 | | Vol. 7.15 – 30 April, 2021 |
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| The authors examined processes governing the size of stem cell zones. They improved the viability and homogeneity of intestinal organoid cultures to enable long-term time-lapse imaging of multiple organoids in parallel.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified microRNA-146a as a major negative regulator of colonic inflammation and associated tumorigenesis by modulating IL-17 responses.
[Nature Communications] |
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| 45 patients with microsatellite instability-high/mismatch repair-deficient gastrointestinal tumors, including gastric cancer, colorectal cancer, cholangiocarcinoma, small intestine cancer, pancreatic cancer, and duodenal cancer, receiving PD-1 blockade were analyzed.
[Clinical Cancer Research] |
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| Intestinal epithelial cells display hyperproliferation and increased antigen presentation in active colon cancer. Further analysis revealed that genes related to the immune response, DNA transcription, protein processing and ion transport remained dysregulated even after budesonide-induced remission.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| The authors showed that glutamine was dispensable for the survival of ovarian and colon cancer cells while it is required for their proliferation.
[Cellular and Molecular Life Sciences] |
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| Scientists studied the effects of palmitoylethanolamide on colon cancer cell proliferation, migration and cell cycle as well as its effects in a murine model of colon cancer.
[Cancers] |
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| Investigators describe an approach to generate gastruloids that have a more complete antero-posterior development.
[Stem Cell Reports] |
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| Myh9 deletion disturbed cell junctions and impaired intestinal lumen barrier integrity, promoting the necroptosis of epithelial cells.
[Stem Cell Reports] |
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| Researchers investigated the association between tropomyosin receptor kinase B/C (TrkB/C) with homeobox C6 and a disintegrin and metalloproteinase domain‑containing 8 in the induction of drug‑resistant colon cancer cell metastasis.
[Molecular Medicine Reports] |
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| Investigators review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.
[Autophagy] |
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| Scientists discuss the link between mucin expression patterns and patient survival and propose mucins as prognosis biomarkers of epithelial cancers.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| Landos Biopharma announced that the company dosed the first patient in a Phase Ib study of NX-13 for ulcerative colitis (UC). NX-13 is Landos’ potentially first-in-class, novel, orally administered, gut-restricted NLRX1 agonist for the treatment of UC and Crohn’s disease.
[Landos Biopharma] |
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| June 21 – 24, 2021
Virtual |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | OakRidge Institute of Science and Education – Ames, Iowa, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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