Intestinal Cell News 4.02 January 19, 2018 | |
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TOP STORYThe authors showed that, in intestinal stem cell lineages in adult Drosophila, in which the Delta-Notch-signaling-guided progenitor cell differentiation into enterocytes is the default mode, the specification of enteroendocrine cells is initiated by transient Scute activation in a process driven by transcriptional self-stimulation combined with a negative feedback regulation between Scute and Notch targets. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Mutant p53 Gain of Function Underlies High Expression Levels of Colorectal Cancer Stem Cells Markers Investigators examined whether oncogenic mutant p53 proteins may augment colorectal cancer stem cells phenotype. By genetic manipulation of mutant p53 in several cellular systems, they demonstrated that mutant p53 enhances colorectal tumorigenesis. [Oncogene] Full Article Scientists showed that endothelial isoenzyme (eNOS) was significantly upregulated in VilCreERT2 Apcfl/+ and VilCreERT2 Apcfl/fl mouse intestinal tissue, with intense immunostaining in hyperproliferative crypts. Similarly, the more invasive VVilCreERT2 Apcfl/+ Ptenfl/+ mouse model showed an overexpression of eNOS in intestinal tumors whereas this isoform was not expressed in normal tissue. [BMC Biol] Full Article Knockdown of ecotropic viral integration site 1 in metastatic colon cancer cells and subsequent passage through matrigel not only increased the invading capacity but also induced an epithelial-mesenchymal transition-like morphological feature of the cells, such as spindle-shaped appearance and led to a significant reduction in the expression of the epithelial marker, E-CADHERIN and increase in the expression of the mesenchymal marker, N-CADHERIN. [Cell Death Dis] Full Article Researchers studied the involvement of three phosphatidylinositol 3-kinase-related kinase (PIKK) family members in colon cancer cell senescence and connection between DNA-damage-induced senescence and NF-κB-regulated SASP in p53-proficient and p53-deficient colon cancer cells treated with doxorubicin. [Cell Death Dis] Full Article An Orthotopic Mouse Model of Gastric Cancer Invasion and Metastasis Scientists developed an orthotopic mouse model whereby gastric cancer cell lines are tagged with luciferase and injected into the subserosal layer of the stomach. This allows for the monitoring of primary tumor growth and metastasis in real-time as well as quantitation of the degree of tumor invasion through the stomach wall by immunohistochemistry. [Sci Rep] Full Article The authors identified critical molecules involved in spheroid formation in different cancer cell lines. They present here a simple, powerful and broadly applicable method to generate new sublines of tumor cell lines to study loss of cell-cell adhesion in cancer progression. [Sci Rep] Full Article Investigators found no obvious morphological changes between the S phase and G2 phase in mice intestinal epithelial cells. The G2 phase could be identified by Brdu incorporation resistance, marginal and scattered foci of histone H3 phosphorylated at Ser10, and relatively intact Golgi ribbon. [Cell Cycle] Abstract The authors report that miR-186-5p share a lower expression in colorectal cancer cell lines than in normal colonic epithelial cell line NCM460. miR-186-5p overexpression inhibits proliferation, metastasis and epithelial-to-mesenchymal transition of colorectal cancer cell line LoVo. [Arch Biochem Biophys] Abstract Intestinal Epithelial Cell-Specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis Researchers observed that intestinal epithelial cells, which establish the first-line barrier and regulate gut immunity, selectively expressed α-MII with minimal expression of its isozyme, alpha-mannosidase IIx. [Cell Struct Funct] Abstract | Full Article | |
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REVIEWSRole of the IL-33/ST2L Axis in Colorectal Cancer Progression Recent studies have provided overwhelming evidence that the interleukin-33 (IL-33)/ST2L axis plays important roles in colorectal cancer (CRC) progression. The authors summarize the role of the IL-33/ST2L axis in the ulcerative colitis and CRC microenvironments. [Cell Immunol] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSOutpost Medicine announced that the FDA has accepted two Investigational New Drug applications for its lead product candidate, OP-687. [Outpost Medicine (PR Newswire Association LLC.)] Press Release Adlai Nortye Enters into Global Licensing Agreement with Eisai for EP4 Antagonist Adlai Nortye Biopharma Co., Ltd. announced that it had entered into a Global Licensing Agreement with Eisai Co., Ltd. Under the terms of the Agreement, Adlai Nortye will have exclusive worldwide research, development, manufacture and commercialization rights to E7046, excluding Japan and part of Asia other than Mainland China. [Adlai Nortye Biopharma Co. Ltd.] Press Release | |
Read the Full Profile Meet Dr. Caroline Lindemans and explore her work using organoids to study intestinal repair | |
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POLICY NEWSBroad Institute Takes a Hit in European CRISPR Patent Struggle A decision from the European Patent Office (EPO) has put the Broad Institute in Cambridge, Massachusetts, on shaky ground with its intellectual property claims to the gene-editing tool CRISPR. EPO revoked a patent granted to the Broad for fundamental aspects of the technology, one of several of its patents facing opposition in Europe. [ScienceInsider] Editorial Brexit Vote Didn’t Spur Quick Exodus from UK Universities The number of European Union nationals working as academics at British universities increased slightly in the year that the United Kingdom voted to leave the EU, according to figures published by the Higher Education Statistics Agencyon. [Nature News] Editorial What a US Government Shutdown Would Mean for Science The National Institutes of Health would stop processing grants, but astronauts in space would keep working. [Nature News] Editorial In Trump’s First Year, Science Advice Sees a Marked Decline Since U.S. President Donald Trump took office, expert panels that provide key federal agencies with science advice have had fewer members and met less often than at any time since 1997, when the government started tracking such numbers, a new analysis concludes. [ScienceInsider] Editorial
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EVENTSNEW Annual Meeting of the Israel Stem Cell Society 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Position – Inflammatory Bowel Disease (KU Leuven) Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories) Postdoctoral Research Scientist – Cancer Research (The Cancer Research UK Beatson Institute) Senior Clinical Researcher – Gastro-Intestinal Pathology (University of Oxford) Postdoctoral Position – Intestinal Research (University of Pennsylvania) Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories) Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai) PhD Student – Stem Cells of the Intestine and the Stomach (German Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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