Intestinal Cell News Volume 6.13 | Apr 17 2020

TOP STORY

Dendritic Cell-Derived Hepcidin Sequesters IRON from the Microbiota to Promote Mucosal Healing

The authors identified conventional dendritic cells as a source of hepcidin that was induced by microbial stimulation in mice, prominent in the inflamed intestine of humans, and essential for tissue repair. [Science] Abstract

(Ranked by impact factor of the journal)

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Scientists showed that intestinal Wnt inhibition by Lats deletion was yes-associated protein/transcriptional activator with PDZ-binding domain dependent but transcriptional enhanced associate domain (TEAD) independent. [Cell Stem Cell] Abstract | Graphical Abstract

Dietary Lipids Fuel GPX4-Restricted Enteritis Resembling Crohn’s Disease

Investigators report that small intestinal epithelial cells in Crohn’s disease exhibited impaired glutathione peroxidase 4 (GPX4) activity and signs of lipid peroxidation. [Nat Commun] Full Article

Resolvin E1 Is a Pro-Repair Molecule that Promotes Intestinal Epithelial Wound Healing

Exposure of intestinal epithelial cells to resolvin E1 promoted wound repair by increasing cellular proliferation and migration through activation of signaling pathways including CREB, mTOR, and Src-FAK. [Proc Natl Acad Sci USA] Abstract

IκBα Deficiency Imposes a Fetal Phenotype to Intestinal Stem Cells

IκBα-deficient intestinal cells produced morphologically aberrant organoids carrying a PRC2‐dependent fetal‐like transcriptional signature. [EMBO Rep] Abstract | Graphical Abstract

ASPP1 Deficiency Promotes Epithelial-Mesenchymal Transition, Invasion and Metastasis in Colorectal Cancer

Researchers report that loss of apoptosis-stimulating protein of p53 (ASPP)1 was capable of enhancing migration and invasion in colorectal cancer , both in vivo and in vitro. [Cell Death Dis] Full Article

A Tumor-Specific Modulation of Heterogeneous Ribonucleoprotein A0 Promotes Excessive Mitosis and Growth in Colorectal Cancer Cells

The downregulation assay of 20 representative heterogeneous ribonucleoproteins (hnRNPs), a major family of RNA-binding proteins, in colorectal cancer cells revealed that hnRNPA0 was a strong regulator of cancer cell growth. [Cell Death Dis] Full Article

Recurrence-Associated Long Non-Coding RNA LNAPPCC Facilitates Colon Cancer Progression via Forming Positive Feedback Loop with PCDH7

LNAPPCC promoted colon cancer cell proliferation, migration, and in vivo xenograft growth and liver metastasis. [Mol Ther Nucleic Acids] Abstract | Full Article | Graphical Abstract

Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem Cells

Scientists examined which colorectal cancer (CRC) tumors were more likely to generate organoids and benefit from ex vivo organoid drug testing. Long-term organoid cultures from 22 out of 40 CRC tumor specimens were established. [Cancers] Full Article

Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway

A series of amide anthraquinone derivatives were structurally modified and the resulting antitumor activities were evaluated. The compounds showed potent anti-proliferative activities against eight human cancer cell lines, with no noticeable cytotoxicity towards normal cells. [Molecules] Full Article

A Tryptophan Metabolite, 8-Hydroxyquinaldic Acid, Exerts Antiproliferative and Anti-Migratory Effects on Colorectal Cancer Cells

Researchers revealed that 8-hydroxyquinaldic acid inhibited not only proliferation and mitochondrial activity in colon cancer HT-29 and LS-180 cells, but it also decreased DNA synthesis up to 90.9% for HT-29 cells and 76.1% for LS-180 cells. [Molecules] Full Article

miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting capn2 in Colorectal Cancer

miR-124 inhibited tumorigenesis and promoted overall survival of mice bearing xenograft tumors, especially upon oxaliplatin treatment. miR-124 also promoted oxaliplatin-induced apoptosis and restrained CAPN2 protein expression in xenograft tumors. [Mol Ther Oncolytics] Abstract | Full Article | Graphical Abstract

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Head-to-Head Trials in Inflammatory Bowel Disease: Past, Present and Future

The authors provide an overview of the past, current and future concepts in inflammatory bowel disease trial design, with a detailed focus on the role of comparative research and the challenges and pitfalls in undertaking and interpreting the results from such studies. [Nat Rev Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

QIAGEN Launches Therascreen BRAF Test as Companion Diagnostic to a BRAFTOVI^® (Encorafenib) Based Regimen in Metastatic Colorectal Cancer

QIAGEN N.V. announced launch of its novel therascreen^® BRAF V600E RGQ PCR Kit following FDA approval as a companion diagnostic to the BRAF inhibitor, BRAFTOVI^®, which the FDA has approved for use in combination with cetuximab for the treatment of adult patients with metastatic colorectal cancer with a BRAF V600E mutation, as detected by an FDA-approved test, after prior therapy. [QIAGEN N.V.] Press Release

Knight Therapeutics Announces Approval of IBSRELA^™ in Canada

Knight Therapeutics, Inc. announced that Health Canada has approved IBSRELA^™ for the treatment of irritable bowel syndrome with constipation in adults. [Knight Therapeutics, Inc. (GlobeNewswire, Inc.)] Press Release

How Research Funders Are Tackling Coronavirus Disruption

While science is crucial to the fight against COVID-19, researchers confined to their homes and unable to carry on with grant-funded work are becoming increasingly concerned about how the coronavirus pandemic will affect their funding. [Nature News] Editorial

‘Short-Sighted.’ Health Experts Decry Trump’s Freeze on US Funding for WHO as World Fights Pandemic

President Donald Trump said he will suspend US funding to the World Health Organization (WHO) pending a 60- to 90-day investigation into how the agency has handled the response to the COVID-19 pandemic. [ScienceInsider] Editorial

How Scientists Can Volunteer to Help Fight COVID-19

Around the world, bench scientists other than those actively studying the pandemic have largely been forced to scale back or even shut down their experiments out of COVID-19 precautions. But that doesn’t mean their skills and expertise can’t contribute to the worldwide effort to address the disease. [The Scientist] Editorial

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NEW Postdoctoral Researcher – Translational Cancer Research (Johannes Kepler University of Linz)

NEW PhD Student – Cancer (Danish Cancer Society Research Center)

PhD Student Position – Intestinal Homeostasis and Colorectal Cancer (Karolinska Institutet)

Faculty Positions – Precision Medicine (Sun Yat-Sen University)

Postdoctoral Position – Defining the Transcriptional Landscape of the Intestinal Immunological Barrier (Karolinska Institutet)

Postdoctoral Position – Cancer Research (The Ohio State University)

Postdoctoral Fellow – Research Scientist (Medical College of Wisconsin)

Lab Manager – Intestinal Research (Howard Hughes Medical Institute)

Postdoctoral Fellow Position – Gene Editing and Genomic Evolution (Northwestern University)

Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal (Surrozen)

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