Intestinal Cell News Volume 3.46 | Dec 1 2017

TOP STORY

Quiescence Exit of Tert⁺ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

Employing a Tert knockin mouse model, researchers found that Tert⁺ cells are long-term label-retaining self-renewing cells, which are partially distinguished from the previously identified +4 intestinal stem cells. [Cell Rep] Full Article | Graphical Abstract

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Cysteine-Rich Intestinal Protein 1 Silencing Inhibits Migration and Invasion in Human Colorectal Cancer

Researchers investigated the expression profile and functions of cysteine-rich intestinal protein 1 (CRIP1) in colorectal cancer. To examine the protein expression level of CRIP1, immunohistochemistry was performed on 56 pairs of colon cancer tissue samples. Western blotting was performed to investigate CRIP1 protein expression in four colon cancer cell lines. [Cell Physiol Biochem] Full Article

Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability Are Partially Mediated by CK8 Upregulation

The authors investigated the regulatory effects of corticotropin-releasing factor on the permeability of human intestinal epithelial cells through the CK8-mediated tight junction. The expression levels of corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2 on the HT29 cell surface were determined by immunofluorescence, RT-PCR, and Western blotting. [Cell Physiol Biochem] Full Article

Long Non-Coding RNA LINC00152 Promotes Cell Proliferation, Metastasis, and Confers 5-FU Resistance in Colorectal Cancer by Inhibiting miR-139-5p

Scientists explored the roles of LINC00152 in cellular function and its possible molecular mechanism. They discovered that LINC00152 was overexpressed in CRC tissues and negatively related to the survival time of CRC patients. [Oncogenesis] Full Article

De Novo Expression of Human Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) in Colon Adenocarcinoma Inhibits the Differentiation of Colonic Epithelium

To investigate the function of GalNAc-T6 in colon cancer, scientists used precise gene targeting to produce isogenic colon cancer cell lines with a knockout/-rescue system for GalNAc-T6. [J Biol Chem] Abstract | Full Article

Over-Expression of miR-146b and Its Regulatory Role in Intestinal Epithelial Cell Viability, Proliferation, and Apoptosis in Piglets

Investigators evaluated the effects of miR-146b on cell viability, proliferation, and apoptosis in IPEC-J2 cells. [Biol Direct] Full Article

Suppression of Cancer Stemness by Upregulating Ligand-of-Numb Protein X1 in Colorectal Carcinoma

LNX1 was identified as a negative regulator of cancer stemness in CRC, which was downregulated in colonospheres or side population cells. [PLoS One] Full Article

Induction of Colon and Cervical Cancer Cell Death by Cinnamic Acid Derivatives Is Mediated through the Inhibition of Histone Deacetylases (HDAC)

Naturally occurring cinnamic acids derivatives were screened for HDAC inhibitory effect using in silico docking method which identified cinnamic acids as potential candidates. [PLoS One] Full Article

Ginsenoside Rg3 Inhibits Colorectal Tumor Growth via Down-Regulation of C/EBPβ/NF-κB Signaling

Investigators determined the antitumor effects of ginsenoside Rg3 using human colorectal cells in vitro and Xenograft tumor model of human colon cancer in vivo. [Biomed Pharmacother] Abstract

Curcumin Mediated Down-Regulation of α_vβ₃ Integrin and Up-Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) in Erlotinib Resistant SW480 Colon Cancer Cells

The authors investigated the effect of combination therapy using curcumin- and erlotinib-loaded nanoparticles on the expression of α_vβ₃ integrin and PDK4 in an erlotinib-resistant SW480 colon cancer cell line. [Phytother Res] Abstract

Cellular Senescence in Gastrointestinal Diseases: From Pathogenesis to Therapeutics

Scientists provide an introduction to cellular senescence, addressed particularly to gastroenterologists and hepatologists, and discuss the implications of senescence for the pathogenesis of malignant and nonmalignant gastrointestinal and hepatobiliary diseases. They conclude with an outlook on how modulation of cellular senescence might be used for therapeutic purposes. [Nat Rev Gastroenterol Hepatol] Abstract

Pathology and Genetics of Hereditary Colorectal Cancer

The authors summarize the genetic and pathological alterations in hereditary CRC syndromes. [Pathology] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Universal Diagnostics Starts Clinical Study of Novel Blood Screening Test for Early Detection of Colon Cancer with Imperial College Healthcare NHS Trust

Universal Diagnostics announced the start of a prospective clinical study of its colorectal screening blood test in collaboration with Imperial College Healthcare NHS Trust. [Universal Diagnostics (Business Wire, Inc.)] Press Release

Regen BioPharma, Inc. Begins In Vivo Assessment of Small Molecule Agonists to NR2F6 Nuclear Receptor

Regen BioPharma Inc. initiated in vivo and ex vivo assessments to determine the effects of some of the company’s NR2F6 small molecule agonists in live rats and in tissues derived from humans and rats. The NR2F6 nuclear receptor has been identified as a potentially very important immune cell inhibitor and cancer stem cell differentiator. [Regen BioPharma Inc. (PR Newswire Association LLC)] Press Release

Health Agency Reveals Scourge of Fake Drugs in Developing World

One in ten medicines in developing countries is fake or substandard, data from the World Health Organization suggest. Malaria drugs and antibiotics are among the most commonly reported, the agency found. But the problem extends to a variety of medications, including those for cancer, heart disease and HIV, as well as contraceptives and painkillers. [Nature News] Editorial

China to Roll Back Regulations for Traditional Medicine Despite Safety Concerns

Support for traditional medicine in China goes right to the top. President Xi Jinping has called this type of medicine a “gem” of the country’s scientific heritage and promised to give alternative therapies and Western drugs equal government support. The country is taking dramatic steps to promote these cures even as researchers raise concerns about such treatments. [Nature News] Editorial

NEW World Vaccine Congress Washington 2018
April 3-5, 2018
Washington, D.C., United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researchers – Stem Cell Metabolism (University of Helsinki)

Group Leader – Cancer Biology (University of Cambridge)

Postdoctoral Fellow – Inflammatory Bowel Disease (Emory University)

Research Assistant – Organoid Research (Friedrich Miescher Institute for Biomedical Research)

PhD Student – Stem Cells of the Intestine and the Stomach (German Cancer Research Center)

Postdoctoral Fellow – Modeling Physical Processes Underlying Digestion (Massey University)

PhD Studentships – MRC WIMM Prize (University of Oxford)

Postdoctoral Fellows – Gastrointestinal Cancers (Baylor Scott & White Health)

Postdoctoral Position – Mucosal Immunology/Inflammatory Bowel Disease (Weill Cornell Medicine)

Postdoctoral Position – Innate Immune Signaling in the Developing Intestine (UConn Health)

Postdoctoral Fellow – Mucosal Immunology (University of Lorraine)

Postdoctoral Position – Autophagy and Intestinal Inflammation (University of New Mexico)

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