 | | Vol. 6.46 – 27 November, 2020 |
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| The authors demonstrated that interleukin-33 (IL-33) induced instantaneous peristaltic movement and facilitated Trichuris muris expulsion. They found that IL-33 could be sensed by enterochromaffin cells, inducing release of serotonin.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists analyzed altered gene signatures during colorectal tumor progression, and used a complex of molecular and metabolic assays to study the regulation of metabolism in colorectal cancer cell lines, human patient-derived xenograft mouse models and tumor organoid models.
[Gut] |
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| The authors identified mitochondrial Ca2+ uptake as a central coordinator of stem cell metabolism. Live imaging of genetically encoded metabolite sensors in intestinal stem cells of Drosophila revealed that mitochondrial Ca2+ uptake transiently adapted electron transport chain flux to match energetic demand upon proliferative activation.
[Cell Reports] |
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| A series of in vitro and in vivo experiments were conducted to reveal the role of caudal-related homoeobox transcription factor 2 (CDX2) in the invasion and metastasis of colorectal cancer.
[British Journal of Cancer] |
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| The authors utilized confluent Caco‐2 cell monolayers as an in vitro model of intestinal epithelial cells to investigate the potential role of autophagy in the pathophysiology of cryptosporidiosis.
[Cellular Microbiology] |
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| Foxl1 expression was transiently upregulated only in connective tissue cells during the early period of metamorphic climax and was the highest just beneath the proliferating stem/progenitor cells.
[Scientific Reports] |
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| Investigators report that endothelial cell protein C receptor was expressed in the colon epithelial cells, CD11c+, and CD21+/CD35+ myeloid cells surrounding the crypts in the colon mucosa.
[Scientific Reports] |
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| This report describes the effects of full-length, wild-type APC (fl-APC) on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC increased the expression of genes implicated in cell-cell adhesion, whereas the expression of negative regulators of E-cadherin were decreased.
[Molecular Biology of the Cell] |
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| The authors investigated the molecular effects of physiologically attainable concentration of curcumin in the intestinal lumen on mechanistic target of rapamycin complex 1 signaling in Caco-2 cells.
[Cellular Signalling] |
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| The porcine small intestinal epithelial cell line IPEC-J2 was used to assess the ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury.
[International Immunopharmacology] |
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| Investigators review different adult stem cell derived gastric organoid model systems and focus on their establishment, phenotypic and genotypic characterizations as well as their use in predicting therapy response.
[Cell Death & Differentiation] |
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| PMV Pharmaceuticals, Inc. announced dosing of the first patient in its Phase I/II clinical trial evaluating PC14586, the company’s investigational lead compound that targets the Y220C mutant of p53.
[PMV Pharmaceuticals, Inc.] |
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| September 8 – September 10, 2021
Hinxton, England, United Kingdom |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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