 | | Vol. 7.20 – 19 March, 2021 |
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| Scientists established organoid cultures from healthy esophageal biopsies and confirmed the esophageal origin of those organoids by qRT-PCR analysis of esophageal-specific gene expression.
[Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that mesenchymal stem cells differentiated into cancer-associated fibroblasts, induced by the exosomes derived from gastric cancer cells.
[Cell Death & Disease] |
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| Combined bulk transcriptomic and single-cell RNA-sequencing analysis revealed decreased gene expression of markers for differentiated cells in patient-derived organoids derived from metastatic lesions.
[Stem Cell Reports] |
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| In a Caco-2 cell model of dietary fat-induced intestinal epithelial cell cytotoxicity, oxidative stress and barrier impairment, researchers investigated the relative protection afforded by an anthocyanin-rich bilberry extract or resveratrol.
[Food & Function] |
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| Researchers investigated the effect and mechanism of β-glucan prepared from Lignosus rhinocerotis using an enzymatic method on epithelial restitution during intestinal mucosal damage.
[Journal of Ethnopharmacology] |
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| C10 significantly inhibited the proliferation of HCT116 and HT29 colon cancer cells by blocking the cell cycle at the G2/M phase.
[Toxicology and Applied Pharmacology] |
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| Colon cancer cell lines were treated with different doses of tectoridin. Then, CCK8 and clone formation experiments were performed to detect cell proliferation.
[Molecular and Cellular Biochemistry] |
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| Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines.
[PLoS One] |
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| Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
[Biochemical Genetics] |
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| Scientists give an overview of the differentiation between ileal and colonic Crohn’s disease using data in the context of epidemiology, genetics, macroscopic differences such as creeping fat and histological findings.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors analyzed the CXCL8-CXCR1/2 axis related signaling pathways and ncRNAs in ulcerative colitis (UC), as well as recent advances in the understanding of the CXCL8-CXCR1/2 axis inhibition as a therapeutic strategy against UC.
[Biomedicine & Pharmacotherapy] |
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| Emulate, Inc., launched the Emulate Colon Intestine-Chip for researchers investigating inflammatory intestinal diseases, which will allow researchers to recapitulate specific human colon cell functionality, gain a greater understanding of mechanisms of inflammation, and investigate potential drug targets.
[Emulate, Inc.] |
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| Anokion SA announced that the company has initiated patient dosing in the multiple ascending dose portion of its Assessment of KAN-101 in Celiac Disease disease, a Phase I clinical trial evaluating KAN-101 for the treatment of individuals with celiac disease.
[Anokion SA] |
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| April 19 – 23, 2021
Virtual |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Chr. Hansen A/S – Hørsholm, Denmark |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| | AMOLF – Amsterdam, Netherlands |
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