Intestinal Cell News Volume 6.30 | Aug 14 2020

May 12, 2022

2020-08-14 | ICN 6.30

Intestinal Cell News by STEMCELL Technologies

Vol. 6.30 – 14 August, 2020

TOP STORY

H₂S‐Scavenged
and Activated Iron Oxide‐Hydroxide Nanospindles for MRI‐Guided Photothermal Therapy and Ferroptosis in Colon Cancer

A biocompatible fusiform iron oxide‐hydroxide nanospindles nanosystem for magnetic resonance imaging (MRI), ferroptosis, and H₂S based cascade reaction‐enhanced combinational colon cancer treatment was developed.
[Small]

Abstract

Watch 'collaborating to accelerate COVID-19 research'

PUBLICATIONSRanked by the impact factor of the journal

Ecdysone Steroid Hormone Remote Controls Intestinal Stem Cell Fate Decisions via the PPARγ
-Homolog Eip75B in Drosophila

The PPARγ-homologue Ecdysone-induced-protein-75B (Eip75B) drove intestinal stem cell daughter cells towards absorptive enterocyte lineage ensuring epithelial growth.
[eLife]

Abstract

BRAF^V600E
Drives Dedifferentiation in Small Intestinal and Colonic Organoids and Cooperates with Mutant p53 and Apc Loss in Transformation

BRAF^V600E induced a fetal-like dedifferentiation transcriptional program in colonic organoids, which resembled human BRAF^V600E-driven colorectal cancer.
[Oncogene]

Full Article

FBX8 Promotes Metastatic Dormancy of Colorectal Cancer in Liver

Scientists revealed a novel mechanism of FBX8 in regulating tumor metastatic dormancy in liver and provided new strategies for the treatment of colorectal cancer metastasis.
[Cell Death & Disease]

Full Article

Intestinal
Vitamin D Receptor Signaling Ameliorates Dextran Sulfate Sodium‐Induced Colitis by Suppressing Necroptosis of Intestinal Epithelial Cells

Researchers explored the effect of intestinal vitamin D signaling on necroptosis and the underlying mechanism in colitis.
[FASEB Journal]

Full Article

Regulation of Colonic Epithelial Cell Homeostasis by mTORC1

Scientists showed that ablation of tuberous sclerosis complex 2, a negative regulator of mammalian target of rapamycin complex 1 (mTORC1), specifically in intestinal epithelial cells of mice resulted in increased activity of mTORC1 of, as well as increased proliferative activity of, colonic epithelial cells.
[Scientific Reports]

Full Article

Modulation
of Glycosyltransferase ST6Gal-I in Gastric Cancer-Derived Organoids Disrupts Homeostatic Epithelial Cell Turnover

To determine the functional impact of increased ST6Gal-I, researchers generated human gastric antral organoids from epithelial stem cells and differentiated epithelial monolayers from gastric organoids.
[Journal of Biological Chemistry]

Full Article

Evaluation
of Isoindole Derivatives: Antioxidant Potential and Cytotoxicity in the HT‐29 Colon Cancer Cells

Scientists evaluated the antioxidant and cytotoxic potential of four synthesized isoindoline derivatives. HT‐29 cells exposed to 10, 50, 100, and 200 µM doses of each derivative were incubated for 24 and 48 hours, respectively.
[Archiv Der Pharmazie]

Abstract

Lipid
Composition of Liposomal Membrane Largely Affects Its Transport and Uptake through Small Intestinal Epithelial Cell Models

The authors investigated the transport and uptake of liposomes composed of docosahexaenoic acid‐enriched phosphatidylcholine, phosphatidylserine, and sulfoquinovosyl diacylglycerol derived from marine products on multilamellar vesicles in small intestinal epithelial cell models.
[Lipids]

Abstract

Tumors Are 3D. Your 2D Model May Not Give You All The Answers. Learn More.

REVIEWS

Plasticity
of Paneth Cells and Their Ability to Regulate Intestinal Stem Cells

The authors summarize key signaling pathways that affect Paneth cell (PC) differentiation and mutual effect with intestinal stem cells. In this review, they introduce the diverse functions of PCs in the intestine.
[Stem Cell Research & Therapy]

Full Article

INDUSTRY AND POLICY NEWS

Genentech
Provides Update on Phase III Studies of Etrolizumab in People with Moderately to Severely Active Ulcerative Colitis

Genentech announced topline results from its Phase III study program evaluating the investigational medicine etrolizumab in people with moderately to severely active ulcerative colitis.
[Genentech]

Press Release

CheckMate
-577, a Phase III Trial Evaluating Opdivo (Nivolumab) as Adjuvant Therapy for Patients with Resected Esophageal or Gastroesophageal Junction Cancer, Meets Primary Endpoint of Disease-Free Survival

Bristol Myers Squibb announced the Phase III CheckMate -577 trial evaluating Opdivo as an adjuvant therapy for patients with resected esophageal or gastroesophageal junction cancer met its primary endpoint of disease-free survival at a pre-specified interim analysis.
[Bristol Myers Squibb]

Press Release

CheckMate
-649, a Phase III Trial Evaluating Opdivo (Nivolumab) Plus Chemotherapy vs. Chemotherapy, Meets Primary Endpoints Demonstrating Superior Overall Survival and Progression-Free Survival in First-Line Treatment of Gastric and Esophageal Cancers

Bristol Myers Squibb announced that CheckMate -649, a pivotal Phase III trial evaluating Opdivo plus chemotherapy compared to chemotherapy alone as a first-line treatment for metastatic gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma, met both primary endpoints of overall survival at a pre-specified interim analysis and progression-free survival at final analysis in patients whose tumors express PD-L1 with a combined positive score ≥ 5.
[Bristol Myers Squibb]

Press Release

FEATURED EVENT

H₂S‐Scavenged
and Activated Iron Oxide‐Hydroxide Nanospindles for MRI‐Guided Photothermal Therapy and Ferroptosis in Colon Cancer

Ecdysone Steroid Hormone Remote Controls Intestinal Stem Cell Fate Decisions via the PPARγ
-Homolog Eip75B in Drosophila

BRAF^V600E
Drives Dedifferentiation in Small Intestinal and Colonic Organoids and Cooperates with Mutant p53 and Apc Loss in Transformation

FBX8 Promotes Metastatic Dormancy of Colorectal Cancer in Liver

Intestinal
Vitamin D Receptor Signaling Ameliorates Dextran Sulfate Sodium‐Induced Colitis by Suppressing Necroptosis of Intestinal Epithelial Cells

Regulation of Colonic Epithelial Cell Homeostasis by mTORC1

Modulation
of Glycosyltransferase ST6Gal-I in Gastric Cancer-Derived Organoids Disrupts Homeostatic Epithelial Cell Turnover

Evaluation
of Isoindole Derivatives: Antioxidant Potential and Cytotoxicity in the HT‐29 Colon Cancer Cells

Lipid
Composition of Liposomal Membrane Largely Affects Its Transport and Uptake through Small Intestinal Epithelial Cell Models

Plasticity
of Paneth Cells and Their Ability to Regulate Intestinal Stem Cells

Genentech
Provides Update on Phase III Studies of Etrolizumab in People with Moderately to Severely Active Ulcerative Colitis

CheckMate
-577, a Phase III Trial Evaluating Opdivo (Nivolumab) as Adjuvant Therapy for Patients with Resected Esophageal or Gastroesophageal Junction Cancer, Meets Primary Endpoint of Disease-Free Survival

CheckMate
-649, a Phase III Trial Evaluating Opdivo (Nivolumab) Plus Chemotherapy vs. Chemotherapy, Meets Primary Endpoints Demonstrating Superior Overall Survival and Progression-Free Survival in First-Line Treatment of Gastric and Esophageal Cancers

The New York Stem Cell Foundation (NYSCF) Conference

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Director
– Surgical Oncology

Postdoctoral Research Associate – Tumor Microenvironment

Research
Associate – Lipid Metabolism

Post Doctoral Fellow – Digestive Diseases

Postdoctoral Associate – Colorectal Cancer

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