Intestinal Cell News Volume 6.32 | Aug 28 2020

    0
    17







    2020-08-28 | ICN 6.32


    Intestinal Cell News by STEMCELL Technologies
    Vol. 6.32 – 28 August, 2020
    TOP STORY

    Succinate
    Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

    Scientists performed single-cell RNA-sequencing, mass spectrometry, and microbiome profiling of intestinal tissues from wildtype and ATOH1-knockout mice, which have expansion of tuft cells, to study interactions between microbes and tuft cell populations.
    [Gastroenterology]

    Full Article


    Immunofluorescence image of adult stem cell-derived intestinal organoids.
    PUBLICATIONSRanked by the impact factor of the journal

    Infiltration
    by Interleukin-22 Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

    Exposure of colorectal cancer cells to interleukin -22 (IL-22) promoted the release of the neutrophil recruiting chemokines CXCL1, CXCL2 and CXCL3 and enhanced neutrophil migration in vitro. Combined survival analysis revealed that the favorable prognostic significance of IL-22 in colorectal cancer cells relied on the presence of neutrophils and was enhanced by T cell infiltration.
    [Cancer Immunology Research]

    Abstract

    4-Hydroxyacetophenone
    Modulates the Actomyosin Cytoskeleton to Reduce Metastasis

    Researchers showed that 4-hydroxyacetophenone inhibited colon cancer cell adhesion, invasion, and migration in vitro and reduced the metastatic burden in an in vivo model of colon cancer metastasis to the liver. Treatment with 4-HAP activated nonmuscle myosin-2C (NM2C) to alter actin organization, inhibiting the mechanical program of metastasis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    IGF-1R Inhibition Induces MEK Phosphorylation to Promote Survival in Colon Carcinomas

    Scientists discovered that prolonged treatment of colon cancer cells with insulin-like growth factor 1 receptor (IGF-1R) inhibitors stimulated p70 KDa ribosomal protein S6 kinase 1 (p70S6K1) activation, a well-known kinase signaling for cell survival. They also found that p70S6K1 activation by IGF-1R inhibition was independent of K-Ras and PIK3CA mutations that frequently occur in colon cancer.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Transcriptome
    Profiling Analysis Reveals That ATP6V0E2 Is Involved in the Lysosomal Activation by Anlotinib

    Through transcriptome sequencing, scientists found that anlotinib treatment upregulated ATPase H+ Transporting V0 Subunit E2 (ATP6V0E2) and other lysosome-related genes expression in human colon cancer.
    [Cell Death & Disease]

    Full Article

    Andrographis-Mediated
    Chemosensitization through Activation of Ferroptosis and Suppression of β-Catenin/Wnt-Signaling Pathways in Colorectal Cancer

    A genomewide expression analysis in cell lines led scientists to uncover that activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways were the key mediators for the anti-cancer and chemosensitizing effects of andrographis.
    [Carcinogenesis]

    Abstract

    Cholesterol
    25-Hydroxylase Protects against Experimental Colitis in Mice by Modulating Epithelial Gut Barrier Function

    Scientists revealed a protective role for 25-hydroxycholesterol in dextran sulfate sodium(DSS)-induced colitis and the ability of cholesterol 25-hydroxylase to maintain epithelial gut barrier function through ATF3 expression.
    [Scientific Reports]

    Full Article

    LncRNA
    SNHG16 Promotes Colorectal Cancer Cell Proliferation, Migration, and Epithelial–Mesenchymal Transition through miR-124-3p/MCP-1

    Knockdown of SNHG16 attenuated cell proliferation, migration, invasion, and EMT of colorectal cancer (CRC) cells. In contrast, miR-124-3p exerted the antitumor effects. Knockdown of miR-124-3p could reverse the effect of sh-SNHG16 on CRC cells. miR-124-3p could directly bind to SNHG16 or MCP-1. MCP-1 acted as a critical effector mediating the role of SNHG16/ miR-124-3p in CRC cells.
    [Gene Therapy]

    Abstract

    Cyclic
    Derivative of Morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a Mixed Agonist of Mop and Kop Opioid Receptors, Exerts Anti-Inflammatory and Anti-Tumor Activity in Colitis and Colitis-Associated Colorectal Cancer in Mice

    In a previous study, researchers demonstrated that stimulation of opioid receptors using P-317, a cyclic morphiceptin analog, resulted in the alleviation of acute colitis in mice. The current study assessed the effect of P-317 during colitis and colitis-associated colorectal cancer in mice.
    [European Journal of Pharmacology]

    Abstract


    On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now
    REVIEWS

    Intestinal Regeneration: Regulation by the Microenvironment

    Regeneration is influenced by the nutritional state, microbiome, and extracellular matrix. The authors review how all these components cooperate to restore epithelial homeostasis in the intestine after injury.
    [Developmental Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    Applied
    Molecular Transport Announces First Patient Dosed in Phase II Study of Oral AMT-101 in Ulcerative Colitis

    Applied Molecular Transport announced that the first patient has been dosed in a randomized, placebo-controlled, double-blind, multicenter Phase IIa study evaluating the efficacy and safety of oral AMT-101 in patients with moderate to severely active ulcerative colitis.
    [Applied Molecular Transport ]

    Press Release

    Cerecor
    Resumes Phase Ib Clinical Trial of CERC-002 for the Treatment of Severe Pediatric Onset Crohn’s Disease

    Cerecor, Inc. announced it has resumed the Phase Ib clinical study of CERC-002 in anti-TNF refractory adult crohn’s patients with the lifting of the moratorium on elective endoscopy resulting from the COVID-19 pandemic.
    [Cerecor, Inc. ]

    Press Release

    FEATURED EVENT

    Cancer Research & Oncology 2020

    October 7 – 8
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Gastric Cancer

    The University of Arizona – Tucson, Arizona, United States

    Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

    City of Hope – Monrovia, California, United States

    Postdoctoral Research Associate – Tumor Microenvironment

    USC Lawrence J. Ellison Institute for Transformative Medicine – West Los Angeles, California, United States

    Research
    Associate – Lipid Metabolism

    University of Kentucky – Lexington, Kentucky, United States

    Post Doctoral Fellow – Digestive Diseases

    Emory University – Atlanta, Georgia, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Intestinal Cell News
    Archives Contact Us
    Intestinal Cell News Twitter