Intestinal Cell News 6.15 May 1, 2020 | |
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TOP STORYScientists identified TGFBR2 as the most prevalent tumor suppressor gene, followed by known and previously uncharacterized mediators of colorectal cancer growth. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators report the discovery and pharmacological characterization of AZD3229, a potent and selective small-molecule inhibitor of KIT and platelet-derived growth factor α (PDGFRα) designed to inhibit a broad range of primary and imatinib-resistant secondary mutations seen in gastrointestinal stromal tumors. [Sci Transl Med] Abstract Long Non-Coding RNA RAMS11 Promotes Metastatic Colorectal Cancer Progression A FDA-approved drug high-throughput viability assay showed that elevated RNAs associated with metastasis (RAMS)11 expression increased resistance to topoisomerase inhibitors. Subsequent experiments demonstrated RAMS11-dependent recruitment of chromobox protein 4 transcriptionally activated topoisomerase II alpha. [Nat Commun] Full Article Astrovirus Infects Actively Secreting Goblet Cells and Alters the Gut Mucus Barrier Using an in vivo model, the authors report that murine astrovirus preferentially infected actively secreting small intestinal goblet cells, specialized epithelial cells that maintain the mucus barrier. [Nat Commun] Full Article Drosophila as a Model for Studying Cystic Fibrosis Pathophysiology of the Gastrointestinal System Investigators showed that knockdown of Dmelcystic fibrosis (CF) transmembrane conductance regulator (CFTR) in the adult intestine disrupted osmotic homeostasis and displayed CF-like phenotypes that led to intestinal stem cell hyperplasia. [Proc Natl Acad Sci USA] Abstract Researchers demonstrated that cooperative recruitment of PC9 to the apoptosome, based on existing PC9-apoptosome interaction data, was important for efficient formation of PC9 homodimers, autocatalytic cleavage and dual regulation by XIAP and the molecular timer across biologically relevant PC9 and APAF1 concentrations. [Cell Death Differ] Full Article Scientists showed that ribosome biogenesis dysfunction strongly alleviated Wnt-driven tumor initiation by restoring cell cycle exit and differentiation in Apc-deficient progenitors. [Cell Death Differ] Full Article Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction Investigators found that aging altered epithelial immunity, metabolism, and cell proliferation and was accompanied by region-dependent skewing in the cellular composition of the epithelium. [Cell Rep] Full Article | Graphical Abstract Knockdown of BECN1 increased the phosphorylation of STAT3 and activated the STAT3 signaling pathway in colorectal cancer cells. [Cell Death Dis] Full Article Stearoyl-CoA desaturase-1 (SCD1) was found to increase the population of gastric cancer stem cells (GCSCs), whereas its suppression by an SCD1 inhibitor or knockdown by siRNA attenuated the stemness of GCSCs, including chemotherapy resistance and sphere-forming ability. [Br J Cancer] Abstract Scientists report a novel function of B-cell lymphoma 3 (Bcl-3) in maintaining colorectal cancer stem cell homeostasis by activating Wnt/β-catenin signaling. [Signal Transduct Target Ther] Full Article Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
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REVIEWSA deep understanding of nanomaterial (NM)-induced location-oriented effects (LOE) will facilitate the design of safer NMs and the development of more efficient nanomedicine for intestine-related diseases. Recent progress in this field is reviewed in order to better understand the LOE of nanomaterials. [Small] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSClinical Genomics announced key business updates related to Trident, the company’s first-line colorectal cancer screening blood test program, and its strategic alliance with Quest Diagnostic. [Clinical Genomics (GlobeNewswire, Inc.)] Press Release Pierre Fabre announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion recommending approval of the indication of BRAFTOVI® in combination with cetuximab for the treatment of adult patients with BRAFV600E-mutant metastatic colorectal cancer who have received prior systemic therapy. [Pierre Fabre (Business Wire, Inc.)] Press Release | |
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POLICY NEWSAs COVID-19 Forces Conferences Online, Scientists Discover Upsides of Virtual Format As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunities- for reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. [ScienceInsider] Editorial The Pandemic’s Effects on Recruiting International STEM Trainees Pandemic-related concerns that have arisen for science trainees-shuttered labs, research and education delays, anxiety—are applicable across the board. But international graduate students and postdocs face a suite of unique challenges that raise uncertainty about recruiting and supporting this critical group of researchers in the future. [The Scientist] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Group Leader – Cancer Biology (Northwestern University) Research Technician – Cancer (Oklahoma Medical Research Foundation) Postdoctoral Researcher – Translational Cancer Research (Johannes Kepler University of Linz) PhD Student – Cancer (Danish Cancer Society Research Center) Faculty Positions – Precision Medicine (Sun Yat-Sen University) Postdoctoral Position – Cancer Research (The Ohio State University) Postdoctoral Fellow – Research Scientist (Medical College of Wisconsin) Lab Manager – Intestinal Research (Howard Hughes Medical Institute) Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal (Surrozen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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