| Vol. 6.32 – 28 August, 2020 |
| |
|
|
| Scientists performed single-cell RNA-sequencing, mass spectrometry, and microbiome profiling of intestinal tissues from wildtype and ATOH1-knockout mice, which have expansion of tuft cells, to study interactions between microbes and tuft cell populations. [Gastroenterology] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Exposure of colorectal cancer cells to interleukin -22 (IL-22) promoted the release of the neutrophil recruiting chemokines CXCL1, CXCL2 and CXCL3 and enhanced neutrophil migration in vitro. Combined survival analysis revealed that the favorable prognostic significance of IL-22 in colorectal cancer cells relied on the presence of neutrophils and was enhanced by T cell infiltration. [Cancer Immunology Research] |
|
|
|
| Researchers showed that 4-hydroxyacetophenone inhibited colon cancer cell adhesion, invasion, and migration in vitro and reduced the metastatic burden in an in vivo model of colon cancer metastasis to the liver. Treatment with 4-HAP activated nonmuscle myosin-2C (NM2C) to alter actin organization, inhibiting the mechanical program of metastasis. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Scientists discovered that prolonged treatment of colon cancer cells with insulin-like growth factor 1 receptor (IGF-1R) inhibitors stimulated p70 KDa ribosomal protein S6 kinase 1 (p70S6K1) activation, a well-known kinase signaling for cell survival. They also found that p70S6K1 activation by IGF-1R inhibition was independent of K-Ras and PIK3CA mutations that frequently occur in colon cancer. [Signal Transduction and Targeted Therapy] |
|
|
|
| Through transcriptome sequencing, scientists found that anlotinib treatment upregulated ATPase H+ Transporting V0 Subunit E2 (ATP6V0E2) and other lysosome-related genes expression in human colon cancer. [Cell Death & Disease] |
|
|
|
| A genomewide expression analysis in cell lines led scientists to uncover that activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways were the key mediators for the anti-cancer and chemosensitizing effects of andrographis. [Carcinogenesis] |
|
|
|
| Scientists revealed a protective role for 25-hydroxycholesterol in dextran sulfate sodium(DSS)-induced colitis and the ability of cholesterol 25-hydroxylase to maintain epithelial gut barrier function through ATF3 expression. [Scientific Reports] |
|
|
|
| Knockdown of SNHG16 attenuated cell proliferation, migration, invasion, and EMT of colorectal cancer (CRC) cells. In contrast, miR-124-3p exerted the antitumor effects. Knockdown of miR-124-3p could reverse the effect of sh-SNHG16 on CRC cells. miR-124-3p could directly bind to SNHG16 or MCP-1. MCP-1 acted as a critical effector mediating the role of SNHG16/ miR-124-3p in CRC cells. [Gene Therapy] |
|
|
|
| In a previous study, researchers demonstrated that stimulation of opioid receptors using P-317, a cyclic morphiceptin analog, resulted in the alleviation of acute colitis in mice. The current study assessed the effect of P-317 during colitis and colitis-associated colorectal cancer in mice. [European Journal of Pharmacology] |
|
|
|
|
| Regeneration is influenced by the nutritional state, microbiome, and extracellular matrix. The authors review how all these components cooperate to restore epithelial homeostasis in the intestine after injury. [Developmental Cell] |
|
|
|
|
| Applied Molecular Transport announced that the first patient has been dosed in a randomized, placebo-controlled, double-blind, multicenter Phase IIa study evaluating the efficacy and safety of oral AMT-101 in patients with moderate to severely active ulcerative colitis. [Applied Molecular Transport ] |
|
|
|
| Cerecor, Inc. announced it has resumed the Phase Ib clinical study of CERC-002 in anti-TNF refractory adult crohn’s patients with the lifting of the moratorium on elective endoscopy resulting from the COVID-19 pandemic. [Cerecor, Inc. ] |
|
|
|
|
|
|
|
| The University of Arizona – Tucson, Arizona, United States |
|
|
|
| City of Hope – Monrovia, California, United States |
|
|
|
| USC Lawrence J. Ellison Institute for Transformative Medicine – West Los Angeles, California, United States |
|
|
|
| University of Kentucky – Lexington, Kentucky, United States |
|
|
|
| Emory University – Atlanta, Georgia, United States |
|
|
|
|