Intestinal Cell News 3.40 October 20, 2017 | |
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TOP STORYDDB2 Is a Novel Regulator of Wnt-Signaling in Colon Cancer Scientists report that the damage-specific DNA-binding protein DDB2 is critical for β-catenin-mediated activation of RNF43, which restricts Wnt signaling by removing Wnt receptors from the cell surface. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Knockdown of mutated in colorectal cancer (MCC) in HCT116 colon cancer cells caused a reduction in E-cadherin protein level, which is a hallmark of epithelial–mesenchymal transition in cancer, and consequently diminished the E-cadherin/β-catenin complex. [Oncogene] Abstract Using SPR analysis and enzyme activity assay on recombinant TrxR1 protein, scientists showed that costunolide directly binds and inhibits the activity of TrxR1, which caused enhanced generation of ROS and led to ROS-dependent endoplasmic reticulum stress and cell apoptosis in colon cancer cells. [Cancer Lett] Abstract Interaction of Cruciferin-Based Nanoparticles with Caco-2 Cells and Caco-2/HT29-MTX Co-Cultures Researchers showed that the uptake of negatively-charged cruciferin (Cru)/calcium particles to be ~3 times higher than positively-charged Cru/chitosan ones by Caco-2 cells. Presence of mucus secreted by HT29 cells in their co-culture with Caco-2 had negligible influence on the uptake and transport of both particles. [Acta Biomater] Full Article Treatment with AU14022 increased p53 protein expression, p53 Ser15 phosphorylation, p53-mediated expression of downstream target genes, and apoptosis in p53-wild-type HCT116 human colon cancer cells, but not in p53-knockout HCT116 cells. [J Cell Physiol] Abstract The farnesoid X receptor (FXR) plays an important role in bile acid metabolism, intestinal homeostasis, and intestinal ischemia–reperfusion (I/R) injury. The authors clarified the potential effects of FXR on intestinal epithelial cell tolerance to intestinal I/R injury and revealed the underlying mechanisms. [Shock] Abstract Distinct Populations of Embryonic Epithelial Progenitors Generate Lgr5+ Intestinal Stem Cells Scientists investigated the cellular heterogeneity within the mouse embryonic midgut epithelium at the molecular and functional levels. Cell fate mapping analysis revealed that multiple early embryonic epithelial progenitors give rise to Lgr5+ intestinal stem cells. [Dev Biol] Abstract XRCC5 Cooperates with p300 to Promote Cyclooxygenase-2 Expression and Tumor Growth in Colon Cancers Investigators identified XRCC5 as a binding protein of the cyclooxygenase (COX)-2 gene promoter in colon cancer cells with streptavidin-agarose pulldown assay and mass spectrometry analysis, and found that XRCC5 promoted colon cancer growth through modulation of COX-2 signaling. [PLoS One] Full Article Human colonic adenocarcinoma cells were treated with tumor necrosis factor α to investigate signaling mechanisms in vitro. Epithelially expressed aquaporin 3 expression was assessed by real-time PCR and radiolabeled glycerol uptake, with select inhibitors and a luciferase reporter construct used to further elucidate intracellular signaling. [Physiol Rep] Full Article | |
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REVIEWSEndocannabinoid-Related Compounds in Gastrointestinal Diseases The authors summarize the possible mechanisms linking the endocannabinoid system (ECS) to gastrointestinal (GI) disorders and describes the most recent advances in the manipulation of the ECS in the treatment of GI diseases. [J Cell Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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SCIENCE NEWSCelgene Corporation announced that Phase II data of investigational compound ozanimod in Crohn’s disease and ulcerative colitis was presented. [Press release from Celgene Corporation discussing research presented at the World Congress of Gastroenterology (WCOG) at American College of Gastroenterology (ACG) 2017, Orlando] Press Release Takeda Pharmaceutical Company Limited announced the presentation of data suggesting early symptomatic improvement in specific symptoms with Entyvioj® in patients with moderately to severely active ulcerative colitis or Crohn’s disease, particularly in biologic-naïve patients for whom other therapies have not worked well enough. [Press release from Takeda Pharmaceutical Company Limited discussing research presented at the World Congress of Gastroenterology (WCOG) at American College of Gastroenterology (ACG) 2017, Orlando] Press Release Study Results of ACT-101 in a Model of Inflammatory Bowel Disease (IBD) Presented Alpha Cancer Technologies Inc. announced the results of a study of ACT-101 (recombinant human alpha fetoprotein or rhAFP) in the treatment of IBD. [Press release from Takeda Pharmaceutical Company Limited discussing research presented at the World Congress of Gastroenterology (WCOG) at American College of Gastroenterology (ACG) 2017, Orlando] Press Release Ironwood Pharmaceuticals Presenting Linaclotide Data Ironwood Pharmaceuticals, Inc. announced that the company and its collaborators presented clinical data for linaclotide. [Press release from Ironwood Pharmaceuticals, Inc. discussing research presented at the World Congress of Gastroenterology (WCOG) at American College of Gastroenterology (ACG) 2017, Orlando] Press Release | |
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INDUSTRY NEWSAbbVie and Harpoon Therapeutics Announce Immuno-Oncology Research Collaboration AbbVie and Harpoon Therapeutics announced that they have entered an immuno-oncology research collaboration. The goal of the collaboration is to incorporate Harpoon’s tri-specific T-cell activating construct platform with AbbVie’s research-stage immuno-oncology targets to develop novel cancer therapeutics. [AbbVie Inc.] Press Release Lycera Corp. announced the initiation of the Phase IIa portion of the company’s Phase I/IIa ARGON study of its novel immuno-oncology therapeutic candidate, LYC-55716 is a first-in-class oral, selective retinoic acid-related orphan receptor-gamma (RORgamma) agonist, designed to reprogram the immune system in patients with advanced, relapsed or refractory solid tumors. [Lycera Corp.] Press Release | |
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POLICY NEWSRand Paul Takes a Poke at U.S. Peer Review Panels Senate Republicans have launched a new attack on peer review by proposing changes to how the U.S. government funds basic research. [ScienceInsider] Editorial Efforts to Save Leading Hungarian University Hit Hurdle The threatened Central European University in Budapest has been dealt a blow in its efforts to avert possible closure in Hungary. The country’s parliament voted to postpone, for a year, a decision that would allow the university to keep operating there. [Nature News] Editorial New Definitions of Scientific Units Are on the Horizon Revamped definitions of scientific units are on their way. In the biggest overhaul of the international system of units since its inception in 1960, a committee is set to redefine four basic units — the ampere, the kilogram, the kelvin and the mole — using relationships to fundamental constants, rather than abstract or arbitrary definitions. [Nature News] Editorial Top Chinese University to Consider Social-Media Posts in Researcher Evaluations One of China’s most prestigious universities plans to give some articles in newspapers and posts on major social-media outlets the same weight as peer-reviewed publications when it evaluates researchers. [Nature News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Autophagy and Intestinal Inflammation (University of New Mexico) Research Technologist – Intestinal Stem Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Research Assistant – Intestinal Immune Responses to Infection (University of Dundee) Faculty Positions – Cancer Research (Huntsman Cancer Institute) Research Associate – Mechanical Cell Competition (University of Bristol) Faculty Position – Molecular Oncology (Moffitt Cancer Center) Postdoctoral Positions – Stem Cell and Cancer Biology (Johns Hopkins University) Researcher/Faculty Member – Cancer Biology (University of Cincinnati) Postdoctoral Opportunities – Biology of Colorectal Cancer (Albert Einstein College of Medicine) Postdoctoral Fellow – Gastric Stem Cells (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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