Intestinal Cell News Volume 6.12 | Apr 3 2020

TOP STORY

Paracrine Orchestration of Intestinal Tumorigenesis by a Mesenchymal Niche

By characterizing the heterogeneity of the intestinal mesenchyme using single-cell RNA-sequencing analysis, researchers identified a population of rare pericryptal Ptgs2-expressing fibroblasts that constitutively processed arachidonic acid into highly labile prostaglandin E₂. [Nature] Abstract

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Cloning of Ground-State Intestinal Stem Cells from Endoscopic Biopsy Samples

Scientists detail technology for the generation of ‘libraries’ of clonogenic cells from 1-mm-diamter endoscopic biopsy samples from the human gastrointestinal tract. [Nat Protoc] Abstract

A Novel Protein Encoded by circFNDC3B Inhibits Tumor Progression and EMT through Regulating Snail in Colon Cancer

CircFNDC3B was localized mostly in the cytoplasm, and was decreased in colon cancer cell lines and tissues. The patients with low circFNDC3B expression had a shorter OS than patients with high expression. [Mol Cancer] Full Article

CSN6-TRIM21 Axis Instigates Cancer Stemness during Tumorigenesis

Investigators showed that COP9 signalosome subunit 6 (CSN6) was critical for sphere formation and maintaining the growth of patient-derived organoids. [Br J Cancer] Abstract

Synthesis and Analysis of 64Cu-Labeled GE11-Modified Polymeric Micellar Nanoparticles for EGFR-Targeted Molecular Imaging in a Colorectal Cancer Model

In vitro fluorescence studies demonstrated significantly higher internalization of GE11-micelles into epidermal growth factor receptor (EGFR)-expressing HCT116 colon cancer cells versus EGFR-negative SW620 cells. [Mol Pharm] Abstract

Comprehensive Mapping of the Cell Response to E. coli Infection in Porcine Intestinal Epithelial Cells Pretreated with Exopolysaccharide Derived from Lactobacillus reuteri

Using transcriptomics, researchers comprehensively mapped the biological processes in porcine intestinal epithelial cells challenged with exopolysaccharide (EPS) derived from L. reuteri alone, enterotoxigenic Escherichia coli (ETEC) or ETEC after pretreatment with EPS. [Vet Res] Full Article

Sitagliptin Affects Gastric Cancer Cells Proliferation by Suppressing Melanoma‐Associated Antigen‐A3 Expression through Yes‐Associated Protein Inactivation

The authors showed that sitagliptin inhibited the proliferation of gastric cancer cells, and this inhibition was regulated by the Hippo pathway. Sitagliptin phosphorylated Yes‐associated protein (YAP) in a large tumor suppressor homolog‐dependent manner, thereby inhibiting YAP nuclear translocation, and promoted YAP cytoplasm retention. [Cancer Med] Full Article

Identification of the Combinatorial Effect of miRNA Family Regulatory Network in Different Growth Patterns of Gastric Cancer and Its Clinical Value

miR-29s were significantly correlated with gastric carcinogenesis and Ming’s classification. Biological function of miR-29s was most closely related to the pathway of ECM-receptor interaction. [Mol Ther Oncolytics] Abstract | Graphical Abstract

Stomatin-Like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in Colorectal Cancer

The authors report that high stomatin-like protein 2 expression was found in colorectal cancer tissues and was linked to tumor progression and tumor cell differentiation. [Mol Ther Oncolytics] Abstract | Graphical Abstract

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Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn’s Disease Patients

Given the advances driven by single-cell technologies, the authors reviewed the immune landscape and function of mononuclear phagocytes in inflamed non-lymphoid and lymphoid tissues of Crohn’s disease and ulcerative colitis patients. [Cells] Full Article

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

Merck Announces KEYTRUDA^® (Pembrolizumab) Significantly Improved Progression-Free Survival as First-Line Treatment for Advanced Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Colorectal Cancer

Merck announced that the Phase III KEYNOTE-177 trial evaluating first-line treatment of KEYTRUDA, Merck’s anti-PD-1 therapy, in patients with MSI-H or dMMR unresectable or metastatic colorectal cancer met one of its dual primary endpoints of progression-free survival. [Merck & Co., Inc.] Press Release

Fate Therapeutics Announces Worldwide Collaboration with Janssen for Novel iPSC-Derived Cell-Based Cancer Immunotherapies

Fate Therapeutics, Inc. announced a global collaboration and option agreement with Janssen Biotech, Inc. Under the multi-year collaboration agreement, Janssen will contribute proprietary antigen binding domains for up to four tumor-associated antigen targets. [Fate Therapeutics, Inc.] Press Release

Cull, Release or Bring Them Home: Coronavirus Crisis Forces Hard Decisions for Labs with Animals

As universities scale back operations and scientists observe stay-at-home orders, many are struggling to protect their research and the animals that power it. [Nature News] Editorial

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NEW PhD Student Position – Intestinal Homeostasis and Colorectal Cancer (Karolinska Institutet)

NEW Faculty Positions – Precision Medicine (Sun Yat-Sen University)

Postdoctoral Position – Defining the Transcriptional Landscape of the Intestinal Immunological Barrier (Karolinska Institutet)

Postdoctoral Position – Cancer Research (The Ohio State University)

Postdoctoral Fellow – Research Scientist (Medical College of Wisconsin)

Lab Manager – Intestinal Research (Howard Hughes Medical Institute)

Postdoctoral Fellow Position – Gene Editing and Genomic Evolution (Northwestern University)

Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Intestinal Immunity (The University of Chicago)

Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal (Surrozen)

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