 | | Vol. 7.14 – 23 April, 2021 |
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| Researchers characterized intestinal goblet cells (GCs) expression diversity and defined how a specific GC subtype, localized in the intercrypt surface epithelium, functionally contributed to the formation of the mucus barrier.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that that Golgi membrane protein 1 (GOLM1) suppressed colorectal tumorigenesis via maintenance of intestinal epithelial barrier.
[Signal Transduction and Targeted Therapy] |
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| The authors epigenetically characterized human colorectal cancer using de novo chromatin state discovery on a library of different patient-derived organoids.
[Nature Communications] |
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| Investigators developed targeted organoid sequencing (TORNADO-seq), a high-throughput, high-content drug discovery platform that uses targeted RNA-seq to monitor the expression of large gene signatures for the detailed evaluation of cellular phenotypes in organoids.
[Cell Reports] |
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| The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics] |
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| Galectin 3-binding protein (Lgals3bp) suppressed NF-κB through the downregulation of TAK1 in colon epithelial cells.
[Cell Death Discovery] |
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| Scientists characterized innate immune responses of human and murine colonoids to bacteria and host products and the role of IL-37/single Ig IL-1 related receptor in regulating these responses.
[Scientific Reports] |
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| The clinical significance and biological function of miR-1253 in the development of colon cancer was investigated. The expression of miR-1253 was identified in colon cancer tissues and cell lines by qRT-PCR.
[Clinical and Experimental Medicine] |
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| Researchers investigated the association between tropomyosin receptor kinase (TrkB/C) with homeobox C6 (HOXC6) and a disintegrin and metalloproteinase domain‑containing 8 (ADAM8) in the induction of drug‑resistant colon cancer cell metastasis.
[Molecular Medicine Reports] |
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| Scientists discuss the link between mucin expression patterns and patient survival and propose mucins as prognosis biomarkers of epithelial cancers.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
[Genes & Immunity] |
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| Bristol Myers Squibb announced that Opdivo, in combination with fluoropyrimidine- and platinum-containing chemotherapy, was approved by the FDA for the treatment of patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma, regardless of PD-L1 expression status.
[Bristol Myers Squibb] |
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| A scientist at the University of Toronto (U of T) has been jointly awarded a 2021 Canada Gairdner International Award for research that has helped revolutionize treatments for type 2 diabetes, obesity and intestinal disorders.
[University of Toronto] |
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| June 19 – 24, 2022
Smithfield, Rhode Island, United States |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | OakRidge Institute of Science and Education – Ames, Iowa, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Emory University – Atlanta, Georgia, United States |
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| | Technische Universität Dresden – Dresden, Germany |
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