Intestinal Cell News Volume 7.04 | Feb 5 2021

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    2020-02-05 | ICN 7.04


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.04 – 5 February, 2021
    TOP STORY

    Sprouty2 Limits Intestinal Tuft and Goblet Cell Numbers through GSK3β-Mediated Restriction of Epithelial IL-33

    The authors asked whether Sprouty2 controls secretory cell differentiation and the response to colitis. They report that colonic epithelial Sprouty2 deletion led to expanded tuft and goblet cell populations.
    [Nature Communications]

    Full Article

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    Cyclodextrin-Based Host-Guest Complexes Loaded with Regorafenib for Colorectal Cancer Treatment

    In vivo application showed that a channel-type formulation optimized the pharmacokinetics and bio-distribution of Regorafenib (Rg). In colitis-associated cancer and CT26 mouse models, RG mannose-modified γ-cyclodextrin was proven to be a targeted, safe and effective anti-tumor nanomedicine that suppressed tumor cell proliferation, lesioned neovascularization, and remodeled tumor microenvironment.
    [Nature Communications]

    Full Article

    Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil

    Combining genetic deletion of phosphoserine aminotransferase with exogenous serine deprivation maximally suppressed the proliferation of colorectal cancer cells and induced profound metabolic defects including diminished nucleotide production.
    [Cancer Research]

    Abstract

    Hsp90-Stabilized MIF Supports Tumor Progression via Macrophage Recruitment and Angiogenesis in Colorectal Cancer

    Scientists demonstrated that a migration inhibitory factor (Mif) deletion reduced colorectal cancer (CRC) tumor growth. Further, they defined a dual role for MIF in CRC tumor progression.
    [Cell Death & Disease]

    Full Article

    Infection of Porcine Small Intestinal Enteroids with Human and Pig Rotavirus A Strains Reveals Contrasting Roles for Histo-Blood Group Antigens and Terminal Sialic Acids

    Researchers established a porcine crypt-derived 3D intestinal enteroids culture system which contains all intestinal epithelial cells identified in vivo and represents a unique physiologically functional model to study rotavirus-glycan interactions in vitro.
    [PLoS Pathogens]

    Full Article

    Identification of Potential Novel Drug Resistance Mechanisms by Genomic and Transcriptomic Profiling of Colon Cancer Cells with p53 Deletion

    The authors characterized colon cancer cells with TP53 deletion, a sub-line derived from HCT116-p53+/+ cells. RNA sequencing and network analyses were performed to identify novel drug resistance mechanisms.
    [Archives of Toxicology]

    Full Article

    A Short Deletion in the DNA Binding Domain of STAT3 Suppresses Growth and Progression of Colon Cancer Cells

    Researchers used the CRISPR-CAS9 gene editing system to delete a short sequence encoding amino acids 400-411 in the DNA binding domain from STAT3 gene in SW480, SW620 and HCT116 colon cancer cells.
    [Aging-Us]

    Full Article

    Circular RNA hsa_circ_0009172 Suppresses Gastric Cancer by Regulation of MicroRNA-485-3p-Mediated NTRK3

    The authors screened the associated circular RNA (circRNA) in gastric cancer and exploring its mechanism. Expression of hsa_circRNA_0009172 was validated in gastric cancer tissues and cell lines after the correlation between hsa_circRNA_0009172 and prognosis was determined.
    [Cancer Gene Therapy]

    Abstract

    Transcriptome Comparisons of In Vitro Intestinal Epithelia Grown under Static and Microfluidic Gut-on-Chip Conditions with In Vivo Human Epithelia

    Scientists determined if dynamic culture conditions affected the gene expression of Caco-2 cells cultured statically or dynamically in a gut-on-chip device and how these gene expression patterns compared to that of intestinal segments in vivo.
    [Scientific Reports]

    Full Article

    Neutral Endopeptidase Depletion Decreases Colon Cancer Cell Proliferation and TGF-β1 Synthesis in Indirect Co-Cultures with Normal Colon Fibroblasts

    Investigators evaluated the role of neutral endopeptidase in colon cancer (CC) promotion in conditions of indirect co-culture of CC cells with normal colon fibroblasts or their conditioned medium.
    [Clinical and Translational Oncology]

    Abstract

    Explore scientific events this February with the Science Events Calendar.
    REVIEWS

    From Inflammation to Colitis-Associated Colorectal Cancer in Inflammatory Bowel Disease: Pathogenesis and Impact of Current Therapies

    Scientists present an overview of the current knowledge of colitis-associated cancer (CAC) in inflammatory bowel disease (IBD) patients, focusing on the role of inflammation in the pathogenesis of CAC and the potential for IBD drugs to interfere with the process of carcinogenesis by reducing the inflammatory process or by modulating pathways directly involved in carcinogenesis.
    [Digestive and Liver Disease]

    Abstract

    INDUSTRY AND POLICY NEWS

    Bristol Myers Squibb Application for Zeposia® (Ozanimod) for the Treatment of Ulcerative Colitis Accepted for Filing with Priority Review by US Food and Drug Administration

    Bristol Myers Squibb announced that the FDA has accepted its supplemental New Drug Application for Zeposia® for the treatment of adults with moderately to severely active ulcerative colitis.
    [Bristol Myers Squibb]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Associate Professors – Microbes, Development and Health

    Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China

    Postdoctoral Position – Developmental Cancer Biology/Quantitative Cell Biology

    Max Planck Institute of Molecular Physiology – Dortmund, Germany

    Postdoctoral Researcher – Intestinal Epithelial Barrier

    BioMed X Institute – Heidelberg, Germany

    Postdoctoral Position – Colorectal Cancer

    University of Freiburg – Freiburg, Germany

    Postdoctoral Fellow – Blood-Based Biomarkers

    Aichi Cancer Center – Nagoya, Japan

    > See All Jobs

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