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| Investigators showed that EGF was the major fate determinant distinguishing the surface and inner part of human gastric glands. [Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis. [Molecular Cell] |
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| Researchers showed that the YAP‐TEAD transcription factor was a key downstream effector of Wnt signaling in the intestine. [EMBO Journal] |
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| Scientists provide genetic evidence that mTOR activation promoted proliferation and inhibited differentiation of Lgr5+ gastric epithelial progenitors in gastric homeostasis and tumorigenesis. [Cell Reports] |
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| The authors showed that the septate junction protein Neuroglian was expressed in intestinal stem cells and enteroblasts within the fly intestine. [Stem Cell Reports] |
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| Researchers showed that SEPS increased the proliferation and survival of intestinal epithelial cells during dextran sulfate sodium stimulation. [International Journal of Biological Macromolecules] |
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| Investigators described an in vitro organ-on-chip model that emulated in vivo tissue structure and the tumor microenvironment to better understand intravasation, an early step in metastasis. [iScience] |
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| The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 in colon cancer stem cells. [Laboratory Investigation] |
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| Scientists investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasized the role of cardamonin as an anti-inflammatory molecule. [Biomolecules] |
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| Using manipulation of different genetic pathways such as EGFR, JAK-STAT and Notch that caused dysplastic phenotypes in the Drosophila gut, researchers found that concomitant aneuploidy induction by impairment of the Spindle Assembly Checkpoint consistently led to a more severe progression of intestinal dysplasia or tumorigenesis. [Biology Open] |
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| Scientists discuss recent progress regarding the identification of unknown hypermethylated genes in colon cancers and IBD, as well as their possible role in clinical practice, which will have important clinical significance, particularly in the era of the personalized medicine. [Life] |
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| XBiotech announced that it had reached an agreement to supply its new cancer drug XB20-01 to INSERM, and its Federation of Digestive Oncology group. [XBiotech (GlobeNewswire, Inc.)] |
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| May 25 – 27, 2021 Virtual |
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| Case Western Reserve University – Cleveland, Ohio, United States |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| Columbia University Medical Center – New York, New York, United States |
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| Research Center for Molecular Medicine – Vienna, Austria |
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