Intestinal Cell News 5.37 October 4, 2019 | |
| |
TOP STORYNotch and EGFR Regulate Apoptosis in Progenitor Cells to Ensure Gut Homeostasis in Drosophila Researchers showed that regulation of the number of enterocyte-committed progenitor cells in the adult Drosophila involved a caspase-mediated physiological apoptosis, which adaptively eliminated excess enteroblast cells produced by intestinal stem cells (ISCs) and, when blocked, could also lead to tumorigenesis. [EMBO J] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)RORα Is Crucial for Attenuated Inflammatory Response to Maintain Intestinal Homeostasis Transcriptome analysis revealed that deletion of retinoic acid-related orphan receptor α (RORα) led to up-regulation of NF-κB target genes in intestinal epithelial cells. Chromatin immunoprecipitation analysis revealed corecruitment of retinoic acid-related orphan receptor α (RORα) and histone deacetylase 3 on nuclear factor κB target promoters and subsequent dismissal of CREB binding protein and bromodomain-containing protein 4 for transcriptional repression. [Proc Natl Acad Sci USA] Abstract The authors investigated the expression levels of miR-532-3p and found that it was in situ downregulated both in colorectal adenoma and colorectal cancer (CRC). Moreover, it functioned as a sensitizer for chemotherapy in CRC by inducing cell cycle arrest and early apoptosis via its activating effects on p53 and apoptotic signaling pathways. [Cell Death Dis] Full Article Investigators found that intestinal stem cell expression, Wnt activity and intestinal regeneration were all decreased in both mice with experimental necrotizing enterocolitis (NEC) and in infants with acute active NEC. Moreover, intestinal organoids derived from NEC-injured intestine of both mice and humans failed to maintain proliferation and presented more differentiation. [Cell Death Dis] Full Article Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer Scientists discovered that facilitated chromatin transcription (FACT) complex facilitated fluorouracil (5-FU) repair in DNA via promoting the recruitment and acetylation of APE1 to damage sites in chromatin. Downregulation of FACT affected 5-FU damage repair in DNA and sensitized dMMR colorectal cancer cells to 5-FU. [Mol Cancer Ther] Full Article Scientists showed that Wnt3 was upregulated in human colorectal cancer (CRC) tissues and was essential for the CRC progression. Knockdown of Wnt3 in human CRC cells delayed tumor formation in nude mouse xenografts through silencing of canonical Wnt pathway and glycolysis. [Front Pharmacol] Full Article Anti-Tumor Activity of Neratinib, a Pan-HER Inhibitor, in Gastric Adenocarcinoma Cells Anti-proliferative effects of neratinib were determined using a cell proliferation assay and crystal violet staining. Annexin V/PI staining, radiation therapy and anoikis resistance and wound healing assays were carried out to examine the effects of neratinib on apoptosis, radio-sensitivity and cell motility, respectively. [Eur J Pharmacol] Abstract Gene expression was evaluated by qRT-PCR or Western blot. Both in vitro and in vivo assays were conducted to probe LINC01420 function in prostate cancer. ChIP, RIP, and luciferase reporter assays were performed to determine relationships between genes. [Dig Dis Sci] Abstract Extract from Aloysia polystachya Induces the Cell Death of Colorectal Cancer Stem Cells The chemical characterization of extracts was performed by HPLC. Assays of cytotoxicity, apoptosis, migration and invasion, metalloproteases activity, clonogenic growth, tumorspheres formation, Hoechts efflux, pluripotency marker expression and sensitization to chemotherapeutic drugs were performed in vitro in human HCT116 and murine CT26 colorectal cancer cells. [Nutr Cancer] Abstract Cell proliferation, apoptosis, differential gene expression and KEGG pathway analysis, intestinal paracellular permeability, intestinal morphology, and expression of HSP and tight junction proteins, and p-activated protein kinase (AMPK) were determined. l-Arginine promoted cell proliferation and reduced apoptosis after heat exposure at an optimal concentration of 5 mmol. [Mol Biol Rep] Abstract Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
| |
REVIEWSOmega Fatty Acids and Inflammatory Bowel Diseases: An Overview The consumption of fatty acids may be related to a reduced risk of developing IBD. Many studies have shown the beneficial effects of ω3 as adjunctive in the treatment or prevention of ulcerative colitis or Crohn’s disease. [Int J Mol Sci] Full Article | Graphical Abstract Adhesion Mechanisms of Lactic Acid Bacteria: Conventional and Novel Approaches for Testing Lactic acid bacteria contribute the majority of microorganisms with probiotic properties. They have several important mechanisms for intestinal epithelial cell adhesion. In order to adhere to the intestinal cells, they generally use various structures such as flagella, pili, S layer proteins, lipoteichoic acid, exopolysaccharides and mucus binding proteins. [World J Microbiol Biotechnol] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
| |
INDUSTRY NEWSPrometheus Biosciences, Inc. announced that it has entered into a global, multi-target strategic collaboration with Takeda Pharmaceutical Company Limited to discover, develop, and commercialize novel therapies for inflammatory bowel disease. [Prometheus Biosciences, Inc.] Press Release Physician-Scientist Awarded NIH Grant Dr. Steven Jonas, clinical instructor of pediatrics in the division of pediatric hematology/oncology in the David Geffen School of Medicine at UCLA, has received a five-year $1.25 million grant from the National Institutes of Health through its High-Risk, High-Reward Research Program. [The University of California, Los Angeles] Press Release | |
| |
POLICY NEWS‘More Women Are Being Nominated’: Nobel Academy Head Discusses Diversity The Royal Swedish Academy of Sciences introduced measures that it hoped would tackle the issue by encouraging scientists to put forward a more diverse range of nominees. These included asking more women to suggest candidates, and altering the wording of the letter inviting nominations. [Nature News] Editorial Split Decisions: How Brexit Has Taken a Toll on Five Researchers On 23 June 2016, 34 million UK citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial Trump Set to Nominate Stephen Hahn as FDA Commissioner, Pending Vetting Process President Trump is set to nominate Dr. Stephen Hahn to lead the FDA, pending completion of the vetting process, according to two people familiar with the selection process. Hahn, an oncologist, is the chief medical executive at MD Anderson Cancer Center in Houston. [STAT News] Editorial
| |
EVENTSNEW AACR-KCA Joint Workshop on Precision Medicine Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Reserch Scientist – In Vivo Research on Wnt Signaling in Self-Renewel (Surrozen) NEW Chief Editor – Nature Ageing (Nature Research) Postdoctoral Researcher – IBS (Quadram Institute Bioscience) Postdoctoral Researcher – Systems Biology of Cancer (Max Planck Institute for Molecular Genetics) Postdoctoral Fellow – Intestinal Graft-versus-Host-Disease (Medical College of Wisconsin) Senior Researcher – Inflammatory Diseases (Genentech, Inc.) Postdoctoral Researcher – Microbiome in IBD (GIGA-Medical Genomics Unit) Principal Researcher – Systems Disease Biology (Boehringer Ingelheim) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Intestinal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|