 | | Vol. 6.49 – 18 December, 2020 |
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| The authors found Fusobacterium nucleatum abundance correlated with high glucose metabolism in patients with colorectal cancer (CRC). Furthermore, F. nucleatum supported carcinogenesis via increasing CRC cell glucose metabolism.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer, scientists generated mice deficient for cyclin A2 in colonic epithelial cells.
[Journal of Clinical Investigation] |
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| Researchers demonstrated an important role for RNF186 in macroautophagy/autophagy activation in colonic epithelial cells and intestinal homeostasis. Mechanistically, RNF186 acts as an E3 ubiquitin-protein ligase for EPHB2 and regulates the ubiquitination of EPHB2.
[Autophagy] |
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| Investigators globally identified ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in intact colorectal cancer cells.
[Genes & Development] |
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| Scientists developed an ex vivo experimental system, based on the intraluminal microinjection of Listeria in untreated, pharmacologically treated, and genetically modified intestinal organoids
[Current Biology] |
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| To describe the relevant cell populations in an unbiased manner, researchers carried out a single-cell transcriptome analysis of the adult murine colon, producing a high-quality atlas of matched colonic epithelium and mesenchyme.
[PLoS Biology] |
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| Clinical parameters of colitis were assessed by colonoscopy, histology, flow cytometry and detection of serum biomarkers; single-cell RNA sequencing and qRT-PCR were used to evaluate the effects of cannabinoids on enterocytes.
[Journal of Crohns & Colitis] |
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| Researchers hypothesized that SOX9 could regulate the function of cancer stem/initiating cells to further facilitate the progression of colorectal cancer (CRC). Stable transfection of shRNAs was used to silence indicated genes. Loss-of-function experiments were conducted to demonstrate the in vitro function of CRC cells.
[Cell Death & Disease] |
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| Scientists found that the expression of miR-21 was negatively correlated with the expression of vacuole membrane protein-1 (VMP1) in colorectal cancer. Transcription of VMP1 activated either by small activating RNA or transcriptional activator GLI3 inhibited miR-21 expression through reducing its transcripts of VMP1-miR-21 and pri-miR-21, while no significant change in miR-21 expression after exogenous overexpression VMP1 in colorectal cancer cell HCT116.
[Cell Death & Disease] |
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| Researchers defined the role of LINC00337 in the malignant phenotypes, especially angiogenesis, of colorectal cancer (CRC) and clarified the underlying molecular basis. Bioinformatic analyses identified promoter region methylation of CNN1 in CRC, which was further validated by BSP and MSP assays.
[Cancer Gene Therapy] |
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| Scientists discuss the strategies of biomarker discovery and summarize the status and assess the utility of previously published biomarkers in colorectal cancer.
[Molecular Therapy] |
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| Nektar Therapeutics announced that the first patient has been dosed in the Phase I/II trial of NKTR-255, Nektar’s investigational IL-15 pathway agonist, in patients with relapsed or refractory head and neck squamous cell carcinoma or colorectal cancer at the START Center for Cancer Care in San Antonio, Texas.
[Nektar Therapeutics] |
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| Celyad Oncology SA announced the successful dosing of the first patient in the expansion cohort of the Phase I alloSHRINK trial for CYAD-101, the company’s allogeneic T cell receptor inhibitory molecule-based, non-gene edited CAR T candidate for the treatment of refractory metastatic colorectal cancer.
[Celyad Oncology SA] |
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| January 7 – 8, 2021
Virtual |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | Aichi Cancer Center – Nagoya, Japan |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | Daiichi Sankyo, Inc. – Basking Ridge, New Jersey, United States |
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| | The University of Utah – Salt Lake City, Utah, United States |
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