 | | Vol. 6.25 – 10 July, 2020 |
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| Scientists report that steroid signaling in Drosophila from ovaries to gut promoted growth of the intestine specifically in mated females, and enhanced their reproductive output.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| This study reports that alpha‐lipoic acid reversed age‐associated intestinal stem cell dysfunction by promoting the activation of the endocytosis–autophagy network, which was decreased in aged intestinal stem cells.
[EMBO Reports] |
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| The authors supported, within a biomimetic 3D, in vitro framework, the direct role of cancer-associated fibroblasts in promoting cancer invasion, and their key function in driving vasculogenesis and angiogenesis.
[British Journal of Cancer] |
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| To assess the safety of and protection conferred by Nissle, researchers modeled infection in stem cell-derived human intestinal organoids.
[American Society for Microbiology] |
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| Researchers demonstrated that post-ionizing radiation overexpression of TIGAR, a critical downstream target of c-MYC in mouse intestine, mounted a hyperplastic response in Bmi1-creERT+ reserve ISCs, and thus rescued mice from lethal ionizing radiation exposure.
[Cell Death & Disease] |
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| This study revealed an acetylation-dependent regulatory mechanism that governed the tumor-suppressive function of HINT1.
[Experimental and Molecular Medicine] |
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| The authors report that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation.
[Oncogenesis] |
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| The results from this study demonstrated that A. simplex induced an early and reversible alteration of integrity and permeability of caco-2 cell monolayer and that an underlying mechanism of this effect would have involved the oxidative stress and disruption of epithelial tight junctions.
[PLoS Neglected Tropical Diseases] |
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| Investigators demonstrated essential roles of ubiquitin-specific protease 25 in experimental colitis, bacterial infections and colon cancer.
[Nature Cancer] |
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| The authors provide an update on the literature to understand how genetics, diet, and the gut microbiota influence the crosstalk between immune and non-immune cells resulting in inflammation observed in multiple colonic pathologies.
[International Journal of Molecular Sciences] |
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| UCB and Ferring Pharmaceuticals Inc. announced they have entered into a co-promotion agreement to commercialize the prefilled syringe formulation of CIMZIA® in the United States, specifically for the treatment of Crohn’s disease.
[UCB] |
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| International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT] |
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| July 16 – July 17
Virtual |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | KU Leuven – Leuven, Belgium |
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| | Howard Hughes Medical Institute – Chevy Chase, Maryland, United States |
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| | Gilead Sciences, Inc. – Seattle, Washington, United States |
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| | GSK – Collegeville, Pennsylvania, United States |
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