Intestinal Cell News 6.07 February 28, 2020 | |
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TOP STORYSingle-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer To examine the relationship between aneuploidy and cancer progression, researchers analyzed a series of congenic cell lines that harbored single extra chromosomes. They found that across 13 different trisomic cell lines, 12 trisomies suppressed invasiveness or were largely neutral, while a single trisomy increased metastatic behavior by triggering a partial epithelial-mesenchymal transition. [Dev Cell] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)TRIM34 Attenuates Colon Inflammation and Tumorigenesis by Sustaining Barrier Integrity The authors identified a novel function of TRIM34 in goblet cells (GCs) in controlling inner mucus layer generation. Upon DSS treatment, TRIM34 deficiency led to a reduction in Muc2 secretion by GCs and subsequent defects in the inner mucus layer. [Cell Mol Immunol] Abstract Scientists observed that tumors with a functional mismatch repair system showed a predominant 5′-location of truncating RNF43 mutations, suggesting C-terminal truncations such as the most commonly reported p.G659fs mutation, did not affect β-catenin signaling. [Oncogene] Abstract The authors showed that colonic JMJD2D was induced by TNFα during dextran sulfate sodium-induced colitis. JMJD2D-deficient mice exhibited more severe colon damage and defective colon regeneration due to impaired Hedgehog signaling activation after colitis. [Oncogene] Abstract EMT Transcription Factor ZEB1 Alters the Epigenetic Landscape of Colorectal Cancer Cells In silico analysis was performed in combination with different in vitro and in vivo techniques to identify and verify novel epigenetic targets of ZEB1, and to proof the direct transcriptional regulation of SETD1B by ZEB1. [Cell Death Dis] Full Article Up-regulated POU6F2-AS2 promoted cell proliferation and cell cycle of colon cancer cells. Overexpression of POU6F2-AS2 inhibited the expression of miR-377 and then up-regulated the expression of BRD4. [J Cell Mol Med] Full Article The ex vivo generation of gastrointestinal organoids from crypt stem cells opens up the possibility of new research approaches investigating gastrointestinal diseases. Researchers used this technology to study differences between healthy controls and patients with celiac disease. [Sci Rep] Full Article Scientists investigated the deformability of three colorectal cancer (CRC) cell lines using a range of flow conditions. These cell lines offered a model for CRC metastatic progression; SW480 derived from primary adenocarcinoma, HT29 from a more advanced primary tumor and SW620 from lymph-node metastasis. [Sci Rep] Full Article Researchers developed an in vitro model of intestinal permeability using induced pluripotent stem cell (iPSC)-derived human intestinal organoids and human colonic organoids to study barrier dysfunction. [Int J Mol Sci] Full Article Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
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REVIEWSPathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease The authors describe inflammatory bowel disease as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system. [Nature] Abstract Organoid Models of Gastrointestinal Cancers in Basic and Translational Research Researchers review the current literature on organoid models of the most common gastrointestinal cancers, including colorectal cancer, gastric cancer, oesophageal cancer, liver cancer and pancreatic cancer, and their value in modeling tumor initiation, metastatic progression and therapy response. [Nat Rev Gastroenterol Hepatol] Abstract Epithelial Toll-Like Receptors and Their Role in Gut Homeostasis and Disease Investigators focus on the expression, regulation and functions of Toll-like receptors in the different intestinal epithelial lineages to analyze how epithelial recognition of bacteria participates in establishing homeostasis in the gut. [Nat Rev Gastroenterol Hepatol] Abstract Gastrointestinal Tract Modeling Using Organoids Engineered with Cellular and Microbiota Niches Scientists review the recent progress made in elucidating the crosstalk between gastrointestinal organoids and components of their microenvironment. [Exp Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSVBL Therapeutics announced the launch of a Phase II clinical trial of VB-111 in combination with nivolumab, an immune checkpoint inhibitor, in the treatment of metastatic colorectal cancer. This new study will investigate if priming with VB-111 can drive immune cells into the tumor and turn the colorectal tumor from immunologically “cold” to “hot.” [Vascular Biogenics Ltd.] Press Release Anokion SA announced the initiation of patient dosing in the company’s multi-center Phase I clinical trial to evaluate KAN-101, the company’s lead antigen-specific drug candidate, for the treatment of celiac disease. [Anokion SA] Press Release Takeda Pharmaceutical Company Limited announced that it has acquired PvP Biologics, Inc. following the conclusion of a Phase I proof-of-mechanism study of investigational medicine TAK-062 for the treatment of uncontrolled celiac disease. [Takeda Pharmaceutical Company Limited] Press Release | |
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POLICY NEWSFederal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten-year gap in data that now must be made publicly available. [STAT News] Editorial It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student Position – Intestinal Stem Cell Research (Karolinska Institutet) NEW Lab Manager – Intestinal Research (Howard Hughes Medical Institute) Postdoctoral Fellow Position – Gene Editing and Genomic Evolution (Northwestern University) Postdoctoral Position – Intestinal Microbiology and Ecology (Technical University of Denmark) Postdoctoral Position – Inflammatory Bowel Disease (University of Copenhagen) Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai) Postdoctoral Position – Intestinal Immunity (The University of Chicago) Postdoctoral Associate – Intestinal Immunology (The Scripps Research Institute) Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal (Surrozen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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