 | | Vol. 7.07 – 26 February, 2021 |
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| The impact of endoplasmic reticulum stress induced by thapsigargin on serine protease secretion was studied using either human intestinal cells lines or organoids.
[Journal of Crohn’s and Colitis] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Genetic ablation or depletion of PPM1A in cells, organoids, and mice elicited an enhanced Yes-associated protein (YAP)/TAZ cytoplasmic retention and resulted in the diminished cell proliferation, severe gut regeneration defects in colitis, and impeded liver regeneration upon injury.
[PLoS Biology] |
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| The authors found that exosomes derived from metastatic colorectal cancer (CRC) cell line SW620 promoted migration, invasion, and epithelial-mesenchymal transition of CRC cells.
[Molecular Therapy-Nucleic Acids] |
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| Researchers investigated the roles of exosomes during total body irradiation-induced intestinal injury in vivo and in vitro.
[Acta Pharmacologica Sinica] |
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| Investigators identified differentially expressed HEPH, CDX2 and miR‐24‐3p in colon cancer (CC) through bioinformatics analyses, and validated their expression in CC tissues and cells.
[Journal of Cellular and Molecular Medicine] |
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| IL-1β decreased the expression of the LXR target gene ABCA1 in cultured intestinal epithelial cells. The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 mitogen-activated protein kinase, and the expression of CCL-28 and IL-8 in IL-1β-stimulated Caco-2 cells.
[Inflammatory Bowel Diseases] |
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| Scientists demonstrated how targeting SOAT1 promotes YAP expression by elevating cellular cholesterol content in colon cancer cells.
[Cell Death Discovery] |
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| The authors investigated the molecular mechanisms underlying BK3C231-induced cytoprotection and the involvement of the Nrf2/ARE pathway.
[Scientific Reports] |
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| Researchers investigated intra-cellular lipid disturbances induced by adenomatous polyposis coli (APC) gene mutations in intestinal organoids using a reversed-phase ultra-high-performance liquid chromatography mass spectrometry-based lipid profiling method.
[Bioscience Reports] |
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| The authors summarize the methods used to generate and cryopreserve intestinal organoids in farm animals, present their phenotypes and discuss current and future applications of this innovative culture system of the digestive epithelium.
[Veterinary Research] |
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| Compugen Ltd. announced the expansion of its clinical collaboration agreement with Bristol Myers Squibb. Under the amended agreement, Bristol Myers Squibb will supply Opdivo®, its PD-1 inhibitor, for Compugen’s Phase Ib cohort expansion study designed to assess COM701, Compugen’s first-in-class anti-PVRIG antibody, in combination with Opdivo® in selected cancer indications.
[Compugen Ltd.] |
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| November 17 – 19, 2021
Virtual |
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| | AMOLF – Amsterdam, Netherlands |
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| | Aerotek Scientific – Saint Louis, Missouri, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China |
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| | Max Planck Institute of Molecular Physiology – Dortmund, Germany |
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