 | | Vol. 7.08 – 5 March, 2021 |
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| The authors took advantage of knock-in mice harboring transgenic β-catenin alleles with mutations that specifically impair the recruitment of N- or C-terminal transcriptional co-factors.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists addressed the prevalence of transposition in a somatic tissue, exploiting the Drosophila midgut as a model.
[EMBO Journal] |
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| Researchers found that lymph node metastasis (LNM)-gastric cancer (GC) specifically educated bone marrow (BM)-mesenchymal stem cells (MSC) via secretory exosomes. Exosomal Wnt5a was identified as key protein mediating LNM-GCs education of BM-MSCs, which was verified by analysis of serum exosomes collected from GC patients with LNM.
[Oncogene] |
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| The authors elucidated the roles of kinesin superfamily protein 26A in gastric cancer and its underlying molecular mechanism in regulating tumor invasion and metastasis.
[Oncogene] |
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| Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.
[Cancer Science] |
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| Researchers characterized the activities of two depeptidyl peptidase-IV inhibitory peptides, VLATSGPG and LDKVFER, using the Caco-2 monolayer model for the intestine.
[Journal of Agricultural and Food Chemistry] |
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| The authors explored whether a heterozygous adenomatous polyposis coli (APC) mutation induced molecular defects underlying tumorigenic transformation and how different APC germline mutations predict disease severity.
[Scientific Reports] |
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| Researchers retrospectively evaluated the outcomes of single-unit cord blood transplantation in 1577 patients aged ≥60 years with acute myeloid leukemia in Japan between 2002 and 2017.
[Molecules] |
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| Scientists focused on the individual and combined effect of apigenin and chrysin on clonogenicity, apoptosis, metastasis related behaviors of colorectal cancer cells by colony formation assay, cell scratch assay, flow cytometry, and transwell assay.
[IUBMB Life] |
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| Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.
[International Journal of Clinical Oncology] |
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| To evaluate the sensitization mechanism of peanut allergen Ara h 3, Caco‐2 cells as the model, which has the similar structure and function to differentiated small intestinal epithelial cells.
[Journal of the Science of Food and Agriculture] |
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| Unfortunately, most of the newly designed metal-based complexes exhibit lack of selectivity against cancer cells, low solubility and permeability, high dose-limiting toxicity, and emergence of resistances. Nanodelivery systems enable the incorporation of metallodrugs at adequate payloads, solving the above-referred drawbacks.
[Drug Delivery and Translational Research] |
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| Knight Therapeutics, Inc. announced the Canadian commercial availability of IBSRELA, a first-in-class therapy for the treatment of IBS with constipation in adults.
[Knight Therapeutics Inc.] |
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| June 14 – 18, 2021
Virtual |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| | AMOLF – Amsterdam, Netherlands |
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| | Duke University – Durham, North Carolina, United States |
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| | Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China |
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| | Max Planck Institute of Molecular Physiology – Dortmund, Germany |
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