 | | Vol. 6.48 – 11 December, 2020 |
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| In vitro crypts formed from primary human intestinal epithelial stem cells on a 3D shaped hydrogel scaffold replicated the functional and architectural features of in vivo crypts.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators deconstructed the evolving microenvironment of colitis-associated colon cancer (CAC) by measuring proteomic changes and extracellular matrix organization over time in a mouse model of CAC.
[Nature Communications] |
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| Researchers found that mitochondrial DNA (mtDNA)-mediated STING signaling triggered necroptosis through synergistic IFN and TNF-α signaling in primary IECs.
[Cell Death & Disease] |
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| Scientists showed that hypusinated eukaryotic translation initiation factor 5A promoted growth of colorectal cancer cells by directly regulating MYC biosynthesis at specific pausing motifs.
[Cell Death & Disease] |
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| The authors uncovered the candidate transcriptional factor of hTERT in colorectal cancer (CRC) and explored its role and the corresponding molecular mechanisms in regulating hTERT expression and CRC survival with an aim of developing mechanism‐based combinational targeting therapy.
[Molecular Oncology] |
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| Researchers designed in vitro and in vivo studies to investigate the possibility of targeting colon cancers that exhibit defects in p53.
[Cancer & Metabolism] |
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| Scientists revealed lncRNAs and mRNA expression profiles in intestinal epithelial cells from a mouse model of colitis and expanded the understanding of intestinal epithelial barrier regulation.
[Journal of Cellular and Molecular Medicine] |
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| Investigators assessed the enteric nervous system and the intestinal epithelial barrier in ganglionic segments by combining immunohistochemical, proteomic and transcriptomic approaches, with functional ex vivo analysis of motility and para/transcellular permeability.
[Scientific Reports] |
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| Growth inhibition, apoptosis, DNA integrity and gene expression of catalase were analyzed in LT97 colon adenoma cells. Concentrations of short-chain fatty acids, particularly butyrate, were higher in oat/barley fermentation supernatants, while ammonia levels were significantly lower than in the fermentation control.
[Nutrition and Cancer-An International Journal] |
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| Scientists review colon extracellular matrix physical properties at physiological and pathological states and their bioengineered in vitro reproduction applications to intestinal stem cell studies.
[Cells] |
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| Merck announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending approval of KEYTRUDA, Merck’s anti-PD-1 therapy, as monotherapy for the first-line treatment of adult patients with MSI-H or dMMR colorectal cancer.
[Merck & Co., Inc.] |
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| Bellicum Pharmaceuticals, Inc. announced enrollment and apheresis of the first patient in the Phase I/II clinical trial for BPX-603 in patients with tumors that express human epidermal growth factor 2.
[Bellicum Pharmaceuticals, Inc.] |
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| April 10 – 15, 2021
Virtual |
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| | Aichi Cancer Center – Nagoya, Japan |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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