Intestinal Cell News 4.03 January 26, 2018 | |
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TOP STORYPhospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis Scientists reveal an unexpected link between membrane phospholipid remodeling and cholesterol biosynthesis and demonstrate that cholesterol itself acts as a mitogen for intestinal stem cells. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers assessed the effect of myeloid-specific or intestinal epithelial cell-specific deletion of Atg16l1 on chronic colitis triggered by the intestinal opportunistic pathogen Helicobacter hepaticus in mice. [Cell Host Microbe] Abstract | Graphical Abstract Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation Scientists demonstrated that the microbiota triggers basal Paneth cell-specific autophagy via induction of IFN-γ, a known trigger of autophagy, to maintain intestinal homeostasis. [Cell Host Microbe] Abstract | Graphical Abstract Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation Upon rotavirus infection in mice, intestinal stem cell (ISC) compartments robustly expanded and proliferating cells rapidly migrated. Infection resulted specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as was observed after ISC-targeted damage. [Cell Rep] Full Article | Graphical Abstract ROS Release by PPARβ/δ-Null Fibroblasts Reduces Tumor Load through Epithelial Antioxidant Response The authors present evidence of oxidative stress modulation by intestinal stromal PPARβ/δ, using a FSPCre-Pparb/d−/− mouse model and validated it with immortalized cell lines. [Oncogene] Full Article Researchers investigated whether toll-like receptor 4 in the intestinal epithelium regulates metabolic syndrome by coordinating interactions between the luminal microbiota and host genes that regulate metabolism. [Mucosal Immunol] Abstract The elevation in CDH1 expression was translated into functional parameters where cells lost their invasion and migratory characteristics and formed homogenous clusters through adhesion interactions. [Cell Death Dis] Full Article PLK1 Protects against Sepsis-Induced Intestinal Barrier Dysfunction In HT29 intestinal epithelial cells, lipopolysaccharide (LPS) stimulation induced cell apoptosis and inhibited cell proliferation. Overexpression of polo-like kinase 1 (PLK1) partly rescued the apoptosis and proliferation inhibition in HT29 cells caused by LPS. [Sci Rep] Full Article Guanylate Cyclase C Reduces Invasion of Intestinal Epithelial Cells by Bacterial Pathogens In vitro studies indicated that guanylate cyclase C signaling significantly reduced Salmonella invasion into Caco2-BBE monolayers. [Sci Rep] Full Article PIK3R3 Promotes Chemotherapeutic Sensitivity of Colorectal Cancer through PIK3R3/NF-kB/TP Pathway Investigators showed that phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) could enhance 5-fluorouracil induced apoptosis by regulating the expression of thymmidine phosphorylase (TP). [Cancer Biol Ther] Abstract | |
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REVIEWSPersonalized Cancer Medicine: An Organoid Approach Scientists highlight the advantages, challenges, and translational potential of tumor organoids in personalized cancer therapy and focus on gene–drug associations, drug response prediction, and treatment selection. [Trends Biotechnol] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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SCIENCE NEWSTaiho Oncology, Inc. and Servier announced clinical data for LONSURF® for the treatment of patients with mCRC who have been previously treated with fluropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild type, an anti-EGFR therapy. [Press release from Taiho Oncology, Inc. discussing research presented at the ASCO 2018 Gastrointestinal Cancers Symposium (ASCO-GI), San Francisco] Press Release | |
Watch Now Dr. Sylvia Boj details the use of organoids as model systems in drug screening and personalized medicine. | |
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INDUSTRY NEWSSynergy Pharmaceuticals Inc. announced that the FDA has approved TRULANCE® 3 mg tablet for the once-daily treatment of IBS-C in adults. [Synergy Pharmaceuticals Inc.] Press Release Bristol-Myers Squibb company announced new data from a cohort of the Phase II CheckMate -142 trial evaluating Opdivo and Yervoy for the treatment of patients with DNA mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer. [Bristol-Myers Squibb Company] Press Release | |
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POLICY NEWSGerman Scientists Hope for Windfall from Incoming Government Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial
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EVENTSNEW Intestinal Organoid Virtual Training Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science) NEW Postdoctoral Research Associate – Cancer Biology (King’s College London) Postdoctoral Position – Inflammatory Bowel Disease (KU Leuven) Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories) Postdoctoral Research Scientist – Cancer Research (The Cancer Research UK Beatson Institute) Senior Clinical Researcher – Gastro-Intestinal Pathology (University of Oxford) Postdoctoral Position – Intestinal Research (University of Pennsylvania) Postdoctoral Fellowship – Mouse Tumor Biology (Canadian Nuclear Laboratories) Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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