 | | Vol. 7.13 – 16 April, 2021 |
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| The authors generated intestinal goblet cells from human epidermal stem cells with two small molecular inhibitors Repsox and CHIR99021 in the presence of basic fibroblast growth factor and bone morphogenetic protein 4 at high efficiency of conversion for a short time.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Through a series of studies spanning in vitro efferocytosis, ex vivo intestinal organoids, and in vivo Cre-mediated deletion of Paneth cells, researchers showed that Paneth cells mediate apoptotic cell uptake of dying neighbors.
[Current Biology] |
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| Researchers showed that untransformed intestinal epithelial cell layers initiate immediate focal contractions, affecting hundreds to thousands of epithelial cells, in response to bacterial infection.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists leveraged a lab-developed four-dimensional culture model by a magnetic responsive alginate-based hydrogel to rotating magnets that could mimic stress stimuli in gastric cancer.
[Biofabrication] |
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| Investigators report that SARS-CoV-2 productively infected both proximally and distally patterned human induced pluripotent stem cell-derived intestinal organoids, leading to the release of infectious viral particles while stimulating a robust transcriptomic response, including a significant upregulation of interferon-related genes that appeared to be conserved across multiple epithelial cell types.
[Stem Cell Reports] |
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| Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.
[Cancer Cell International] |
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| Peptides from milk proteins is gaining popularity in various therapeutics including human cancer. Researchers investigated the anti-cancerous and anti-inflammatory properties of camel whey protein hydrolysates
[Scientific Reports] |
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| Platelet-derived growth factor receptor-α (PDGFRα)-positive intestinal cells were distributed widely in the lamina propria, smooth muscles, and serosal layers.
[Scientific Reports] |
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| The expression of miR-98 in CD44+ gastric cancer stem cells (GCSCs) was verified by RT-PCR. The miR-98 was overexpressed in CD44+ GCSCs by Lentivirus.
[Life Sciences] |
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| Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
[Nature Metabolism] |
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| The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
[Genes & Immunity] |
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| AzurRx BioPharma, Inc. announced that it has initiated its Phase II RESERVOIR clinical trial of a proprietary oral formulation of micronized niclosamide for the treatment of COVID-19 related gastrointestinal infections.
[AzurRx BioPharma, Inc.] |
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| June 5 – 10, 2022
Ventura, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Emory University – Atlanta, Georgia, United States |
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| | Technische Universität Dresden – Dresden, Germany |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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