Intestinal Cell News Volume 6.39 | Oct 09 2020

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    2020-10-09 | ICN 6.39


    Intestinal Cell News by STEMCELL Technologies
    Vol. 6.39 – 9 October, 2020
    TOP STORY

    Phenotypic Landscape of Intestinal Organoid Regeneration

    By combining quantitative imaging with RNA sequencing, scientists showed the role of endogenous retinoic acid metabolism in initiating transcriptional programs that guide the cell-fate transitions of intestinal epithelium, and identified an inhibitor of the retinoid X receptor that improves intestinal regeneration in vivo.
    [Nature]

    AbstractPress Release

    Pathogen infection studies lacked an optimal culture system. Then she used organoids.
    PUBLICATIONSRanked by the impact factor of the journal

    A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

    The authors report the creation of a uniquely acting HSP70 inhibitor that targets multiple compartments in the cancer cell including mitochondria.
    [Cancer Research]

    Abstract

    Long Noncoding RNA RP11-757g1.5 Sponges miR-139-5p and Upregulates YAP1 Thereby Promoting the Proliferation and Liver, Spleen Metastasis of Colorectal Cancer

    Bioinformatics binding site analysis, Luciferase reporter assay, Ago2 immunoprecipitation assays, RNA pull-down assay, RT-qPCR and Western blotting were utilized to demonstrate that mechanism of RP11-757G1.5 acts as a molecular sponge of miR-139-5p to regulate the expression of YAP1.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    B7-H3 Regulates KIF15-Activated ERK1/2 Pathway and Contributes to Radioresistance in Colorectal Cancer

    In vitro and in vivo functional analyses showed that B7-H3 enhanced resistance against irradiation in colorectal cancer cells by upregulating KIF15 expression via NF-κB, which activated ERK1/2 signaling, a key pathway involved in radioresistance in cancers.
    [Cell Death & Disease]

    Full Article

    Heat Treatment of Galangin and Kaempferol Inhibits Their Benefits to Improve Barrier Function in Rat Intestinal Epithelial Cells: Galangin & Kaempferol Improve IEC-6 Cells Barrier Function

    Two flavonols, galangin and kaempferol, were heated at 100°C for 30 min prior to assessing their effects on barrier function of rat intestinal epithelial cells.
    [Journal of Nutritional Biochemistry]

    AbstractGraphical Abstract

    A Novel Role for Farnesoid X Receptor in the Bile Acid‐Mediated Intestinal Glucose Homeostasis

    Bile acid‐activated farnesoid X receptor enhanced glucose uptake in intestinal epithelial cells by increasing the expression of glucose transporter 2, which depended on ERK1/2 phosphorylation via S1PR2. However, it also reduced the cell energy generation via inhibition of oxidative phosphorylation, which was crucial for intestinal glucose transport.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection in Vitro

    The authors suggest differential ability of specific human milk oligosaccharides (HMOs) in modulating the intestinal barrier and supporting the potential of supplementation with combinations of available HMOs to promote gut health and protect against intestinal inflammatory disorders.
    [Nutrients]

    Abstract

    Non-Muscle Myosin-2 Contractility-Dependent Actin Turnover Limits the Length of Epithelial Microvilli

    Using pharmacological and genetic perturbations in cultured intestinal epithelial cells, investigators found that non-muscle myosin-2C controlled the length of growing microvilli by regulating actin turnover in a manner that required a fully active motor domain.
    [Molecular Biology of the Cell]

    Abstract

    Discovery of Oxyepiberberine as a Novel Tubulin Polymerization Inhibitor and an Anti-Colon Cancer Agent against LS-1034 Cells

    The anti-proliferative effects of six derivatives of oxyepiberberine on colon cancer cells were assessed. Among six derivatives, oxyepiberberine showed the greatest anti-proliferative effect on LS-1034 cells.
    [Investigational New Drugs]

    Abstract

    Request your free copy of the 'The Intestinal Crypt' Wallchart
    REVIEWS

    Three-Dimensional Culture Systems in Gastric Cancer Research

    The authors present the current status of in vitro / ex vivo 3D models of human gastric cancer as a surrogate to in vivo tumors.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Authorizes New IND to Evaluate Impact of Multi-Strain Probiotic DS-01TMon Gut Microbiota of Patients with IBS

    FDA regulatory acceptance enabled a team of gastroenterologists at Beth Israel Deaconess Medical Center to initiate a Phase II randomized, triple-blind, and placebo-controlled clinical trial to investigate the role of the gut microbiome in patients with Irritable Bowel Syndrome, as well as the impact of DS-01™ on both intestinal cells and metabolic output of the native intestinal microbial communities.
    [Seed Health (PR Newswire Inc.)]

    Press Release

    FEATURED EVENT

    The Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

    January 9 – January 12, 2021
    Lake Buena Vista, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Senior Research Technologist – Inflammation and immunity

    Lerner Research Institute – Cleveland, Ohio, United States

    Research Associate – Ex Vivo and In Vivo Models of Colorectal Cancer

    Moffitt Cancer Center – Tempa, Florida, United States

    Postdoctoral Associate – The Relationship between Diet, Metabolism, Microbiome, and Colorectal Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Senior Scientist – Gut Microbiome and Gastrointestinal Physiology

    Chr. Hansen A/S – Hørsholm, Denmark

    Staff Scientist – Molecular Diagnostics & Experimental Therapeutics

    City of Hope – Monrovia, California, United States

    > See All Jobs

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