Intestinal Cell News Volume 7.19 | May 28 2021

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    2021-05-28 | ICN 7.19


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.19 – 28 May, 2021
    TOP STORY

    Cytosolic Replication in Epithelial Cells Fuels Intestinal Expansion and Chronic Fecal Shedding of Salmonella Typhimurium

    Scientists engineered Salmonella enterica serovar Typhimurium (STm) that self-destructed in the cytosol, but replicated normally in the Salmonella-containing vacuole, to examine the role of cytosolic STm in infection.
    [Cell Host & Microbe]

    AbstractGraphical Abstract

    Scientific resources to support your cancer research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Cyst(e)ine in Nutrition Formulation Promotes Colon Cancer Growth and Chemoresistance by Activating mTORC1 and Scavenging ROS

    Researchers discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival than those who did not.
    [Signal Transduction and Targeted Therapy]

    Full Article

    A Synthetic Probiotic Engineered for Colorectal Cancer Therapy Modulates Gut Microbiota

    Investigators developed an effective bacterial drug delivery system for colorectal cancer therapy using the lactic acid bacterium Pediococcus pentosaceus.
    [Microbiome]

    Full Article

    CBFβ Promotes Colorectal Cancer Progression through Transcriptionally Activating OPN, FAM129A, and UPP1 in a RUNX2-Dependent Manner

    Core-binding factor β (CBFβ) was found to be significantly upregulated in human colorectal cancer (CRC) tissues and correlated with poor survival rate of CRC patients.
    [Cell Death & Differentiation]

    Abstract

    High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

    Using intestinal organoids, scientists showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF Mutant Colorectal Cancer

    Researchers demonstrated that enteroendocrine progenitor cells were enriched in BRAF mutant colorectal cancer patient tumors, cell lines, and patient-derived organoids.
    [Cancer Research]

    Abstract

    Mesenchymal Stem Cell-Derived Microvesicles Improve Intestinal Barrier Function by Restoring Mitochondrial Dynamic Balance in Sepsis Rats

    Cecal ligation and puncture-induced sepsis rats and lipopolysaccharide-stimulated intestinal epithelial cells to investigate the effect of mesenchymal stem cell-derived microvesicles on intestinal barrier dysfunction.
    [Stem Cell Research & Therapy]

    Full Article

    Antrodia salmonea Induces Apoptosis and Enhances Cytoprotective Autophagy in Colon Cancer Cells

    The authors explored the anti-cancer activity of Antrodia salmonea (AS) in colon cancer cells. MTT assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells
    [Aging-Us]

    Full Article

    Total Glucosides of Paeony Restores Intestinal Barrier Function through Inhibiting Lyn/Snail Signaling Pathway in Colitis Mice

    Scientists evaluated the effect and mechanism of Total Glucosides of Paeony on inflammatory bowel disease. DSS-induced colitis mouse model was used. TGP was given by gavage. Caco-2 cells were stimulated by outer membrane vesicles to establish an in vitro model.
    [Phytomedicine]

    AbstractGraphical Abstract

    ADAMTS12 Acts as a Tumor Microenvironment Related Cancer Promoter in Gastric Cancer

    CIBERSORT analysis for the proportion of tumor-infiltrating immune cells revealed that ADAMTS12 expression was positively correlated with Macrophages M0/M1/M2 and negatively correlated with T cells follicular helper.
    [Scientific Reports]

    Full Article

    Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease

    Researchers obtained human ileal samples after fecal stream diversions in patients with rectal cancer or Crohn’s disease. They examined the epithelium and lamina propria cell phenotypes in the defunctioned ileum.
    [Digestive Diseases and Sciences]

    Abstract

    Research Is Challenging. Learning to Culture Cells Shouldn't Be. Attend Training
    REVIEWS

    Implications of Lymphatic Alterations in the Pathogenesis and Treatment of Inflammatory Bowel Disease

    The authors examine the implications of lymphatic changes in IBD pathogenesis related to immune cells, gut microbiota, intestinal and mesenteric epithelial barrier integrity, and progression to colorectal cancer.
    [Biomedicine & Pharmacotherapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    US Food and Drug Administration Approves Bristol Myers Squibb’s Zeposia® (Ozanimod), an Oral Treatment for Adults with Moderately to Severely Active Ulcerative Colitis

    Bristol Myers Squibb announced that the FDA approved Zeposia® 0.92 mg for the treatment of adults with moderately to severely active ulcerative colitis, a chronic inflammatory bowel disease.
    [Bristol Myers Squibb (BusinessWire, Inc)]

    Press Release

    Bristol Myers Squibb Receives Positive CHMP Opinion Recommending Opdivo (Nivolumab) plus Yervoy (Ipilimumab) for Treatment of Mismatch Repair Deficient or Microsatellite Instability–High Metastatic Colorectal Cancer after Prior Chemotherapy

    Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency recommended approval of Opdivo in combination with Yervoy for the treatment of adult patients with mismatch repair deficient or microsatellite instability-high metastatic colorectal cancer after prior fluoropyrimidine-based combination chemotherapy.
    [Bristol Myers Squibb (BusinessWire, Inc)]

    Press Release

    FEATURED EVENT

    Cancer Discovery Symposium

    June 21 – 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Gastrointestinal Pathophysiology

    University of Maryland, College Park – College Park, Maryland, United States

    Postdoctoral Fellow – Gut Metabolites in Organoid Infection Models

    Uppsala University – Uppsala, Sweden

    Postdoctoral Position – Intestinal Epithelial Barrier in Autoimmune Diseases

    BioMed X Institute – Heidelberg, Germany

    Research Fellow – Intestinal Stem Cells & Gastrointestinal Diseases

    Case Western Reserve University – Cleveland, Ohio, United States

    Chair – Gastrointestinal and Pancreatic Cancer Research

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    > See All Jobs

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