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Pulmonary Cell News| Intestinal Cell News 4.26 July 13, 2018 | |
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TOP STORYErbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer Knockdown of erbin disrupted epithelial cell polarity and increased cell proliferation in 3D culture. In addition, silencing erbin resulted in increased amplitude and duration of signaling through Akt and RAS/RAF pathways. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)SMAD4 Suppresses WNT-Driven De-Differentiation and Oncogenesis in the Differentiated Gut Epithelium Simultaneous loss of SMAD4 and activation of the WNT pathway led to de-differentiation and rapid adenoma formation in differentiated tissue. Transcriptional profiling revealed acquisition of stem cell characteristics, and co-labeling indicated that cells expressing differentiated enterocyte markers entered the cell cycle and re-expressed stem cell genes upon simultaneous loss of SMAD4 and activation of the WNT pathway. [Cancer Res] Abstract Researchers investigated the physiopathological implications of Rac1b in intestinal inflammation and carcinogenesis in vivo. The ectopic expression of Rac1b was induced in mouse intestinal epithelial cells after crossing Rosa26-LSL-Rac1b and villin-Cre mice. [Oncogene] Abstract CPT1A-Mediated Fatty Acid Oxidation Promotes Colorectal Cancer Cell Metastasis by Inhibiting Anoikis Investigators identified that the fatty acid oxidation (FAO) pathway was activated in detached colorectal cancer (CRC) cells. Multiple genes in the FAO pathway, specifically the rate-limiting enzyme CPT1A, were upregulated in CRC cells grown in suspension. [Oncogene] Abstract Scientists identified the zinc finger transcription factor PLAGL2 as a let-7 target that regulates intestinal epithelial stem cell (IESC) fate. PLAGL2 drove an IESC expression signature, activated Wnt gene expression, and enhanced a TCF/LEF reporter in intestinal organoids. [Stem Cell Reports] Full Article | Graphical Abstract Researchers investigated the mechanism of resistance of PIK3CA‐mutant colorectal cancer cell (CRC) lines to gedatolisib, a dual PI3K/mTOR inhibitor. Out of a panel of 29 CRC cell lines, they identified 7 harboring one or more PIK3CA mutations; of these, 5 and 2 were found to be sensitive and resistant to gedatolisib, respectively. [Int J Cancer] Abstract Inhibition of the miR-192/215-Rab11-FIP2 Axis Suppresses Human Gastric Cancer Progression RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in gastric cancer cells. [Cell Death Dis] Full Article Paracellular Calcium Flux across Caco-2 Cell Monolayers: Effects of Individual Amino Acids Researchers investigated whether a mixture of amino acids (AA) and/or functionally distinct individual AA directly affect paracellular calcium absorption across an intestinal epithelial cell model. [J Nutr Biochem] Abstract Down-regulated paxillin inhibited cell proliferation and invasion in colon cancer through suppressing M2 macrophage polarization. PI3k/Akt inhibitor repressed M2 macrophage polarization through down-regulating paxillin. PI3k/Akt inhibitor inhibited the function of the macrophage in promoting cell proliferation and invasion of colon cancer through down-regulating paxillin. [Biol Chem] Abstract AhR Activation Protects Intestinal Epithelial Barrier Function through Regulation of Par-6 In T84 cells, overexpression of Par-6 caused intestinal barrier dysfunction. Lipopolysaccharide-induced intestinal epithelial barrier dysfunction and increase in Par-6 expression was prevented by aryl hydrocarbon receptor (AhR) activation. [J Mol Histol] Abstract Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
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REVIEWSThe authors describe the janus kinase-STAT pathway and analyze the efficacy and safety of new small molecules such as filgotinib, upadacitinib, TD-1473, peficitinib, and Pf-06651600/Pf-06700841, showing data from Phase I and II trials. [Expert Opin Investig Drugs] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSBavarian Nordic A/S announced that the first patient has been dosed in a Phase II study evaluating the combination therapy of its cancer vaccine, CV301, and Bristol Myers Squibb’s checkpoint inhibitor, nivolumab, for the treatment of patients with resectable hepatic-limited metastatic colorectal cancer. [Bavarian Nordic A/S] Press Release Seattle Genetics, Inc. announced dosing of the first patient in the Phase II innovaTV 207 clinical trial evaluating the activity, safety and tolerability of tisotumab vedotin as monotherapy in selected solid tumors with high Tissue Factor expression. [Seattle Genetics, Inc.] Press Release Vedanta Biosciences announced that it has received funding from the Crohn’s & Colitis Foundation, a non-profit organization dedicated to finding the cures for Crohn’s disease and ulcerative colitis. The funds will be used to advance Vedanta Biosciences’ new microbiome-derived therapeutic program for the treatment and potential interception of inflammatory bowel disease. [Vedanta Biosciences] Press Release | |
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POLICY NEWSIt’s Time to Burst the Biomedical Bubble in UK Research A new study calls for a rebalancing of research and innovation funding to better meet the UK’s economic, social and health needs. [The Guardian] Editorial Petition Asks AAAS to Remove Fellows with Sexual Harassment Records A petition by members of the scientific community asks the American Association for the Advancement of Science (AAAS) to remove fellows who have been found guilty of sexual harassment or assault. [The Scientist] Editorial Chinese Researchers to Get More Autonomy Over Lab Spending Chinese Premier Li Keqiang says the country will ease restrictive rules governing how research funds are used, and cut red tape for researchers. Revised rules are designed to help researchers focus on their work and compete with their counterparts globally. [Nature News] Editorial
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EVENTSNEW The American Society for Cell Biology (ASCB) Annual Meeting 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute) Postdoctoral Scholar – Molecular and Cell Biology (University of California, Berkeley) Assistant Professor – Cancer Biology (Université de Genève) Postdoctoral Research Position – Cancer Biology (Medical Research Council) Postdoctoral Fellow – Colorectal Cancer (Dalhousie University) PhD position – Inflammatory Bowel Disease (Universitätsmedizin Berlin) Postdoctoral Fellow Position – Intestinal Research (Vanderbilt University Medical Center) Postdoctoral Position – Cancer Biology and Metastasis (MD Anderson Cancer Center) Associate/Full Researcher – Cancer Biology (University of Hawaii Cancer Center) Postdoctoral Fellowship – Inflammatory Bowel Disease (European Molecular Biology Laboratory) Postdoctoral Position – Digestive Health (University of California, Irvine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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