| Vol. 6.47 – 4 December, 2020 |
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| Colorectal cancer (CRC) tumoroids and a mouse model of CRC hepatic metastasis were used to test approaches to modify bone morphogenetic protein signaling and treat CRC. [Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators provide evidence that a thermogenic fat–epithelial cell axis regulated intestinal disease tolerance during experimental colitis. They found that intestinal disease tolerance is a metabolically expensive trait, whose expression was restricted to thermoneutral mice and was not transferable by the microbiota. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists examined the mechanisms of action of LGR4 and LGR5 in parallel using coimmunoprecipitation, proximity ligation, competition binding, and time-resolved FRET assays in whole cells. [Science Signaling] |
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| The authors assessed the expression of the most common intestinal Cytochrome P450 (CYP) enzymes in a human induced pluripotent stem cell-derived human intestinal organoid model, and the suitability of that model to study chemical-induced changes in CYP expression and activity. [Archives of Toxicology] |
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| Responses to the inhibitor of apoptosis protein antagonist Birinapant and oxaliplatin/5-fluorouracil were investigated in 14 colon cancer cell lines, representing the consensus molecular subtypes. [Cell Death & Disease] |
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| The authors describe a new proximity-based profiling method that relies upon a GAL4 driver, termed intestinal-kickout (I-KCKT)-GAL4, exclusively expressed in intestinal progenitor cells. [Development] |
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| Using the intestine of SAMP1/YitFcsJ mice aged 10 to 14 weeks, morphometric alterations in the crypt-villus architecture, intestinal stem cells, crypt cells, and differentiated cells; organoid formation capacity of intestinal crypts; and niche signaling pathways were analyzed and compared with those of age-matched control AKR/J mice. [Inflammatory Bowel Diseases] |
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| Researchers used Mucin-2 (Muc2) knockout mice predisposed to colitis to study intestinal barrier upon chronic inflammation. They used 4-kDa FITC-Dextran assay and transmission electron microscopy to demonstrate the increased intestinal permeability and morphological defects in intercellular junctions in Muc2 knockout mice. [Scientific Reports] |
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| Ginsenoside Rb1 (GRb1) administration not only normalized Hrd1 expression at both the mRNA and protein levels, but also alleviated the endoplasmic reticulum stress response, Fas-related apoptosis, and other colitis symptoms. In intestinal cell line IEC-6, the expression of Hrd1 was significantly decreased by LPS treatment, but was normalized by GRb1. [Acta Pharmacologica Sinica] |
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| Scientists describe how the contribution of stem-cell-derived culture systems have helped the understanding of SARS-CoV-2 pathogenesis. [Cell Stem Cell] |
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| Researchers summarize recent advances in understanding the correlation between Hippo–YAP signaling and intestinal homeostasis, repair, and tumorigenesis, focusing specifically on intestinal stem cell regulation. [Biomedicines] |
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| Deciphera Pharmaceuticals, Inc. announced the completion of its target enrollment in the INTRIGUE Phase III clinical study evaluating the efficacy and safety of QINLOCK® in patients with second-line gastrointestinal stromal tumor. [Deciphera Pharmaceuticals, Inc.] |
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| Bacainn Therapeutics, Inc. announced the successful completion of the company’s Phase I, first-in-human clinical trial of BT051, a novel, orally administered, gut-selective inhibitor of migration and activation of neutrophils. [Bacainn Therapeutics, Inc. (Business Wire, Inc.)] |
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| October 7 – October 10, 2021 Lisbon, Portugal |
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| University of Dundee – Dundee, Scotland, United Kingdom |
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| Technical University of Denmark – Lyngby, Denmark |
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| Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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| Dalhousie University – Halifax, Nova Scotia, Canada |
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| The University of Utah – Salt Lake City, Utah, United States |
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| Lerner Research Institute – Cleveland, Ohio, United States |
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