Intestinal Cell News Volume 3.43 | Nov 10 2017

TOP STORY

Autophagy Protein ATG16L1 Prevents Necroptosis in the Intestinal Epithelium

Intestinal organoids lacking ATG16L1 reproduced this loss in Paneth cells and displayed TNFα-mediated necroptosis, a form of programmed necrosis. This cytoprotective function of ATG16L1 was associated with the role of autophagy in promoting mitochondrial homeostasis. [J Exp Med] Abstract

(Ranked by impact factor of the journal)

Bacterial Colonization Stimulates a Complex Physiological Response in the Immature Human Intestinal Epithelium

Investigators demonstrated that the epithelium of human pluripotent stem cell-derived human intestinal organoids (HIOs) is globally similar to the immature human epithelium and they utilized HIOs to investigate complex host-microbe interactions in this naïve epithelium. [eLife] Abstract

Derangement of Intestinal Epithelial Cell Monolayer by Dietary Cholesterol Oxidation Products

This work investigated in an in vitro model the potential ability of a combination of dietary oxysterols representative of a hyper-cholesterol diet to induce the loss of intestinal epithelial layer integrity. [Free Radic Biol Med] Abstract

Identification of PMN-Released Mutagenic Factors in a Co-Culture Model for Colitis-Associated Cancer

Certain factors released by polymorphonuclear cells (PMN) may drive mucosal frameshift mutations resulting in microsatellite instability and cancer. The authors applied a co-culture system with PMNs and colon epithelial cells to identify such culprit factors. [Carcinogenesis] Full Article

Overexpression of dJmj Differentially Affects Intestinal Stem Cells and Differentiated Enterocytes

Overexpression of Drosophila Jumonji (dJmj) in intestinal stem cells (ISCs)/enteroblasts induced cell-autonomous ISC proliferation followed by differentiation, that is controlled by the Notch and EGFR pathway. [Cell Signal] Abstract

Bromoethylindole (BEI-9) Redirects NF-κB Signaling Induced by Camptothecin and TNFα to Promote Cell Death in Colon Cancer Cells

Scientists showed that a combination of BEI-9 with either camptothecin or tumor necrosis factor alpha (TNFα) enhances cell death. Using colorectal cancer cells, they examined the activation of NF-κB by drugs, the potential of BEI-9 for inhibiting drug-induced NF-κB activation, and the enhancement of cell death by combination treatments. [Apoptosis] Abstract

Depletion of MUC5B Mucin in Gastrointestinal Cancer Cells Alters Their Tumorigenic Properties: Implication of the Wnt/β-Catenin Pathway

Consequences of MUC5B knocking-down on cancer cells were studied with respect to in vitro proliferation, migration and invasion, and in vivo on tumor growth using a mouse subcutaneous xenograft model. [Biochem J] Abstract

Long Intergenic Non-Protein-Coding RNA 1567 (LINC01567) Acts as a “Sponge” against MicroRNA-93 in Regulating the Proliferation and Tumorigenesis of Human Colon Cancer Stem Cells

Primary colon cancer cells were maintained in serum-free medium to form spheres and CD133⁺/CD166⁺/CD44⁺ spheroid cells were selected using FACS technique. Investigators detected growth curve, colony formation, invasion and migration ability, and tumorigenicity of CD133⁺/CD166⁺/CD44⁺ cells. [BMC Cancer] Full Article

Overexpression of Lamin B1 Induces Mitotic Catastrophe in Colon Cancer LoVo Cells and Is Associated with Worse Clinical Outcomes

Researchers elucidated the influence of LMNB1 upregulation on colon cancer cell line after treatment with 5-FU. They indicated that overexpression of LMNB1 induced dose-dependent cell death mainly by mitotic catastrophe pathway. [Int J Oncol] Abstract

Emerging Tumor Spheroids Technologies for 3D In Vitro Cancer Modeling

Spheroids are of limited value in studying critical biological phenomenon such as tumor-stroma interactions involving extracellular matrix or the immune system. Therefore, a compelling need of tailoring spheroid technologies with physiologically relevant biomaterials or in silico models is emerging. [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Cleveland Clinic Earns NCI Grant to Develop Novel Disease Models of Colorectal Cancer, Including “Body-on-a-Chip” Technology

Cleveland Clinic researcher Emina Huang, M.D. has been awarded a collaborative five-year, $2.6 million grant from the National Cancer Institute (NCI) to create innovative models of colorectal cancer that will enhance understanding of how the disease develops and spreads. [Cleveland Clinic] Press Release

RedHill Biopharma Announces Last Patient Enrolled in the Phase III Study with RHB-104 for Crohn’s Disease

RedHill Biopharma Ltd. announced that the last patient has been enrolled in the Phase III study with RHB-104 for Crohn’s disease. [RedHill Biopharma Ltd.] Press Release

WHO Calls for Restrictions on Use of Antibiotics in Food Animal Production

The World Health Organization (WHO) is urging countries to restrict the amount of antibiotics given in food animal production by prohibiting their routine use in growth promotion and disease prevention. The recommendation is one of a number the WHO issued aimed at preserving the effectiveness of antibiotics. [STAT News] Editorial

UK Government Appoints Next Chief Scientific Adviser

Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial

Indian Scientists Urged to Speak Out about Pseudoscience

A leading Indian science-advocacy group is urging the country’s researchers to speak out against pseudoscience, which it fears has gained a foothold in the past few years, partly through support from some agencies of the Indian government. [Nature News] Editorial

NEW European Society for Medical Oncology (ESMO) 2018 Congress
October 19-23, 2018
Munich, Germany

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Positions – Stem Cell and Cancer Biology (Johns Hopkins University)

NEW PhD Studentships – MRC WIMM Prize (University of Oxford)

NEW Postdoctoral Fellows – Gastrointestinal Cancers (Baylor Scott & White Health)

NEW Postdoctoral Position – Mucosal Immunology/Inflammatory Bowel Disease (Weill Cornell Medicine)

NEW Postdoctoral Position – Innate Immune Signaling in the Developing Intestine (UConn Health)

NEW Postdoctoral Fellow – Mucosal Immunology (University of Lorraine)

Postdoctoral Training Fellows – Inflammatory Responses and Cancer (The Francis Crick Institute)

Postdoctoral Position – Autophagy and Intestinal Inflammation (University of New Mexico)

Research Associate – Mechanical Cell Competition (University of Bristol)

Faculty Position – Molecular Oncology (Moffitt Cancer Center)

Postdoctoral Positions – Stem Cell and Cancer Biology (Johns Hopkins University)

Researcher/Faculty Member – Cancer Biology (University of Cincinnati)

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