 | | Vol. 7.06 – 19 February, 2021 |
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| Long non-coding RNA (lncRNA)-SLCC1 interacted with AHR and transcriptionally activated hexokinase 2 expression, the crucial enzyme in glucose metabolism, thereby driving the glycolysis pathway and accelerating colorectal cancer tumor growth.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that during pregnancy, administration of a diet rich in the aryl hydrocarbon receptor (AHR) ligand indole-3-carbinole, or of breast milk, activated AHR and prevented necrotizing enterocolitis in newborn mice by reducing Toll-like receptor 4 signaling in the newborn gut.
[Nature Communications] |
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| An in vitro model using human colon organoids was established by 60 weeks of inflammatory stimulation. The key gene for mucosal injury caused by long-term inflammation was identified by microarray analysis. An in vivo model was established by xenotransplantation of organoids into mouse colonic mucosa.
[Journal of Crohns & Colitis] |
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| The authors found that glycogen synthase kinase 3 inhibitors exhibited a strong synergistic effect with poly ADP-ribose polymerase (PARP) inhibitors in a panel of colorectal cancer cell lines with diverse genetic backgrounds.
[Cell Death & Disease] |
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| Researchers demonstrated that SuFu Negating Protein 1 (SNEP1) acted as a novel feedback regulator of hedgehog (Hh) signaling by destabilizing SuFu and promoting tumor growth and anti-Hh resistance.
[Cell Death & Disease] |
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| A combination of lovastatin and 2-deoxy-D-glucose synergistically reduced cell viability, arrested cells in the G2/M phase, and induced apoptosis. The combined treatment also reduced cellular oxygen consumption and extracellular acidification rate, resulting in decreased production of ATP and lower steady-state ATP levels.
[Acta Pharmacologica Sinica] |
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| Scientists used multiple colorectal cancer (CRC) cell lines to investigate the growth-inhibitory effect of crenolanib and its effect in combination with other cytotoxic agents. Primary cultures of patient-derived organoids, a model that reflected the heterogeneity of clinical CRC, were used to further validate the effects of crenolanib.
[Molecular Cancer Research] |
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| In colitis crypts, a notable cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and the ligand EDA-A2, suppressed colonic stemness and epithelial repair by inhibiting β-catenin/c-Myc. In differentiated intestinal epithelial cells, miR-494-3p inhibited macrophage recruitment, M1 activation and EDA-A2 secretion by targeting IKKβ/NF-κB in colitis.
[Communications Biology] |
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| Researchers report the consequences of silencing desmocollin-2 (Dsc2) on intestinal epithelial cell barrier function in vivo using mice with inducible intestinal-epithelial specific Dsc2 knockdown.
[Molecular Biology of the Cell] |
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| The authors present an overview of the multiple context-dependent functions of YAP and TAZ in regulating cell fate decisions in stem cells and organoids, as well as their mechanisms of controlling programmed cell death pathways in cancer.
[Cellular and Molecular Life Sciences] |
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| Taiga Biotechnologies, Inc. announced that a colorectal cancer patient at the Davidoff Cancer Center, Beilenson Hospital, Rabin Medical Center, Petach Tikva, was the first recipient of a treatment designed to treat drug-resistant solid tumors in the company’s recently approved Israeli trial.
[Taiga Biotechnologies, Inc. (Business Wire, Inc.)] |
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| October 27 – 29, 2021
Tokyo, Japan |
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| | Aerotek Scientific – Saint Louis, Missouri, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China |
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| | Max Planck Institute of Molecular Physiology – Dortmund, Germany |
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| | University of Freiburg – Freiburg, Germany |
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