Intestinal Cell News Volume 2.40 | Oct 28 2016

TOP STORY

Selective Targeting of Mutant Adenomatous Polyposis Coli (APC) in Colorectal Cancer

The authors identified a drug called TASIN-1 (truncated APC selective inhibitor–1), which specifically targets cells with APC truncations, the most common APC mutation seen in colorectal cancer. [Sci Transl Med] Abstract | Press Release

(Ranked by impact factor of the journal)

INTESTINAL CANCERS & DISEASES

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria

Researchers assessed the role of solute carrier family 7 member 2 in murine infection with Citrobacter rodentium, an attaching and effacing enteric pathogen that causes colitis. [PLoS Pathog] Full Article

Serum Exosomal miR-4772-3p Is a Predictor of Tumor Recurrence in Stage II and III Colon Cancer

Scientists evaluated the prognostic or predictive value of serum exosomal microRNAs for tumor recurrence and response to adjuvant therapy in stage II and stage III colon cancer. [Oncotarget] Full Article

The Deubiquitinase USP54 Is Overexpressed in Colorectal Cancer Stem Cells and Promotes Intestinal Tumorigenesis

The authors show that USP54 is overexpressed in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes tumorigenesis. [Oncotarget] Full Article

Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1.

The autotaxin (ATX)- lysophosphatidic acid axis plays an important role in various physiological and pathological processes, especially in inflammation and cancer development. Although the transcriptional regulation of ATX has been widely studied, the post-transcriptional regulation of ATX is largely unknown. In this study, the authors identified conserved adenylate-uridylate-rich elements in the ATX mRNA 3′ untranslated region. [J Biol Chem] Abstract | Full Article

A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction

Investigators tested the hypothesis that PD-L1 expressed on intestinal epithelial cells has a role in sepsis-induced intestinal barrier dysfunction. [Mol Med] Full Article

Curcumin Analog EF24 Induces Apoptosis via ROS-Dependent Mitochondrial Dysfunction in Human Colorectal Cancer Cells.

The anti-tumor effects of EF24, a novel analog of the natural compound curcumin, were evaluated in colorectal cancer cells. [Cancer Chemother Pharmacol] Abstract

Infliximab Therapy Reverses the Increase of Allograft Inflammatory Factor-1 in Serum and Colonic Mucosa of Rats with Inflammatory Bowel Disease

Investigators studied the molecular basis of infliximab effect on colon mucosa in a colitis model and identified new biomarkers of mucosal healing. [Biomarkers] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Mitochondrial Function Controls Intestinal Epithelial Stemness and Proliferation

Scientists report that mitochondrial function plays a critical role in maintaining intestinal stemness and homeostasis. [Nat Commun] Full Article | Press release

Both the Anti- and Pro-Apoptotic Functions of Villin Regulate Cell Turnover and Intestinal Homeostasis

The authors validate the physiological role of villin in apoptosis and cell extrusion from the gastrointestinal epithelium. [Sci Rep] Full Article

The Genetic Background of Inflammatory Bowel Disease: From Correlation to Causality

The authors present the progress that has been made in inflammatory bowel disease (IBD) genetic research and stress the importance of studying causality to increase our understanding of the pathogenesis of IBD. [J Pathol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

$30 Million Gift to UCLA Health Sciences Will Accelerate Research, Education and Patient Care

Tamar and Vatche Manoukian have made a gift to the Division of Digestive Diseases at the David Geffen School of Medicine at UCLA that will provide unrestricted funds to accelerate research, innovative clinical care and educational priorities. [UCLA] Press Release

Boston Biomedical Initiates CanStem303C: A Global Phase III Study Investigating Cancer Stemness Inhibitor Napabucasin in Patients With Pretreated Advanced Colorectal Cancer

Boston Biomedical announced dosing of the first patient in CanStem303C, a new global Phase III study investigating napabucasin in combination with standard of care in patients with previously treated metastatic colorectal carcinoma. [Boston Biomedical] Press Release

Review Finds Misconduct in Events Surrounding WHO Fetal Growth Study

For the first time in its 68-year history, the World Health Organization (WHO) has concluded that researchers are guilty of research misconduct. An independent review commissioned by WHO has found that “research ethics misconduct occurred” in a multimillion-dollar global study on fetal growth led by researchers at the University of Oxford in the United Kingdom. [ScienceInsider] Editorial

Two Major California Research Institutes Will Merge

One of the biggest nonprofit biomedical research outfits in the world is getting a new translational medicine research arm, aimed at speeding the conversion of basic research insights into novel medicines. Officials at the Scripps Research Institute announced that it will merge with the California Institute for Biomedical Research, which was launched in 2012 as a nonprofit version of a drug development company. [ScienceInsider] Editorial

To Save Money, NSF Requires University Cost-Sharing for Rotators

The National Science Foundation (NSF) has decided that universities should pay 10% of the salaries of faculty members working temporarily at the agency. NSF hopes the new policy will demonstrate its commitment to saving taxpayer dollars without alienating the academic community that it relies upon to stay on the cutting edge of basic science. [ScienceInsider] Editorial

Scientific Challenges Loom for Canada’s Popular Prime Minister

Many in Canada’s science community say they are reserving judgement, waiting to see whether Trudeau can sustain his string of victories as he tackles some of country’s thorniest science-policy issues. [Nature News] Editorial

NEW 29^th Lorne Cancer Conference
February 9-11, 2017
Lorne, Australia

Visit our events page to see a complete list of events in the community.

NEW Portfolio Manager – Material and Recipe Manager (Nestle Institute of Health Sciences)

Postdoctoral Fellow – Molecular Infection Biology (Umeå University)

Postdoctoral Research Fellow – Intestinal Stem Cell Repair Mechanisms after Injury and Inflammation (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Intestinal Tissue Engineering (Francis Crick Institute)

Postdoctoral Fellow – Mucosal immunology / Neuro-immune interaction (KU Leuven)

Director – Basic and Translational Research (University of Maryland School of Medicine)

PhD Scholarship – Intestine Modeling for Drug Delivery Studies (Technical University of Denmark)

Chair in Medical Biology – Head of the Department of Biology (Masaryk University)

Postdoctoral Research Fellow – Cancer Epidemiology (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow or PhD Student – Gastrointestinal Cancers (Goethe University Frankfurt)

Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center)

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