| Vol. 7.05 – 12 February, 2021 |
| |
|
|
| Colibactin’s distinct mutational signature is reflected in human colorectal cancer, suggesting a causal link. Scientists investigated its transformation potential using organoids from primary murine colon epithelial cells. [Nature Communications] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers found that epithelial-mesenchymal transition (EMT)-colorectal cancer cells promoted the M2-like polarization of macrophages by directly transferring exosomes to macrophages, leading to a significant increase of miR-106b level in macrophages. [Molecular Therapy] |
|
|
|
| The authors demonstrated that optimized human intestinal organoids enabled better simulation of the native human intestinal epithelium, and they were significantly more susceptible to EV-A71 than CVA16. [Stem Cell Reports] |
|
|
|
| Scientists demonstrated the generation of enterocyte-like cells by culturing human iPSC-derived intestinal progenitor cells on a collagen vitrigel membrane. [Stem Cell Reports] |
|
|
|
| Investigators elucidated the function of NEDD4 in colon cancer (CC) progression and its mechanism of action. NEDD4 was abundantly expressed in CC tissues and cells, and the overexpression of NEDD4 promoted the growth and metastasis of xenograft tumors as well as the tumorigenesis rate of primary CC in mouse models. [RNA Biology] |
|
|
|
| Researchers investigated the effect and mechanisms of corticosteroid prednisolone on epithelial barrier using Crohn’s disease (CD) patient-derived intestinal organoids. 3D intestinal organoids were generated from colon biopsies of inactive CD patients. [Journal of Molecular Medicine] |
|
|
|
| Investigators provide evidence for a function of the glycolipid-lectin mechanism in transcytosis across enterocytes in the mouse intestine. [Communications Biology] |
|
|
|
| The authors explored the possible role of M2 macrophage-derived exosomal miR-155-5p in regard to immune escape of colon cancer cells. [Molecular Therapy-Oncolytics] |
|
|
|
| An intestinal epithelial cell (IEC) line was applied with diclofenac sodium and its activity was detected by CCK-8. IEC-6 and RBL-2H3 were co-cultured to evaluate the permeability of intestinal epithelial cells by detecting the concentration of potassium ion and LDH. [Inflammation] |
|
|
|
|
| Studies on the role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer are discussed, and the potential for development of targeted drugs are summarized. [Nature Reviews Gastroenterology & Hepatology] |
|
|
|
|
| The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. announced a strategic research and development collaboration to expand the evaluation of Mirati’s two investigational small molecule, potent and selective KRAS inhibitors – adagrasib, a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and in combination with other agents – which target two of the most frequent KRAS mutations in cancer. [Mirati Therapeutics, Inc.] |
|
|
|
|
| October 21 – 24, 2021 Minneapolis, Minnesota, United States |
|
|
|
|
|
| Duke University – Durham, North Carolina, United States |
|
|
|
| Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China |
|
|
|
| Max Planck Institute of Molecular Physiology – Dortmund, Germany |
|
|
|
| BioMed X Institute – Heidelberg, Germany |
|
|
|
| University of Freiburg – Freiburg, Germany |
|
|
|
|