Intestinal Cell News 6.18 May 22, 2020 | |
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TOP STORYIn an analysis of intestinal epithelial cell (IEC) lines and colonoids derived from creatine transporter solute carrier family 6 member 8 (CRT)-knockout mice, scientists found that CRT regulated energy balance in IECs, and thereby epithelial integrity and barrier function. [Gastroenterology] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that TNFAIP8 was a regulator of intestinal homeostasis that was vital for proper regeneration. TIPE0 functioned through inhibiting basal Akt activation by the commensal microbiota via modulating membrane phospholipid abundance. [Nat Commun] Full Article Gasdermin D in Macrophages Restrains Colitis by Controlling cGAS-Mediated Inflammation Gasdermin D deficiency in macrophages, but not epithelial cells, was sufficient to drive this exacerbated experimental colitis. [Sci Adv] Full Article The authors addressed the prognostic value of tumor-associated macrophages (TAMs) using a total of 232 colorectal cancer patient tissue samples and investigated the mechanisms underlying TAM-related colon cancer progression with respect to PI3Kγ regulation using in vitro, in vivo, and ex vivo approaches. [Exp Mol Med] Full Article Expression of miR-21 was significantly up-regulated in exosomes of colon cancer cells, compared to the normal human colon epithelial cells. Treatment of colon cancer cells with isolated exosomes or miR-21 led to an increased expression of genes involved in cell proliferation, invasion and extracellular matrix formation. [Sci Rep] Full Article Characterization of Radioresistant Epithelial Stem Cell Heterogeneity in the Damaged Mouse Intestine Using lineage tracing, the authors found that Lgr5-expressing cell derivatives contained radioresistant intestinal stem cells crucial for epithelial regeneration in the damaged intestine after irradiation. [Sci Rep] Full Article DANCR was highly-expressed in colon cancer (CC) tissues and cell lines, and higher levels of DANCR were linked with worse prognosis and less survival time of CC patients. [BMC Cancer] Full Article Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells The authors investigated whether β-hydroxybutyrate supplementation exerted beneficial effects on age-related changes in intestinal stem cells that were derived from the Drosophila midgut. [Int J Mol Sci] Full Article IDO1+ Paneth Cells Promote Immune Escape of Colorectal Cancer Investigators discovered indoleamine-2,3-dioxygenase-1 (IDO1)+ Paneth cells in the stem cell niche of intestinal crypts and tumors, which promoted immune escape of colorectal cancer. [Commun Biol] Full Article The authors report that robust sialylated Lewis glycan expression was induced in colonic mucosa from individuals with ulcerative colitis and Crohn’s disease as well as in colonic epithelium of mice with DSS colitis. [JCI Insight] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Pulmonary Cell News & ESC & iPSC News. | |
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REVIEWSScientists discuss the current findings on the role of desmoglein 2 as a novel promising target to prevent loss of intestinal barrier function in inflammatory bowel disease patients. [Acta Physiol (Oxf)] Full Article Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWSENHERTU® Granted Orphan Drug Designation in the US for Gastric Cancer Daiichi Sankyo Company, Limited has been granted Orphan Drug Designation in the US for the treatment of patients with gastric cancer, including gastroesophageal junction cancer. [Daiichi Sankyo Company, Limited] Press Release | |
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POLICY NEWSWill Trump White House Tear Down Journal Paywalls? Many Anxiously Await a Decision Scientific publishers, universities, librarians, and open-access advocates are waiting anxiously to see whether the Trump administration will end a long-standing policy and require that every scholarly article produced with US funding be made immediately free to all. [ScienceInsider] Editorial Are Women Publishing Less during the Pandemic? Here’s What the Data Say Early analyses suggest that female academics are posting fewer preprints and starting fewer research projects than their male peers. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Intestinal Immunological Barrier (Karolinska Institutet) NEW Research Scientist – Oncology (Gilead Sciences, Inc.) Postdoctoral Position – Gastrointestinal Disorders (KU Leuven) Postdoctoral Position – Colorectal Carcinogenesis (Universitätsklinikum Erlangen) Postdoctoral Fellow – Cancer Biology (Augusta University) Group Leader – Cancer Biology (Northwestern University) Faculty Positions – Precision Medicine (Sun Yat-Sen University) Lab Manager – Intestinal Research (Howard Hughes Medical Institute) Research Scientist – In Vivo Research on Wnt Signaling in Self-Renewal (Surrozen) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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