Intestinal Cell News 4.34 September 7, 2018 | |
| |
TOP STORYInvestigators report on quantitative analyses of lineage tracing data from primary colon cancer xenograft tissue to assess cancer stem cell functionality in a human solid malignancy. [Nat Cell Biol] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Cancer spheroids secreted GAS6 via a lysyl-tRNA synthetase-dependent mechanism and caused the M2 polarization of macrophages, which activated the neighboring cells via secretion of FGF2/GROα/M-CSF to promote cancer dissemination under environmental remodeling via fibroblast-mediated laminins production. [J Clin Invest] Abstract | Full Article | Graphical Abstract Deletion of Ap4 decreased the number of colonic stem cells and increased the number of Paneth cells. Expression profiling revealed that intestinal stem cells signatures, as well as the Wnt/β-catenin and Notch signaling pathways were downregulated in Ap4-deficient adenomas and intestinal organoids. [Nat Commun] Full Article IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using EPS8-Dependent and Independent Mechanisms Scientists revealed that insulin receptor tyrosine kinase substrate (IRTKS) localized to the distal tips of actively growing microvilli via a mechanism that required its N-terminal inverse-bin-amphiphysin-Rvs domain. At microvillar tips, IRTKS promoted elongation through a mechanism involving its C-terminal actin-binding WH2 domain. [Curr Biol] Full Article | Graphical Abstract The authors showed that external stimulation with TGF-beta and the induction of TWIST1 converted CD44− non-cancer stem cells (CSCs) into the undifferentiated CD44+ CSCs, leading to the significant increment of CSCs in xenograft models. [Oncogene] Abstract Scientists report that high mobility group A2 (HMGA2) promoted cell cycle progression and inhibited apoptosis in colorectal cancer cells in vitro. They revealed that Hmga2 knock-in promoted chemical carcinogen-induced tumorigenesis in the intestine in vivo. [J Pathol] Abstract Myc-associated zinc finger (MAZ) expression increased tumorigenesis in an in vivo model of inflammation-induced colon cancer and was important for growth of human colon cancer cell lines in vitro and in vivo. MAZ was essential for cytokine and bacteria-induced STAT3 signaling in colon cancer cells. [Mol Cell Biol] Abstract Estrogen-related receptor α (ERRα) positively regulated the cell proliferation, migration and invasion of colon cancer cells, and suppression of ERRα completely reduced the epidermal growth factor (EGF) treatment-induced proliferation of colon cancer cells. Researchers showed that trametinib partially restrained the up-regulation of ERRα induced by EGF treatment, and ERRα inhibition increased the sensitivity of colon cancer cells to trametinib. [J Exp Clin Cancer Res] Full Article The Krüppel Like Factor Dar1 Restricts the Proliferation of Drosophila Intestinal Stem Cells Overexpression of Dar1 inhibited intestinal stem cell (ISC) division and blocked the formation of ISC lineages. Investigators revealed that Dar1 negatively regulated the expression of several critical cell cycle genes. [FEBS J] Abstract Researchers showed that coordination between Wnt and BMP signaling activity was necessary and sufficient to maintain Lgr5+ intestinal stem cell (ISC) self-renewal. Using the GSK3 inhibitor CHIR-99021 and the BMP type I receptor inhibitor LDN-193189, they could maintain Lgr5+ ISCs without growth factors in vitro. [Cell Discov] Full Article Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
| |
REVIEWSThe Intestinal Stem Cell Niche: Homeostasis and Adaptations The authors review recent concepts and propose an active interconversion of the intestinal stem cell (ISC) niche between homeostasis and injury-adaptive states that is superimposed upon an equally dynamic equilibrium between active and reserve ISC populations. [Trends Cell Biol] Abstract Investigators delineate the involvement of the guanylate cyclase 2C/cGMP/phosphodiesterases signaling pathway in the homeostasis of intestinal epithelial cells. The events associated with dysregulation of this pathway during colorectal cancer tumorigenesis are also discussed. [Semin Cancer Biol] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
| |
INDUSTRY NEWSHutchison China MediTech Limited (Chi-Med) announced that fruquintinib capsules have been granted approval for drug registration by the National Medical Products Administration of China for the treatment of metastatic colorectal cancer patients, who have failed at least two prior systemic antineoplastic therapies including fluoropyrimidine, oxaliplatin and irinotecan, with or without prior use of anti-vascular endothelial growth factor or anti-epidermal growth factor receptor therapies. [Hutchison China MediTech Limited] Press Release Abivax announced topline results from its Phase IIa clinical trial, ABX464-101. This clinical trial was conducted in 32 patients for induction treatment of moderate-to-severe ulcerative colitis, refractory to anti-TNF monoclonal antibodies or corticosteroids. [ABIVAX] Press Release Celyad announced the successful injection of the first patient under the amended protocol of the THINK trial, which assesses treatment with CYAD-01 after a non-myeloablative preconditioning chemotherapy regimen of cyclophosphamide and fludarabine in refractory metastatic colorectal cancer patients. [Celyad] Press Release PvP Biologics Announces First-in-Human Clinical Trials for a Novel Therapeutic for Celiac Disease PvP Biologics, Inc. announced the initiation of two first-in-human clinical trials for Kuma062, a product candidate for the treatment of celiac disease. Kuma062 is a uniquely engineered, recombinant enzyme that is active under acidic stomach conditions and has high specificity for the parts of gluten that cause the autoimmune reaction leading to celiac disease. [PVP BIOLOGICS, INC.] Press Release NOXXON Pharma N.V. announced that patient recruitment has been completed in the ongoing clinical trial testing NOX-A12 alone and subsequently in combination with Merck & Co./MSD’s PD-1 inhibitor Keytruda® in metastatic, microsatellite stable pancreatic and colorectal cancer patients. [NOXXON Pharma N.V.] Press Release | |
| |
| |
POLICY NEWSPeer Reviewers Unmasked: Largest Global Survey Reveals Trends Scientists in developed countries provide nearly three times as many peer reviews per paper submitted as researchers in emerging nations, according to the largest ever survey of the practice. [Nature News] Editorial PNAS to Stop Publishing Its Print Edition in 2019 PNAS announced on Twitter that the publication would discontinue its print edition come January, and in July 2019, the journal will extend the page limit on manuscripts. [The Scientist] Editorial The Trump administration’s restrictions on hiring foreign scientists are making it more difficult for the agency to attract top scientific talent, a top FDA official said. “[The policy] definitely has created an additional challenge, I think, for us,” said Melanie Keller, the FDA’s acting associate commissioner for scientific and clinical recruitment. [STAT News] Editorial
| |
EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Colon Cancer Research (Vanderbilt University Medical Center) Postdoctoral Research Scientist – Gastrointestinal Disorder Research (Quadram Institute Bioscience) Postdoctoral Fellow – Irritable Bowel Syndrome (University of Bergen) Senior Scientific Officer – Colorectal Cancer (Cancer Research UK Beatson Institute) PhD Student – Colorectal Cancer (German Cancer Research Center) Postdoctoral Scholar – Intestinal Research (Penn State College of Medicine) Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Intestinal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|