 | | Vol. 6.43 – 6 November, 2020 |
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| Researchers showed that Forkhead box O and Notch signaling converged on regulation of mitochondrial fission, which in turn provoked stem cell differentiation into goblet cells and paneth cells.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Inhibiting CXCR4 in an experimental cancer medicine study by one week continuous infusion of the small-molecule inhibitor AMD3100 induced an integrated immune response that was detected by transcriptional analysis of paired biopsies of metastases from patients with microsatellite stable colorectal and pancreatic cancer.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators demonstrated that Dronc, the Drosophila ortholog of caspase‐9/2 in mammals, limited the number of intestinal progenitor cells and their entry into the enterocyte differentiation programme.
[EMBO Reports] |
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| Using mice with inducible intestinal epithelial cell-specific deletion of Phb1 and mice with IEC-specific overexpression of Phb1, investigators demonstrated that IEC-specific PHB1 combated intestinal tumorigenesis in the ApcMin/+ mouse model by inhibiting Wnt/β-catenin signaling.
[Oncogene] |
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| m-THPC-photodynamic therapy (PDT) or verteporfin-PDT exhibited significant phototoxicity, inhibited proliferation, and induced the generation of large amounts of reactive oxygen species in colorectal cancer cells.
[Cell Death & Disease] |
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| Scientists examined the mechanism by which copanlisib induces PUMA and its function in chemosensitization and apoptosis. They assessed the roles of FoxO3a and PUMA in the anticancer activity of copanlisib.
[Cell Death & Disease] |
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| Using CRISPR/Cas9 in the colorectal cancer cell line DLD-1, which harbors four POLD1 variants, scientists established heterozygous POLD1-knockout clones with exclusive expression of distinct variants to determine the functional relevance of these variants individually by assessing their impact on ATR pathway activation, DNA replication, and cellular sensitivity to inhibition of ATR or its effector kinase CHK1.
[Scientific Reports] |
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| Researchers found that CASC9 was significantly upregulated in colorectal cancer (CRC) tissues and cell lines compared to normal controls and that aberrant expression was associated with the tumor-node-metastasis stage of CRC.
[Cell Death Discovery] |
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| Both IPEC-J2 cells and porcine middle-jejunum segments were treated with five , 25 and 50 µM gallic acid and mounted in Ussing chambers to determine transepithelial resistance, claudin-1, occludin, zonula occludens-1 protein and mRNA expression. In addition, uptake of L-Glutamate , L-Arginine , L-Lysine and L-Methionine, together with cationic-amino-acid transporter-1 and excitatory-amino-acid transporter-3 expression was evaluated.
[British Journal of Nutrition] |
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| The authors discuss the potential causal link between Cryptosporidium infection and digestive cancer, with particular emphasis on colon cancer, based on increasing clinical, epidemiological and experimental pieces of evidence supporting this association.
[Microorganisms] |
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| BiomX Inc. announced that the first subject has been dosed in a Phase Ia study of BX002, a phage therapy candidate for the treatment of inflammatory bowel disease. The first-in-human study is designed to evaluate the safety, pharmacokinetics, and ability of orally-administered BX002 to deliver viable phage to the gut. The therapy targets strains of Klebsiella pneumoniae that cause strong TH1 immune stimulation and colitis in mouse models of disease and are known to be present at a higher prevalence and abundance in IBD patients relative to healthy individuals.
[BiomX Inc.] |
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| January 21 – January 23
Las Vegas, Nevada, United States |
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| | University of Florida – Jacksonville, Florida, United States |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Moffitt Cancer Center – Tempa, Florida, United States |
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