Intestinal Cell News Volume 4.43 | Nov 9 2018

TOP STORY

Drosophila Intestinal Stem and Progenitor Cells Are Major Sources and Regulators of Homeostatic Niche Signals

The authors used gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibited stem/progenitor-specific expression and had regulatory regions bound by both intrinsic and extrinsic transcription factors. [Proc Natl Acad Sci USA] Full Article

(Ranked by impact factor of the journal)

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

Investigators demonstrated that M2 macrophage-regulated colorectal cancer (CRC) cell migration and invasion was dependent upon M2 macrophage-derived exosomes (MDE). MDE displayed a high expression level of miR-21-5p and miR-155-5p, and MDE-mediated CRC cell migration and invasion depended on these two miRNAs. [Cancer Res] Abstract | Full Article

NAPE-PLD Controls OEA Synthesis and Fat Absorption by Regulating Lipoprotein Synthesis in an In Vitro Model of Intestinal Epithelial Cells

Researchers assessed the involvement of N-acyl-phosphatidylethanolamine-specific phospholipase D (NAPE-PLD), which could directly release fatty acid ethanolamides from NAPE, in intestinal oleoylethanolamide synthesis and lipid metabolism. [FASEB J] Abstract

Different Responses of Colorectal Cancer Cells to Alternative Sequences of Cetuximab and Oxaliplatin

Scientists tested the effect of the EGFR antibody cetuximab in different sequential combinations with oxaliplatin on the growth of colorectal cancer cells in vitro and in vivo. [Sci Rep] Full Article

Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment

A selective colon cancer cell therapy was effectively achieved with catalase-mediated intra-cellular heterogeneous Fenton reactions triggered by cellular uptake of SnFe₂O₄ nanocrystals. The treatment was proven effective for eradicating colon cancer cells, whereas it was benign to normal colon cells, thus effectively realizing selective colon cancer cell therapeutics. [Sci Rep] Full Article

Graphene Oxide Immobilized PLGA‐Polydopamine Nanofibrous Scaffolds for Growth Inhibition of Colon Cancer Cells

A novel graphene oxide (GO) immobilized poly (lactide‐co‐glycolic acid) (PLGA) nanofibrous scaffold assisted by polydopamine (PLGA‐PDA‐GO) was developed for growth inhibition of HT‐29 colon cancer cells. The interactions between GO and PDA were attributed to a π-π conjugate interaction and electrostatic attraction. [Macromol Biosci] Abstract

FAPP2 Promotes Tumor Cell Growth in Human Colon Cancer through Activation of Wnt Signaling

Disruption of phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2) by CRISPR/Cas9 technique in colon cancer cells led to an attenuated effect on cell growth analyzed by CCK8 and colony formation assays. Meanwhile, the tumorigenicity of FAPP2 downregulated cells also decreased in nude mice model. [Exp Cell Res] Abstract

Ginsenoside Rb1 Promotes Intestinal Epithelial Wound Healing through ERK and Rho Signaling

The colon epithelial regeneration ratio in the daikenchuto‐treated rats was significantly higher than that in the control rats. Daikenchuto, ginseng, and ginsenoside Rb1 enhanced wound healing, and the ginsenoside Rb1‐induced enhancement was inhibited by ERK and Rho inhibitors. [J Gastroenterol Hepatol] Abstract

Six-Transmembrane Epithelial Antigen of the Prostate 1 Protects against Increased Oxidative Stress via a Nuclear Erythroid 2-Related Factor Pathway in Colorectal Cancer

A loss-of-function approach in cultured colorectal cancer cell lines revealed that six-transmembrane epithelial antigen of the prostate 1 silencing suppressed cell growth and increased reactive oxygen species production, followed by apoptosis, through an intrinsic pathway. [Cancer Gene Ther] Abstract

Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News.

Intestinal Fibrosis

Scientists summarize the current status of knowledge regarding the mechanisms implicated in gut fibrosis with a clinical approach, also focusing on possible targets of antifibrogenic therapies. [Mol Aspects Med] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Gut Stem Cells Offer Clues for Preventing Tumors in Inherited Bowel Cancer

Treating pre-cancerous stem cells at an early stage could be key to preventing bowel cancer in people born with a very high risk of the disease, according to a study in mice presented. [Press release from National Cancer Research Institute discussing research presented at 2018 NCRI Cancer Conference, Glasgow] Press Release

Meet Dr. Caroline Lindemans and explore her work using organoids to study intestinal repair. Read the Full Profile

Amgen And Provention Bio Announce Co-Development Collaboration in Celiac Disease

Amgen and Provention Bio, Inc. announced a licensing and co-development agreement for AMG 714, identified by Provention as PRV-015. AMG 714 is a novel anti-IL-15 monoclonal antibody being developed for the treatment of gluten-free diet non-responsive celiac disease. [Amgen] Press Release

The First Patient Included in Pledpharma’s Global Phase III Program for Pledox^®

PledPharma AB announced that the first patient has been enrolled in the company’s global Phase III program with the company’s drug candidate PledOx^®. [PledPharma AB (GlobeNewswire, Inc.)] Press Release

Bavarian Nordic Announces Initiation of Clinical Trial Evaluating the Combination Therapy of CV301 and Durvalumab in Metastatic Colorectal and Pancreatic Cancers

Bavarian Nordic A/S announced that the first patient has been dosed in a clinical study evaluating CV301, the company’s targeted immunotherapy candidate, and durvalumab, AstraZeneca’s PD-L1 inhibitor, in combination with maintenance chemotherapy for patients with metastatic colorectal or pancreatic cancers. [Bavarian Nordic A/S] Press Release

Scientists Struggle with Confusing Journal Guidelines

Globally, more than two-thirds of researchers find it difficult to prepare manuscripts and to respond to peer-review comments, finds a survey of nearly 7,000 researchers from over 100 countries. [Nature News] Editorial

Open-Access Plan Draws Online Protest

Hundreds of scientists are pushing back against Plan S, a plan to crack down on scholarly journals’ paywalls, launched 2 months ago by 11 national research funders in Europe. In an open letter published on 5 November, about 800 signatories say they support open access—making papers available free to all readers online—but condemn Plan S as “too risky for science”. [ScienceInsider] Editorial

Sanger Whistle-Blowers Dispute Findings That Cleared Management of Bullying

Current and former employees say investigation at the Wellcome Sanger Institute was flawed; the genomics powerhouse stands by the findings. [Nature News] Editorial

NEW Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity
February 18-22, 2019
Breckenridge, Colorado, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Pesticide Exposure and Effects on Colorectal Cancer (Luxembourg Institute of Health)

NEW PhD Studentship – Colorectal Cancer (Institute of Cancer Research)

Postdoctoral Fellow – Organoid Modeling of Bacterial Infections (Uppsala University)

Associate Professor – Oncology (University of California, Davis)

Postdoctoral Fellow – Patient Derived Organoids (Rutgers Cancer Institute of New Jersey)

Postdoctoral Fellow – Intestinal & Colonic Stem Cell Research (Albert Einstein College of Medicine of Yeshiva University)

PhD Studentship – Gastrointestinal Adenocarcinomas (University of Cambridge)

Postdoctoral & Research Associate Positions – Biology of Intestinal & Colon Stem Cells (Johns Hopkins University)

Postdoctoral Position – Dendritic Cell Biology & Antigen Presentation (Weill Cornell Medicine)

Postdoctoral Position – Paneth Cells (Erasmus MC Cancer Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Intestinal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.