medical sciences. [Nature News] Editorial

First Greek Science Agency Is Rare Source of Joy for Beleaguered Researchers

A massive loan from the European Union’s investment bank gives Greek researchers their first ray of hope since the debt crisis hit six years ago: a government-backed plan to create a Greek research agency. [Nature News] Editorial

Chinese Scientists to Pioneer First Human CRISPR Trial

Chinese scientists are on the verge of being first in the world to inject people with cells modified using the CRISPR–Cas9 gene-editing technique. A team led by Lu You, an oncologist at Sichuan University’s West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month. [Nature News] Editorial

NEW 4^th International Oncology Conference
September 29-30, 2016
Abu Dhabi, United Arab Emirates

Visit our events page to see a complete list of events in the intestinal cell community.

NEW PhD Position – Mesenchymal Niche Signaling in Colon Cancer (Georg-Speyer-Haus)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Position – Mucosal Immunology (KU Leuven)

Postdoctoral Training Fellow – Intestinal Stem Cell (Francis Crick Institute)

Postdoctoral Researcher – Colon Cancer (German Cancer Research Center)

Postdoctoral Position – Cell Biology of Listeria transcytosis Across the Intestinal Epithelium (Institut Pasteur Parius)

Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center)

PhD Student – Intestinal Epithelial Cell Death and Barrier Function (University of East Anglia)

Research Technician – Preclinical and Translational Research (Qu Biologics)

Postdoctoral Scientists – Regenerative Medicine (Cedars-Sinai)

Program Director and Professor – Immune Mechanisms at Epithelial Surfaces (University of Arizona)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Intestinal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.