Intestinal Cell News Volume 2.28 | Aug 5 2016

TOP STORY

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon

The 5-hydroxytryptamine receptor 4 (5-HT4R) is expressed in the colonic epithelium but little is known about its functions there. Scientists examined whether activation of colonic epithelial 5-HT4R protects colons of mice from inflammation. [Gastroenterology] Abstract

(Ranked by impact factor of the journal)

INTESTINAL CANCERS & DISEASES

Stromal Hedgehog Signaling Is Downregulated in Colon Cancer and Its Restoration Restrains Tumor Growth

Scientists used Hedgehog (Hh) reporter mice to show that downstream Hh activity is unexpectedly diminished in a mouse model of colitis-associated colon cancer, and that downstream Hh signaling is restricted to the stroma. [Nat Commun] Full Article

ADAM17 Is a Tumor Promoter and Therapeutic Target in Western Diet-Associated Colon Cancer

Researchers investigated CXCR4-ADAM17 crosstalk and examined the role of ADAM17 in tumorigenesis. [Clin Cancer Res] Abstract

miR-449a Inhibits Colorectal Cancer Progression by Targeting SATB2

Scientists investigated the expression and functional significance of miR-449a and SATB2 and the mechanisms of their dysregulation in human colorectal cancer cells. [Oncotarget] Full Article

Edible Ginger-Derived Nano-Lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

The authors describe a nanovector made from ginger-derived lipids that can serve as a delivery platform for the therapeutic agent doxorubicin to treat colon cancer. [Mol Ther] Abstract

Ceramide Mediates FasL-Induced Caspase 8 Activation in Colon Carcinoma Cells to Enhance FasL-Induced Cytotoxicity by Tumor-Specific Cytotoxic T Lymphocytes

Investigators aimed at testing the hypothesis that novel ceramide analogs effectively modulate Fas function to sensitize colon carcinoma cells to Fas ligand (FasL)-induced apoptosis. [Sci Rep] Full Article

Total Glucosides of Paeony Promote Intestinal Motility in Slow Transit Constipation Rats through Amelioration of Interstitial Cells of Cajal

Using an atropine-diphenoxylate-induced slow transit constipation (STC) model, this study explored the effects of the total glucosides of paeony in the treatment of STC and the possible mechanisms. [PLoS One] Full Article

Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage

Investigators elucidate the pathway that mediates internalization of outer membrane vesicles from the probiotic E.coli Nissle 1917 and the commensal ECOR12 strains in several human intestinal epithelial cell lines. [PLoS One] Full Article

Cationic MicroRNA-Delivering Nanocarriers for Efficient Treatment of Colon Carcnoma in Xenograft Model

Researchers studied a PLGA/polyethylenimine-mediated microRNA vector delivery system, validating the method employing colon cancer xenograf model with miR-145 vector encoding for the expression of miR-145 [Gene Ther] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5⁺ Intestinal Stem Cells

Scientists hypothesized that the normal lymphocyte balance within the lamina propria of the intestine can be achieved via administration of all-trans retinoic acid which restores mucosal integrity by preventing the loss of intestinal stem cells. [Shock] Abstract

The Culture of Gut Explants: A Model to Study the Mucosal Response

The authors provide a review of some of the possible uses of organ intestinal mucosa culture. [J Immunol Methods] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Check-Cap Awarded $1.25 Million Grant for 2016 From Israel’s Office of the Chief Scientist

Check-Cap Ltd. announced that Israel’s Office of the Chief Scientist has awarded the Company a grant of NIS 4.8 million (approximately equivalent to $1.25 million based on the current exchange rate) for 2016. [Check-Cap Ltd.] Press Release

Synthetic Biologics Announces Completion of End of Phase II Meeting with FDA for SYN-010, Intended for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)

Synthetic Biologics, Inc. announced the completion of an End of Phase II meeting with the U.S. Food and Drug Administration (FDA) for SYN-010, designed to treat an underlying cause of the symptoms commonly associated with IBS-C. [Synthetic Biologics, Inc.] Press Release

Damon Runyon Cancer Research Foundation Grants Prestigious Fellowship Awards to 17 Top Young Scientists

The Damon Runyon Cancer Research Foundation named 17 new Damon Runyon Fellows at its spring Fellowship Award Committee review. [Damon Runyon Cancer Research Foundation] Press Release

Russian Scientists Bracing for Massive Job Losses

Russia’s scientific community is reeling from news that the government plans to fire about 10,000 researchers over the next three years. [ScienceInsider] Editorial

Scientists Seek Influence on ‘Brexit Ministry’

Worried at the prospect of losing access to EU funding and collaborations, scientific societies have fired off numerous letters asking the government to keep their country in the EU’s research system, and warning of damage already caused by Brexit. [Nature News] Editorial

Antibiotics Funding Splurge Gets Mixed Reception

Antibiotics researchers are set to receive hundreds of millions of dollars from a new funding stream — but not everyone thinks the cash is being directed to the right place. [Nature News] Editorial

Young Blood Antiaging Trial Raises Questions

A startup company has launched the first clinical trial in the United States to test the antiaging benefits of young blood in relatively healthy people. But there’s a big caveat: It’s a pay-to-participate trial, a type that has raised ethical concerns before, most recently in the stem cell field. [ScienceInsider] Editorial

NEW Organoids: Modeling Organ Development and Disease in 3D Culture
October 12-15, 2016
Heidelberg, Germany

Visit our events page to see a complete list of events in the intestinal cell community.

NEW Senior Scientist – Human Microbiome (Nestle Institute of Health Sciences)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Research Scientist – Chromatin Dynamics in Intestinal Innate Immunity Gene Expression (The Babraham Institute)

Postdoctoral Position – Mucosal Immunology (KU Leuven)

Postdoctoral Training Fellow – Intestinal Stem Cell (Francis Crick Institute)

Postdoctoral Researcher – Colon Cancer (German Cancer Research Center)

Postdoctoral Position – Cell Biology of Listeria transcytosis Across the Intestinal Epithelium (Institut Pasteur Parius)

Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center)

PhD Student – Intestinal Epithelial Cell Death and Barrier Function (University of East Anglia)

Research Technician – Preclinical and Translational Research (Qu Biologics)

Postdoctoral Scientists – Regenerative Medicine (Cedars-Sinai)

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