Intestinal Cell News 4.28 July 27, 2018 | |
| |
TOP STORYEnteroendocrine Cells Switch Hormone Expression along the Crypt-to-Villus BMP Signaling Gradient Researchers showed that enteroendocrine cell (EEC) hormones are differentially expressed between crypts and villi. BMP4 signals altered the hormone expression profiles of individual EECs to resemble those found in the villus. [Nat Cell Biol] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Stimulation of a subset of isolated enteroendocrine cells lead to a rapid inward ionic current, which was diminished by Piezo2 knockdown and channel inhibitors. Conditional knockout of intestinal epithelial Piezo2 resulted in a significant decrease in mechanically stimulated epithelial secretion. [Proc Natl Acad Sci USA] Full Article Investigators revealed that FMSP-nanoparticles produced dose-dependent effects on cancer cells, FMSP-nanoparticles with dose of 1.25 µg/mL did not decrease cell survivability, whereas dosages of 12.5 µg/mL and 50 µg/mL respectively showed 23.59% and 59.47% decrease in the cancer cell survivability. [Artif Cells Nanomed Biotechnol] Abstract Verrucarin J significantly inhibited AKT/HCT 116 cell growth by acting on the AKT/NFκB/Bcl-2 signaling axis and initiated apoptotic signaling as was evident from increased expression of pro-apoptotic markers such as cleaved PARP, cleaved caspase 3, and cleaved caspase 9. [Cell Death Dis] Full Article The cytotoxicity of free doxorubicin (Dox) was slightly greater than that of Dox-loaded dual-sensitive polymeric drug conjugate (HA-SS-MP) micelles. Cytotoxicity of HA-SS-MP and Dox-loaded HA-SS-MP micelles was greater for cancer stem cells than for parental HCT116 colon cancer cells and L929 normal fibroblast cells. [Biomacromolecules] Abstract Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation Andrographolide treatment demonstrated significant expression of RASSF1A and PTEN tumor suppressor genes in colon cancer and other cancer cells, mouse tissues and organoids. Depletion of RASSF1A with siRNA limited cyclin D1 and BAX expression. [Cell Physiol Biochem] Full Article This study aimed to explore the mechanism of the sphingosine-1-phosphate /sphingosine-1-phosphate receptor 2 pathway in intestinal epithelial cells that participate in the intestinal barrier function. [Cell Physiol Biochem] Full Article TFF1 Antagonizes TIMP-1 Mediated Proliferative Functions in Gastric Cancer Scientists demonstrated that tissue inhibitor matrix metalloproteinase‐1 (TIMP1) mRNA expression was induced by TNF‐α and activation of NF‐κB whereas inhibition of NF‐κB using BAY11‐7082 led to inhibition of NF‐κB and downregulation of TIMP1. [Mol Carcinog] Abstract Coagulation Factor 9-Deficient Mice Are Protected against Dextran Sulfate Sodium-Induced Colitis Researchers identified expression of coagulation factor IX (FIX) protein in small intestinal epithelial cells. Cellular FIX protein expression was increased following stimulation with the bacterial Toll-like receptor agonists lipopolysaccharide, macrophage-activating lipopeptide-2 and Pam3CSK4. [Biol Open] Full Article Investigators further elucidated the anti-tumor potential of bacopaside II in colon cancer cells. Bacopaside II significantly reduced growth at ≥20 µM for HT-29 and ≥15 µM for SW480, SW620 and HCT116. [Cells] Full Article Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
| |
REVIEWSTargeting JAK-STAT Signal Transduction in IBD The authors provide an overview of the mode of action of jakinibs and provide a comprehensive overview of existing clinical studies. [Pharmacol Ther] Abstract Brief Summary of the Current Protocols for Generating Intestinal Organoids Intestinal organoids can be used in basic studies for understanding the mechanisms underlying intestinal development and diseases and will be applied in future transplantation therapy and drug discovery to treat intestinal diseases. [Dev Growth Differ] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
| |
INDUSTRY NEWSThe collaboration brings together Bristol-Myers Squibb and Tsinghua University’s respective scientific expertise and capabilities with a focus on validating new targets and generating early drug candidates for clinical development. [Bristol-Myers Squibb Company] Press Release RedHill Biopharma Ltd. announced that it has enrolled 400 of the planned total of 444 patients in the ongoing confirmatory Phase III study investigating TALICIA® for H. pylori infection. [RedHill] Press Release | |
| |
| |
POLICY NEWSPresident Trump can add another tick in the records column: he doubled the length of time that any modern president has gone without a science adviser. [Washington Post] Editorial The UK and Indian governments signaled their commitment to a deeper relationship by jointly announcing four new awards worth £4.8 million under the Civil Nuclear Energy program and seven new awards worth £10.8 million under Phase 2 of the Global research program on health. [GOV.UK] Editorial New Evidence USCIS Policies Increased Denials of H-1B Visas New data show that in 2017, U.S. Citizenship and Immigration Services (USCIS) denied many more H-1B petitions and issued numerous costly Requests for Evidence to stop highly educated foreign nationals from working in America. [Forbes Media LLC] Editorial
| |
EVENTSNEW 60th American Society of Hematology (ASH) Annual Meeting & Exposition Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Fellow – Colon Cancer (Vanderbilt University Medical Center) NEW Senior Research Scientist – Cancer Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute) Postdoctoral Scholar – Molecular and Cell Biology (University of California, Berkeley) Assistant Professor – Cancer Biology (Université de Genève) Postdoctoral Fellow – Colorectal Cancer (Dalhousie University) PhD position – Inflammatory Bowel Disease (Universitätsmedizin Berlin) Postdoctoral Fellow Position – Intestinal Research (Vanderbilt University Medical Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Intestinal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|