 | | Vol. 7.11 – 26 March, 2021 |
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| Researchers showed that the cytoplasmic pool of fat mass and obesity-associated protein impeded cancer stem cellabilities in colorectal cancer through its N6,2’-O-dimethyladenosine (m6Am) demethylase activity.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors studied the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations and explored the effect of increased MSI1 levels in response to treatment.
[Cancer Research] |
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| Quantitative real-time PCR, western blot and immunohistochemistry were utilized to detect the expression profiles and prognostic significance of SPHK2 in gastric cancer.
[Oncogene] |
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| The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research] |
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| By using ex vivo 3D organoid cultures and molecular approaches we observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
[Development] |
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| CRISPR-Cas9 and shRNA were used to eliminate TFAP2A expression in HCT116 and a panel of colon cancer cell lines.
[Molecular Cancer Research] |
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| In vitro colon organoid culture was utilized to assess junction-related gene expression by qPCR and trans-epithelial resistance. In silico analyses of human inflammatory bowel disease and colon cancer databases were performed.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology] |
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| Scientists investigated whether luteolin exhibited its anticancer effects by induction of apoptosis and autophagy in a p53-dependent manner in colon cancer cells.
[Nutrition and Cancer-An International Journal] |
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| Neoadjuvant therapy is becoming the standard of care for an increasing number of tumor types. Currently, colon cancer patients are still routinely treated with up-front surgery, and neoadjuvant systemic therapy is not yet standard.
[Cancer Management and Research] |
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| Hutchison China MediTech Limited has initiated a Phase Ib/II study of surufatinib in combination with BeiGene’s tislelizumab in patients with advanced solid tumors in the US and Europe.
[Hutchison China MediTech Limited] |
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| Four female and six male researchers are to receive the Heinz Maier-Leibnitz Prize this year, the top award for early career investigators in Germany. The prizes are each worth €20,000 and will be presented at an award ceremony on 4 May that is to be held virtually due to the coronavirus pandemic.
[DFG (EurekAlert!)] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Chr. Hansen A/S – Hørsholm, Denmark |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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