Intestinal Cell News 3.20 June 2, 2017 | |
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TOP STORYResearchers aimed to target metastasis associated in colon cancer 1 (MACC1) expression using a luciferase reporter-based high-throughput screening with the ChemBioNet library of more than 30,000 compounds. The small molecules lovastatin and rottlerin emerged as the most potent MACC1 transcriptional inhibitors. They inhibited MACC1 promoter activity and expression, resulting in reduced cell motility. [PLoS Biol] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)INTESTINAL CANCERS & DISEASESAutocrine WNT2 Signaling in Fibroblasts Promotes Colorectal Cancer Progression Scientists showed that WNT2 is one of the most significantly induced genes in colorectal cancer stroma as compared to normal stroma. They identified cancer-associated fibroblasts (CAFs) as the main source of WNT2. CAF-derived WNT2 activated canonical signaling in adenomatous polyposis coli/β-catenin wild-type colon cancer cells in a paracrine fashion, whereas no hyperactivation was detectable in cell lines harboring mutations in the adenomatous polyposis coli/β-catenin pathway. [Oncogene] Abstract Nitrogen Isotopes Provide Clues to Amino Acid Metabolism in Human Colorectal Cancer Cells Scientists used the natural abundances of nitrogen isotopes of individual amino acids from human colorectal cancer cell lines to investigate isotope discrimination among amino acids. Significant effects were noticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cells. [Sci Rep] Full Article The authors found that DICER was downregulated in tumor samples of colorectal cancer patients at both mRNA and protein levels. Intestinal epithelial cell (IEC)-specific deletion of Dicer mice got more tumors after azoxymethane and dextran sulfate sodium (DSS) administration. IEC-specific deletion of Dicer led to severe chronic inflammation and epithelium layer remodeling in mice with or without DSS administration. [Oncotarget] Full Article Scientists aimed to figure out which glycolysis enzyme participates in the development of colorectal cancer and its possible mechanisms. CRISPR-Cas9 method was adopted to create knock out colon cancer cell lines of aldolase B (ALDOB). The effect of ALDOB on cell proliferation and metastasis was examined in vitro using colony formation assay as well as transwell migration and invasion assay, respectively. [Cell Physiol Biochem] Full Article Investigators examined the various cellular effects of miR-186-5p in the carcinogenesis of colorectal cancer. Significant high expression of miR-186-5p was noted in cancer tissues and cell lines when compared to control tissues and cells. The majority of the patients with colorectal cancer had shown overexpression of miR-186-5p. [Exp Cell Res] Abstract The authors investigated the effect of miR-101 on proliferation, migration, invasion, and chemotherapy sensitivity in colon cancer cell lines HT-29 and RKO. The expression of miR-101 decreased in colon cancer tissues compared with adjacent non-tumor tissues. The upregulated expression of miR-101 suppressed cell proliferation and inhibited cell migration and invasion in HT-29 and RKO colon cancer cell lines. [Oncol Rep] Full Article INTESTINAL STEM CELL & ORGANOID RESEARCHIn the Drosophila adult gut, high levels of reactive oxygen species has been detected with different types of tissue damage, and oxidative stress has been shown to be both necessary and sufficient to trigger intestinal stem cell (ISC) proliferation. In a screen for genes required for ISC proliferation in response to oxidative stress, investigators identified two regulators of cytosolic Ca2+ levels, transient receptor potential A1 (TRPA1) and ryanodine receptor (RyR). [eLife] Full Article Establishment of a Refined Culture Method for Rat Colon Organoids Researchers established an advanced method for efficient rat colonic stem cell culture. Using various tissue homogenates, they investigated the colonic organoid forming capacity under the TMDU protocol immediately adjacent to Ootani’s 3D culture assembly in the same culture dish. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSScientists focus on recent approaches for colon-specific drug delivery (CDDS) and unveil the emerging possibilities and advances in the treatment of colon cancer with CDDS. [Drug Discov Today] Abstract Role of TGF-β in Metastatic Colon Cancer: It Is Finally Time for Targeted Therapy The authors analyze the molecular mechanisms leading to transforming growth factor-beta (TGF-β) dysregulation in tumor and stroma cells and the modification of the microenvironment that fosters colorectal cancer metastasis. [Cell Tissue Res] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSArray BioPharma and Bristol-Myers Squibb Announce Strategic Collaboration Array BioPharma and Bristol-Myers Squibb Company announced that the companies have entered into a clinical research collaboration to investigate the safety, tolerability and efficacy of Array’s investigational MEK inhibitor, binimetinib in combination with Bristol-Myers Squibb’s Opdivo and Opdivo + Yervoy regimen as a potential treatment for metastatic colorectal cancer in patients with microsatellite stable tumors. [Bristol-Myers Squibb Company] Press Release Latest Grant Awards Bring More than $6 Million to Roswell Park Research Projects Researchers have garnered $6.4 million in new grant funding to support important investigations, including an award of more than $2 million from the National Cancer Institute to Yuesheng Zhang, MD, PhD, Professor of Oncology in the Department of Pharmacology & Therapeutics, for his research to improve colorectal cancer treatment. Dr. Zhang’s five-year investigation aims to evaluate the ability of a recombinant human protein to overcome resistance to the cancer drug cetuximab, a common problem in the treatment of colorectal cancer. [Roswell Park Cancer Institute] Press Release Janssen Biotech, Inc. announced that it has entered into a worldwide exclusive license and collaboration agreement with Protagonist Therapeutics, Inc. to develop, manufacture and commercialize PTG-200, a first-in-class, oral interleukin-23 receptor antagonist drug candidate in development for the treatment of Crohn’s disease and ulcerative colitis. [Janssen Biotech, Inc.] Press Release | |
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POLICY NEWSTrials of Embryonic Stem Cells to Launch in China The first clinical trial in China using human embryonic stem (ES) cells, and the first one worldwide aimed at treating Parkinson’s disease using ES cells from fertilized embryos, will begin in the next few months. In a second trial starting around the same time, a different team in Zhengzhou will use ES cells to target vision loss caused by age-related macular degeneration. [Nature News] Editorial Web of Science Owner Buys up Booming Peer-Review Platform The owner of the vast science-citation database Web of Science — Clarivate Analytics — is buying up a firm that has gathered hundreds of thousands of peer-review records, in a deal that could lead to new ways of organizing scientific peer review and preventing peer-review fraud. [Nature News] Editorial Pay-to-View Blacklist of Predatory Journals Set to Launch Five months after a widely read blog listing possible ‘predatory’ scholarly journals and publishers was shut down, another index of untrustworthy titles is appearing — although this version will be available only to paying subscribers. [Nature News] Editorial NIH Finds Using Anonymous Proposals to Test for Bias Is Harder than It Looks An effort to test whether reviewers are biased against blacks applying for grants from the National Institutes of Health (NIH) is proving to be much harder to carry out than expected. [ScienceInsider] Editorial
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EVENTSNEW Gordon Research Conferences: Biomaterials & Tissue Engineering NEW Molecular, Physiological, and Therapeutic Studies of Intestinal Lipid Transport and Metabolism Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Colorectal Cancer (NUI Galway) PhD Studentship – Human Intestinal Epithelial Cell Biology (University of Cambridge) Postdoctoral Fellow – Medical Biochemistry and Mucin Biology (University of Gothenburg) Chief – Division of Gastroenterology and Hepatology (University of Nebraska Medical Center) Postdoctoral Research Fellow – Inflammatory Bowel Disease (Children’s Hospital Los Angeles) Postdoctoral Research Fellow – Cancer Epidemiology (Fred Hutchinson Cancer Research Center) PhD Position – Colorectal Cancer (German Cancer Research Center/DKFZ) Postdoctoral Fellow – Nanomedicine (Johns Hopkins University) Postdoctoral and PhD Positions – Bio-Nano Science (University of South Australia) Postdoctoral Fellow Position – Cancer Biology (Emory University) Assistant or Associate Member – Stem Cell/Gene Therapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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