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| In mice with dextran sodium sulfate or T cell-induced colitis, loss of histocompatibility complex class II (MHCII) from Intestinal epithelial cells reduced but did not eliminate mucosal inflammation. However, in mice with C rodentium-induced colitis, loss of MHCII reduced bacterial clearance by decreasing binding of IgA to commensal and pathogenic bacteria. [Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report a nonpyroptotic role of full-length Gasdermin D in guiding the release of IL-1β–containing small extracellular vesicles from intestinal epithelial cells . [Journal of Clinical Investigation] |
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| Investigators defined a C-C motif chemokine ligand 7-CCR1-SRY-box transcription factor positive feedback loop that played a pivotal role in gastric cancer metastasis [Oncogene] |
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| Results demonstrated that CDK5 regulatory subunit-associated protein 3 was suppressed by extracellular-related kinase signalling and negatively regulated the self-renewal and epithelial-to-mesenchymal transition of gastric cancer stem-like cells. [British Journal of Cancer] |
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| Scientists showed vulnerability of KRAS-mutant cells towards suppression of minichromosome maintenance complex component 7 and suggested that inhibiting DNA replication licensing might be a viable strategy to target KRAS-mutant cancers. [Cell Death & Disease] |
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| Researchers found that microRNA‐500a‐3p was highly expressed in cisplatin resistant gastric cancer cells and their secreted exosomes than that in the corresponding parental cells. [Journal of Cellular and Molecular Medicine] |
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| Scientists presented an alternate method to culture individually selected cells in relative isolation from the rest of the population under physiologically relevant matrix conditions. Using examples of breast and colorectal cancers, scientists showed that individual cells evolved into tumors or aspects of tumors displaying different characteristics of the initial cancer type and aggressiveness. [Scientific Reports] |
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| The novel NRAS mutant E132K, identified in three tumor samples from Filipino young-onset, sporadic colorectal cancer patients, was investigated for its effects on different cancer hallmarks, alongside the NRAS canonical mutants G12D and Q61K which were yet poorly characterized in the context of colorectal cancer. [Scientific Reports] |
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| The authors give an update on International Tumour Budding Consensus Conference validation studies in the context of colorectal cancer and the clinical implications of tumour budding throughout the upper gastrointestinal and pancreatico-biliary tract. [British Journal of Cancer] |
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| Celltrion Healthcare announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended expanding the existing marketing authorisation for the subcutaneous formulation of Remsima® in an additional five indications: for the treatment of patients with ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriatic arthritis and psoriasis. [Celltrion] |
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| The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map. [ScienceInsider] |
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| Academics in Hong Kong are facing new worries after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom. [ScienceInsider] |
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| University of Virginia – Charlottesville, Virginia, United States |
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| KU Leuven – Leuven, Belgium |
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| Howard Hughes Medical Institute – Chevy Chase, Maryland, United States |
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| Gilead Sciences, Inc. – Seattle, Washington, United States |
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| GSK – Collegeville, Pennsylvania, United States |
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