Intestinal Cell News Volume 7.05 | Feb 12 2021

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    2020-12-02 | ICN 7.05


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.05 – 12 February, 2021
    TOP STORY

    Genomic Aberrations after Short-Term Exposure to Colibactin-Producing E. coli Transform Primary Colon Epithelial Cells

    Colibactin’s distinct mutational signature is reflected in human colorectal cancer, suggesting a causal link. Scientists investigated its transformation potential using organoids from primary murine colon epithelial cells.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Tumor-Derived Exosomal MicroRNA-106b-5p Activates the Interaction between EMT-Cancer Cells and M2-Subtype TAMs to Facilitate Colorectal Cancer Metastasis

    Researchers found that epithelial-mesenchymal transition (EMT)-colorectal cancer cells promoted the M2-like polarization of macrophages by directly transferring exosomes to macrophages, leading to a significant increase of miR-106b level in macrophages.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

    The authors demonstrated that optimized human intestinal organoids enabled better simulation of the native human intestinal epithelium, and they were significantly more susceptible to EV-A71 than CVA16.
    [Stem Cell Reports]

    AbstractFull Article

    Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies

    Scientists demonstrated the generation of enterocyte-like cells by culturing human iPSC-derived intestinal progenitor cells on a collagen vitrigel membrane.
    [Stem Cell Reports]

    Full Article

    NEDD4 Triggers FOXA1 Ubiquitination and Promotes Colon Cancer Progression under MicroRNA-340-5p Suppression and ATF1 Upregulation

    Investigators elucidated the function of NEDD4 in colon cancer (CC) progression and its mechanism of action. NEDD4 was abundantly expressed in CC tissues and cells, and the overexpression of NEDD4 promoted the growth and metastasis of xenograft tumors as well as the tumorigenesis rate of primary CC in mouse models.
    [RNA Biology]

    Abstract

    Corticosteroid Enhances Epithelial Barrier Function in Intestinal Organoids Derived from Patients with Crohn’s Disease

    Researchers investigated the effect and mechanisms of corticosteroid prednisolone on epithelial barrier using Crohn’s disease (CD) patient-derived intestinal organoids. 3D intestinal organoids were generated from colon biopsies of inactive CD patients.
    [Journal of Molecular Medicine]

    Full Article

    Glycolipid-Dependent and Lectin-Driven Transcytosis in Mouse Enterocytes

    Investigators provide evidence for a function of the glycolipid-lectin mechanism in transcytosis across enterocytes in the mouse intestine.
    [Communications Biology]

    Full Article

    M2 Macrophage-Derived Exosomal MicroRNA-155-5p Promotes the Immune Escape of Colon Cancer by Downregulating ZC3H12B

    The authors explored the possible role of M2 macrophage-derived exosomal miR-155-5p in regard to immune escape of colon cancer cells.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    Effects of Mast Cells Induced by NSAIDs Impair Intestinal Epithelial Barrier Function In Vivo and In Vitro

    An intestinal epithelial cell (IEC) line was applied with diclofenac sodium and its activity was detected by CCK-8. IEC-6 and RBL-2H3 were co-cultured to evaluate the permeability of intestinal epithelial cells by detecting the concentration of potassium ion and LDH.
    [Inflammation]

    Abstract

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    REVIEWS

    The Role of Farnesoid X Receptor in Metabolic Diseases, and Gastrointestinal and Liver Cancer

    Studies on the role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer are discussed, and the potential for development of targeted drugs are summarized.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    MD Anderson and Mirati Therapeutics Announce KRAS Strategic Research and Development Collaboration in Solid Tumors

    The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. announced a strategic research and development collaboration to expand the evaluation of Mirati’s two investigational small molecule, potent and selective KRAS inhibitors – adagrasib, a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and in combination with other agents – which target two of the most frequent KRAS mutations in cancer.
    [Mirati Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Colorectal Cancer

    October 21 – 24, 2021
    Minneapolis, Minnesota, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate Position – Tumor Immunology/Immunotherapy

    Duke University – Durham, North Carolina, United States

    Associate Professors – Microbes, Development and Health

    Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China

    Postdoctoral Position – Developmental Cancer Biology/Quantitative Cell Biology

    Max Planck Institute of Molecular Physiology – Dortmund, Germany

    Postdoctoral Researcher – Intestinal Epithelial Barrier

    BioMed X Institute – Heidelberg, Germany

    Postdoctoral Position – Colorectal Cancer

    University of Freiburg – Freiburg, Germany

    > See All Jobs

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