 | | Vol. 6.26 – 17 July, 2020 |
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| Scientists studied the pathways that regulate activating transcription factor 6 and its role for inflammation in intestinal epithelial cells.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In addition to its known microbicidal action, cathelicidin had a unique pathogen-sensing role, facilitating LPS-mediated intestinal responses, including the production of CXCL8/CXCL1 that would contribute to an integrated tissue response to recruit neutrophils during colitis.
[Gut Microbes] |
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| Researchers investigated whether itraconazole induced autophagy-mediated cell death of colon cancer cells through the Hedgehog signaling pathway.
[Cell Death & Disease] |
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| Investigators unraveled the possible involvement of long noncoding RNAs and microRNAs regulating pleckstrin-homology-domain leucine-rich-repeat protein phosphatases (PHLPP2 ) in colon cancer.
[Aging] |
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| Scientists investigated the effects of AKT-mediated miR-125b-5p alteration on metabolic changes and examined how these molecules enhanced migration and induced drug resistance in colon cancer cells.
[Carcinogenesis] |
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| By harnessing cancer stem cell specific cytotoxic function of salinomycin, the authors discovered a critical role of epigenetic modulator EZH2 in regulating the expression of death receptors in colon cancer stem cells.
[Epigenetics] |
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| Researchers demonstrated that inhibition of AXL signaling with the small molecule inhibitor BGB324 abrogated both matrix-stiffness and transforming growth factor beta–induced fibrogenesis in human colonic myofibroblasts.
[Inflammatory Bowel Diseases] |
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| By using Wnt/β-catenin pathway epistasis experiment, scientists showed that piperine inhibited the canonical Wnt pathway induced by overexpression of β-catenin, β-catenin S33A or dnTCF4 VP16, while also suppressing β-catenin nuclear localization in a HCT116 cell line.
[Scientific Reports] |
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| Investigators explored the effects of alginate oligosaccharides on the integrity and migration of small intestine cells using swine intestinal epithelial IPEC-J2 cells.
[Life Sciences] |
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| The authors discuss the underlying molecular and cellular underpinnings that control programmed cell death in intestinal epithelial cells, which emerge during intestinal diseases.
[Nature Reviews Gastroenterology & Hepatology] |
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| Mylan N.V. and Fujifilm Kyowa Kirin Biologics Co., Ltd. announced that the FDA has approved Hulio® for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult crohn’s disease, ulcerative colitis and plaque psoriasis, in both prefilled syringe and auto-injector presentations.
[Mylan] |
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| Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
[Science Insider] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
[Nature News] |
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| August 27 – August 29
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | City of Hope – Monrovia, California, United States |
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| | Surrozen, Inc. – South San Francisco, California, United States |
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| | GSK – Collegeville, Pennsylvania, United States |
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| | Howard Hughes Medical Institute – New York, New York, United States |
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