| Vol. 6.27 – 24 July, 2020 |
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| Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| ATP7A regulated the intracellular copper levels and tumor growth in KRAS-transformed cells. Investigators demonstrated that inhibiting copper supply was an attractive therapeutic option for KRAS-mutant cells. [Nature Communications] |
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| Investigators suggested a new mechanism for LIM and SH3 protein 1(LASP1)-mediated colorectal cancer metastasis determined by exploring LASP1-interacting proteins, and identified N–Wiskott–Aldrich syndrome protein as a potential therapeutic target for colorectal cancer. [Oncogene] |
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| circCTNNA1 promoted colon cancer cell proliferation, migration, and invasion in vitro and in vivo. It could serve as a competing endogenous RNA of miR-149-5p to counteract the suppressive effect of miR-149-5p on downstream target Forkhead Box M1. [Cell Death & Disease] |
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| Scientists investigated the role of OSBPL3 in colorectal cancer and found that its expression was significantly higher in colorectal cancer tissues than that in normal tissues. [Cell Death & Disease] |
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| The authors found that cells depleted of Ajuba were less proliferative, more sensitive to irradiation, migrated less and less efficient in colony formation. In addition, loss of Ajuba expression decreased the tumor burden in a murine model of colorectal metastasis to the liver. [Cancers] |
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| Researchers used genetic and pharmacological inhibition of N-myristoyltransferase-1 (NMT1) to further dissect the role of this enzyme in cancer, and found an unexpected essential role for NMT1 at promoting lysosomal metabolic functions. [Scientific Reports] |
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| The authors investigated the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of gastric cancer. The combined effects of alpelisib and paclitaxel on gastric cancer was also evaluated. [Scientific Reports] |
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| Investigators identified p53 as an important mediator of the apoptotic response to pevonedistat. They also found roles for the extrinsic and intrinsic apoptotic pathways in mediating the apoptotic effects of pevonedistat in colorectal cancer cells, as well as a role for BID, which modulates a cross-talk between these pathways. [Cell Death Discovery] |
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| The authors summarize the multifaceted mechanisms of NO-mediated networks in several hallmarks of colorectal cancer. They review the clinical manifestation and limitations of NO donors and NOS inhibitors in clinical trials and discuss the possible directions of NO/NOS therapies in the immediate future. [Cancers] |
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| LintonPharm Co. Ltd. announced that China National Medical Products Administration authorized the company to proceed with a Phase III trial for catumaxomab in patients with peritoneal carcinomatosis, a form of advanced gastric cancer that has spread to the tissue that lines the abdominal cavity. [LintonPharm Co. Ltd (BusinessWire, Inc.)] |
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| The French government unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years. [ScienceInsider] |
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| September 10 – September 11 Virtual |
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| Ohio State University, Wexner Medical Center – Columbus, Ohio, United States |
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| Surrozen, Inc. – South San Francisco, California, United States |
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| City of Hope – Monrovia, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| GSK – Collegeville, Pennsylvania, United States |
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