Intestinal Cell News Volume 6.05 | Feb 14 2020

TOP STORY

Inflammation Mobilizes Copper Metabolism to Promote Colon Tumorigenesis via an IL-17-STEAP4-XIAP Axis

Scientists report an axis by which inflammatory cytokines, such as IL-17, drove cellular copper uptake via the induction of a metalloreductase, STEAP4. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

MEX3A Regulates Lgr5⁺ Stem Cell Maintenance in the Developing Intestinal Epithelium

The authors generated a Mex3a knockout mouse model and showed that this RNA-binding protein was crucial for the maintenance of the Lgr5⁺ intestinal stem cell pool, as its absence disrupted epithelial turnover during postnatal development and stereotypical organoid maturation ex vivo. [EMBO Rep] Full Article | Graphical Abstract

Intestinal Epithelial Cells Express Immunomodulatory ISG15 during Active Ulcerative Colitis and Crohn’s Disease

Scientists investigated how innate immunity and intestinal epithelial cell-specific pattern recognition receptor signaling could be involved in an enhanced type I interferon gene signature observed in colon epithelium from patients with active IBD, with a special focus on secreted ubiquitin-like protein ISG15. [J Crohns Colitis] Full Article

Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine

Investigators identified Sox100B, a Drosophila Sox E family transcription factor, as a critical regulator of adult intestinal stem cell differentiation. [Stem Cell Reports] Full Article | Graphical Abstract

GATA6 Enhances the Stemness of Human Colon Cancer Cells by Creating a Metabolic Symbiosis through Upregulating LRH-1 Expression

LRH‐1 was found as a direct target of GATA6, and its upregulation promoted stemness in both HCT-116 and HT-29 cells. [Mol Oncol] Abstract | Full Article

miR‐497‐5p Mediates Starvation‐Induced Death in Colon Cancer Cells by Targeting Acyl‐CoA Synthetase‐5 and Modulation of Lipid Metabolism

Acyl-CoA synthetase‐5 (ACSL5)‐related miRNAs were identified via TargetScan, and their impacts on ACSL5 and lipid content along with metabolic activity, cell cycle, migration, and invasion of colorectal cancer cells were examined, and subsequently compared with the transcriptome for better visualization of intracellular‐signaling networks. [J Cell Physiol] Abstract

LINC00961 Inhibits the Migration and Invasion of Colon Cancer Cells by Sponging miR‐223‐3p and Targeting SOX11

Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR‐223‐3p in colon cancer cells. [Cancer Med] Full Article

NCoR1 Protects Mice from Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells from Luminal Insult

Researchers performed in vivo and in vitro studies from control and intestinal epithelial cell specific NCoR1 deficient mice. [Cell Mol Gastroenterol Hepatol] Abstract | Full Article

BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells

Scientists screened several Toll-like receptor (TLR) 4 ligands and found that among them BGN was highly expressed in cancers and was involved in the epigenetic silencing of Siglec-7 ligands. [Cells] Abstract | Download Full Article | Graphical Abstract

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How Do Immune and Mesenchymal Cells Influence the Intestinal Epithelial Cell Compartment in Inflammatory Bowel Disease? Let’s Crosstalk About It!

The authors review the current literature looking at crosstalk between immune cells, stromal cells, and intestinal epithelial cells (IECs): how does the immune system potentially alter the intestinal stem cell niche, and how do IECs influence intestinal immunity? [J Leukoc Biol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

New Phase IIIb Interim Data from STARDUST Study Show Two-Thirds of Patients with Moderately to Severely Active Crohn’s Disease Achieved Clinical Remission after Two Doses of STELARA^® (Ustekinumab)

The Janssen Pharmaceutical Companies of Johnson & Johnson announced interim data from the Phase IIIb STARDUST study. [Janssen Global Services, LLC] Press Release

Bold Therapeutics to Initiate Phase Ib Trial of BOLD-100 in the Treatment of GI Cancers

Bold Therapeutics, Inc. announced that it has received clearance from Health Canada to initiate a Phase Ib trial of its first-in-class anti-resistance therapeutic, BOLD-100, in combination with FOLFOX for the treatment of gastric, pancreatic, colorectal and bile duct cancers. [Bold Therapeutics, Inc. (PR Newswire Association LLC.)] Press Release

Harvard, Yale Investigated for Undisclosed Foreign Funding

The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial

Popular Preprint Servers Face Closure Because of Money Troubles

The rise of preprint repositories has helped scientists worldwide to share results and get feedback quickly. But several platforms that serve researchers in emerging economies are struggling to raise money to stay afloat. Repositories like INA-Rxiv and IndiaRxiv boost regional science, but finding cash to run them is proving difficult. [Nature News] Editorial

NEW 7^th Microbiome R&D and Business Collaboration Forum
May 18-20, 2020
Rotterdam, The Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Inflammatory Bowel Disease (University of Copenhagen)

NEW Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Intestinal Immunity (The University of Chicago)

Postdoctoral Associate – Intestinal Immunology (The Scripps Research Institute)

PhD Student – Biology of Stem Cells (Dresden University of Technology)

Postdoctoral Position – Epigenetic Control by the Novel Histone Methyltransferase KMT9 (University of Freiburg)

Senior Scientist – Drug Concept Discovery (Boehringer Ingelheim)

Faculty Scientist Position – IBD Research (The University of Texas Health Science Center at Houston)

Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewel (Surrozen)

Principal Researcher – Systems Disease Biology (Boehringer Ingelheim)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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