| Vol. 6.23 – 26 June, 2020 |
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| Researchers uncovered a key survival signal in colorectal cancer through convergent repression of Bim expression by distinct spermine synthase and MYC-mediated signaling pathways. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that upon Adherent-invasive E. coli (AIEC) infection, intestinal epithelial cells (IECs) secreted exosomes that could transfer specific miRNAs to recipient IECs, inhibiting autophagy-mediated clearance of intracellular AIEC. [Gut Microbes] |
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| Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. [Cell Death & Disease] |
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| Researchers verified enalapril, a clinically widely used antihypertensive and anti-heart failure drug, as a chemosensitizer that improved sensitivity of colorectal cancer cells to 5-Fluorouracil. [Cell Death & Disease] |
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| Investigators revealed that Wnt activity triggered the expression of the gene, LARGE2, which in turn mediated the laminin- adhesive O-glycosylation of α-DG. They found abnormally increased cellular adhesion to laminin during Wnt-driven cancer progression. [Cell Communication and Signaling] |
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| The authors demonstrated that the artificial sweeteners sucralose, aspartame, and saccharin exerted a range of negative effects on the intestinal epithelium through the sweet taste receptor T1R3. [Nutrients] |
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| Researchers revealed CD47 as a negative regulator in intestinal epithelial cell renewal during colitis through downregulating OSKM transcriptional factors. [Scientific Reports] |
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| Scientists suggested that the pre-mRNA processing factor 4B kinase domain was responsible for promoting drug resistance to curcumin by inducing EMT. [Molecules and Cells] |
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| Using chemically induced and spontaneous mouse colorectal cancer (CRC) models colonized by colibactin-producing Escherichia coli, scientists established the role of microbiota in mediating the antitumorigenic effect of anti–tumor necrosis factor therapy. [Nature Cancer] |
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| The authors review the current state of research of how metabolism and ageing control intestinal stem cell function and epithelial homeostasis. [EMBO Reports] |
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| Natera, Inc. announced that enrollment has begun in the CIRCULATE-Japan and BESPOKE CRC trials, with both studies experiencing strong interest from centers across Japan and the U.S. The studies will measure clinical outcomes of Signatera molecular residual disease testing in resectable stages II-IV colorectal cancer. [Natera] |
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| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behaviour, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs. [Nature News] |
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| Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle. [ScienceInsider] |
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| 1/21/2021 – 1/23/2021 Las Vegas, Nevada, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| KU Leuven – Leuven, Belgium |
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| Howard Hughes Medical Institute – Chevy Chase, Maryland, United States |
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| Gilead Sciences, Inc. – Seattle, Washington, United States |
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| GSK – Collegeville, Pennsylvania, United States |
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