Intestinal Cell News Volume 7.16 | May 7 2021

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    ICN 7.16 | May 7 2021


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.16 – 7 May, 2021
    TOP STORY

    EGF and BMPs Govern Differentiation and Patterning in Human Gastric Glands

    Investigators showed that EGF was the major fate determinant distinguishing the surface and inner part of human gastric glands.
    [Gastroenterology]

    AbstractFull ArticlePress Release

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    PUBLICATIONSRanked by the impact factor of the journal

    The ZMYND8-Regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability

    Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis.
    [Molecular Cell]

    AbstractGraphical Abstract

    Wnt and Src Signals Converge on YAP-TEAD to Drive Intestinal Regeneration

    Researchers showed that the YAP‐TEAD transcription factor was a key downstream effector of Wnt signaling in the intestine.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    mTOR Signaling Regulates Gastric Epithelial Progenitor Homeostasis and Gastric Tumorigenesis via MEK1-ERKs and BMP-Smad1 Pathways

    Scientists provide genetic evidence that mTOR activation promoted proliferation and inhibited differentiation of Lgr5+ gastric epithelial progenitors in gastric homeostasis and tumorigenesis.
    [Cell Reports]

    AbstractGraphical Abstract

    Neuroglian Regulates Drosophila Intestinal Stem Cell Proliferation through Enhanced Signaling via the Epidermal Growth Factor Receptor

    The authors showed that the septate junction protein Neuroglian was expressed in intestinal stem cells and enteroblasts within the fly intestine.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Protective Effects of Sulfated Polysaccharide from Enterobacter cloacae Z0206 against DSS-Induced Intestinal Injury via DNA Methylation

    Researchers showed that SEPS increased the proliferation and survival of intestinal epithelial cells during dextran sulfate sodium stimulation.
    [International Journal of Biological Macromolecules]

    Abstract

    Human Colorectal Cancer-on-Chip Model to Study the Microenvironmental Influence on Early Metastatic Spread

    Investigators described an in vitro organ-on-chip model that emulated in vivo tissue structure and the tumor microenvironment to better understand intravasation, an early step in metastasis.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

    The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 in colon cancer stem cells.
    [Laboratory Investigation]

    Full Article

    Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

    Scientists investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasized the role of cardamonin as an anti-inflammatory molecule.
    [Biomolecules]

    Full Article

    Aneuploidy Facilitates Dysplastic and Tumorigenic Phenotypes in the Drosophila Gut

    Using manipulation of different genetic pathways such as EGFR, JAK-STAT and Notch that caused dysplastic phenotypes in the Drosophila gut, researchers found that concomitant aneuploidy induction by impairment of the Spindle Assembly Checkpoint consistently led to a more severe progression of intestinal dysplasia or tumorigenesis. 
    [Biology Open]

    Abstract

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    REVIEWS

    DNA Methylation Change Profiling of Colorectal Disease: Screening towards Clinical Use

    Scientists discuss recent progress regarding the identification of unknown hypermethylated genes in colon cancers and IBD, as well as their possible role in clinical practice, which will have important clinical significance, particularly in the era of the personalized medicine.
    [Life]

    Full Article

    INDUSTRY AND POLICY NEWS

    French National Cancer Institute and XBiotech Join forces to Conduct Innovative Phase II/III Adaptive Multicenter Clinical Study for XBiotech’s New Cancer Drug for Colorectal Cancer

    XBiotech announced that it had reached an agreement to supply its new cancer drug XB20-01 to INSERM, and its Federation of Digestive Oncology group.
    [XBiotech (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Microrobots and Nanorobots for Biotechnology

    May 25 – 27, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Fellow – Intestinal Stem Cells & Gastrointestinal Diseases

    Case Western Reserve University – Cleveland, Ohio, United States

    Postdoctoral Research Fellow – mRNA Translation in Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Chair – Gastrointestinal and Pancreatic Cancer Research

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Research Scientist Positions – Gastrointestinal Oncology

    Columbia University Medical Center – New York, New York, United States

    Technical Assistant – Mucosal Immunology

    Research Center for Molecular Medicine – Vienna, Austria

    > See All Jobs

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