Intestinal Cell News Volume 6.27 | July 24 2020

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    2020-07-24 | ICN 6.27


    Intestinal Cell News by STEMCELL Technologies
    Vol. 6.27 – 24 July, 2020
    TOP STORY

    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

    Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Copper Bioavailability Is a KRAS-Specific Vulnerability in Colorectal Cancer

    ATP7A regulated the intracellular copper levels and tumor growth in KRAS-transformed cells. Investigators demonstrated that inhibiting copper supply was an attractive therapeutic option for KRAS-mutant cells.
    [Nature Communications]

    Full Article

    LASP1 Interacts with N-WASP to Activate the Arp2/3 Complex and Facilitate Colorectal Cancer Metastasis by Increasing Tumour Budding and Worsening the Pattern of Invasion

    Investigators suggested a new mechanism for LIM and SH3 protein 1(LASP1)-mediated colorectal cancer metastasis determined by exploring LASP1-interacting proteins, and identified N–Wiskott–Aldrich syndrome protein as a potential therapeutic target for colorectal cancer.
    [Oncogene]

    Abstract

    Circular RNA circCTNNA1 Promotes Colorectal Cancer Progression by Sponging miR-149-5p and Regulating FOXM1 Expression

    circCTNNA1 promoted colon cancer cell proliferation, migration, and invasion in vitro and in vivo. It could serve as a competing endogenous RNA of miR-149-5p to counteract the suppressive effect of miR-149-5p on downstream target Forkhead Box M1.
    [Cell Death & Disease]

    Full Article

    Upregulation of OSBPL3 by HIF1A Promotes Colorectal Cancer Progression through Activation of RAS Signaling Pathway

    Scientists investigated the role of OSBPL3 in colorectal cancer and found that its expression was significantly higher in colorectal cancer tissues than that in normal tissues.
    [Cell Death & Disease]

    Full Article

    The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer

    The authors found that cells depleted of Ajuba were less proliferative, more sensitive to irradiation, migrated less and less efficient in colony formation. In addition, loss of Ajuba expression decreased the tumor burden in a murine model of colorectal metastasis to the liver.
    [Cancers]

    Full Article

    N-Myristoyltransferase-1 Is Necessary for Lysosomal Degradation and mTORC1 Activation in Cancer Cells

    Researchers used genetic and pharmacological inhibition of N-myristoyltransferase-1 (NMT1) to further dissect the role of this enzyme in cancer, and found an unexpected essential role for NMT1 at promoting lysosomal metabolic functions.
    [Scientific Reports]

    Full Article

    PI3K-Targeting Strategy Using Alpelisib to Enhance the Antitumor Effect of Paclitaxel in Human Gastric Cancer

    The authors investigated the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of gastric cancer. The combined effects of alpelisib and paclitaxel on gastric cancer was also evaluated.
    [Scientific Reports]

    Full Article

    Pevonedistat (MLN4924): Mechanism of Cell Death Induction and Therapeutic Potential in Colorectal Cancer

    Investigators identified p53 as an important mediator of the apoptotic response to pevonedistat. They also found roles for the extrinsic and intrinsic apoptotic pathways in mediating the apoptotic effects of pevonedistat in colorectal cancer cells, as well as a role for BID, which modulates a cross-talk between these pathways.
    [Cell Death Discovery]

    Full Article

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    REVIEWS

    Nitric Oxide (NO) and NO Synthases (NOS)-Based Targeted Therapy for Colon Cancer

    The authors summarize the multifaceted mechanisms of NO-mediated networks in several hallmarks of colorectal cancer. They review the clinical manifestation and limitations of NO donors and NOS inhibitors in clinical trials and discuss the possible directions of NO/NOS therapies in the immediate future.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    LintonPharm Announces Authorization From China Health Authority to Proceed with a Global Phase III Trial Evaluating Catumaxomab in Advanced Gastric Cancer

    LintonPharm Co. Ltd. announced that China National Medical Products Administration authorized the company to proceed with a Phase III trial for catumaxomab in patients with peritoneal carcinomatosis, a form of advanced gastric cancer that has spread to the tissue that lines the abdominal cavity.
    [LintonPharm Co. Ltd (BusinessWire, Inc.)]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

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